ID MUTS_BORAP Reviewed; 862 AA.
AC Q0SM54; G0IRX9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN OrderedLocusNames=BAPKO_0850, BafPKo_0825;
OS Borreliella afzelii (strain PKo) (Borrelia afzelii).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Borreliaceae;
OC Borreliella.
OX NCBI_TaxID=390236;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PKo;
RX PubMed=16914037; DOI=10.1186/1471-2164-7-211;
RA Gloeckner G., Schulte-Spechtel U., Schilhabel M., Felder M., Suehnel J.,
RA Wilske B., Platzer M.;
RT "Comparative genome analysis: selection pressure on the Borrelia vls
RT cassettes is essential for infectivity.";
RL BMC Genomics 7:211-211(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PKo;
RX PubMed=22123755; DOI=10.1128/jb.05951-11;
RA Casjens S.R., Mongodin E.F., Qiu W.G., Dunn J.J., Luft B.J.,
RA Fraser-Liggett C.M., Schutzer S.E.;
RT "Whole-genome sequences of two Borrelia afzelii and two Borrelia garinii
RT Lyme disease agent isolates.";
RL J. Bacteriol. 193:6995-6996(2011).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000395; ABH02074.1; -; Genomic_DNA.
DR EMBL; CP002933; AEL70014.1; -; Genomic_DNA.
DR AlphaFoldDB; Q0SM54; -.
DR SMR; Q0SM54; -.
DR STRING; 29518.BLA32_00235; -.
DR KEGG; baf:BAPKO_0850; -.
DR KEGG; bafz:BafPKo_0825; -.
DR PATRIC; fig|390236.22.peg.786; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_12; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000005216; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..862
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000008047"
FT BINDING 608..615
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 862 AA; 99871 MW; 37FC1B106995EAD0 CRC64;
MEKNVTPMMR QYLDIKKKYK DAIIFFRVGN FYEMFFDDAI EASKLLNLTL TKRENVPMCG
VPYHTSKEYI RKLILFDKKV AICEQAANST SVGPLEREVV EVITPGVIVD EDFLNDDVNN
YLVAISDYKN YYSFSYIDLS TSSLGIMFYE NSFFEKLKRD LEKYSPKEII VSENFYYEYS
EKLNLNRFLI NRVPAWHLDK DVAIKTIKEH FNILGLSSLG FDEEKPYYIS IFLIINHIKN
NLKNLLSNID KIDINNDSLY MFLDDVTQVN LELVKNNNDF SSQYSLYSVL NDCKTAMGKR
LLREFILNPI LNIPEINTRL DHVEFFCKNI SLTMTLREAF VNIWDVERII SRIQMKRYIK
KDFLFIEKSL SVFFLVKKLF DKHNFDYWNF DKFEEDSISK VYFLINSAIS SSSDELIKRG
YDLKLDSLKD LKINANKYID EYLESERLLS KINNLKIRKT NNRGLFFEVT KSNYAQVPPH
FMESQTLNSS KRYKTEKLIS LEANINNAED SVVAFEQEIF DEIASNVVKH NKVLKKVAEF
FAYIDLVVNF GYLAKKNEYK RPILTCSKEI FLEKSRHPVV EHYVKNTEIF TENFVKINKE
KYFCLITGPN MAGKSTYLRQ VALITLMAHI GSFVPASRAV IGITDKIFCR IGASDNLAKG
ESTFLVEMNE TANILRNATE KSLIIMDEVG RGTSTNDGLA IAYSIIEYIL EYIKARSLFA
THFHELSAIN HKAFINLSMK IEKQGNELVF LREVEEKPSL NSYGIYVARI AGLPLRVVDR
ANVILKSLGS RKDSSCLEFL PCISSDTCDR EVLKNDTDVH VKLNEYLELK KFISNIDINN
ITPFQSIELL NQLVLKVISQ SS
//
