ID Q0SJF8_RHOJR Unreviewed; 465 AA.
AC Q0SJF8;
DT 05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 125.
DE SubName: Full=Malate dehydrogenase (Oxaloacetate-decarboxylating) {ECO:0000313|EMBL:ABG92328.1};
DE EC=1.1.1.38 {ECO:0000313|EMBL:ABG92328.1};
GN OrderedLocusNames=RHA1_ro00492 {ECO:0000313|EMBL:ABG92328.1};
OS Rhodococcus jostii (strain RHA1).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=101510 {ECO:0000313|EMBL:ABG92328.1, ECO:0000313|Proteomes:UP000008710};
RN [1] {ECO:0000313|Proteomes:UP000008710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RHA1 {ECO:0000313|Proteomes:UP000008710};
RX PubMed=17030794; DOI=10.1073/pnas.0607048103;
RA McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C.,
RA Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H.,
RA Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H.,
RA Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R.,
RA Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W.,
RA Eltis L.D.;
RT "The complete genome of Rhodococcus sp. RHA1 provides insights into a
RT catabolic powerhouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; CP000431; ABG92328.1; -; Genomic_DNA.
DR RefSeq; WP_011593757.1; NC_008268.1.
DR AlphaFoldDB; Q0SJF8; -.
DR KEGG; rha:RHA1_ro00492; -.
DR PATRIC; fig|101510.16.peg.521; -.
DR eggNOG; COG0281; Bacteria.
DR HOGENOM; CLU_034446_2_1_11; -.
DR OrthoDB; 9805787at2; -.
DR Proteomes; UP000008710; Chromosome.
DR GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0008948; F:oxaloacetate decarboxylase activity; IEA:UniProtKB-EC.
DR CDD; cd05311; NAD_bind_2_malic_enz; 1.
DR Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR045213; Malic_NAD-bd_bact_type.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 1.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:ABG92328.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008710}.
FT DOMAIN 92..225
FT /note="Malic enzyme N-terminal"
FT /evidence="ECO:0000259|SMART:SM01274"
FT DOMAIN 237..458
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
SQ SEQUENCE 465 AA; 48174 MW; B2FDEFB63B61F222 CRC64;
MPSPSPGYSI TVRVHAPVGA GTTSTLAAAI ASVKGAMTAL DVVESHPDHM VIDLTCDASD
VAHADQISTA IAEVPGVIVG KVSDRTFLLH LGGKLEVVPT VPLKHRDDLS RAYTPGVARV
CTAIAEHPED VRRLTIKRNT VAVVTDGSAV LGLGNIGAAA SIPVMEGKAA LFKQFAGVDA
WPVCLDTQDP DAIVEIVRAL APVYGGINLE DISAPRCFEI EARLRDILDI PVFHDDQHGT
AIVVLAALTN ALRVVGKSLD RARIVVSGVG AAGHAVIRLL VAQGATNIIG CGRKGILSPD
DTADEFRTWI AEHTNPEGRT GSLRDALVGA DVFIGVSAPN IVTGDDIAAM ADESIVFALA
NPVPEVDPVA AGEHATVVAT GRSDFPNQIN NVLAFPGVFR GLLDAHAVDI TDEMLIAAAG
AIADRVSPSE LNATYIVPSV FDAGVAPAVA AAVREVAERG PQSEK
//
