ID Q0URA5_PHANO Unreviewed; 322 AA.
AC Q0URA5;
DT 05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 2.
DT 24-JAN-2024, entry version 95.
DE RecName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=SNOG_05709 {ECO:0000313|EMBL:EAT86773.2};
OS Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS blotch fungus) (Parastagonospora nodorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC Parastagonospora.
OX NCBI_TaxID=321614 {ECO:0000313|EMBL:EAT86773.2, ECO:0000313|Proteomes:UP000001055};
RN [1] {ECO:0000313|Proteomes:UP000001055}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173
RC {ECO:0000313|Proteomes:UP000001055};
RX PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA Hane J.K., Lowe R.G., Solomon P.S., Tan K.C., Schoch C.L., Spatafora J.W.,
RA Crous P.W., Kodira C., Birren B.W., Galagan J.E., Torriani S.F.,
RA McDonald B.A., Oliver R.P.;
RT "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT analysis of the wheat pathogen Stagonospora nodorum.";
RL Plant Cell 19:3347-3368(2007).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH445332; EAT86773.2; -; Genomic_DNA.
DR RefSeq; XP_001796105.1; XM_001796053.1.
DR AlphaFoldDB; Q0URA5; -.
DR STRING; 321614.Q0URA5; -.
DR EnsemblFungi; SNOT_05709; SNOT_05709; SNOG_05709.
DR GeneID; 5972982; -.
DR KEGG; pno:SNOG_05709; -.
DR VEuPathDB; FungiDB:JI435_057090; -.
DR eggNOG; KOG0409; Eukaryota.
DR HOGENOM; CLU_035117_6_1_1; -.
DR InParanoid; Q0URA5; -.
DR OrthoDB; 203032at2759; -.
DR Proteomes; UP000001055; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006574; P:valine catabolic process; IBA:GO_Central.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR22981; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR22981:SF81; DEHYDROGENASE, PUTATIVE-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000001055}.
FT DOMAIN 9..177
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 183..307
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 187
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 322 AA; 34728 MW; 5BE2D591FCB3ED03 CRC64;
MASSYSFKKL GFIGLGAMGK PMVSHLANKL PADSRIWVYD VVEKVVDELC AEFPERIIKG
ANAKDVAQQD TIVTMVPEGS HVRSVYLDAE NGVCSTDISN KLIIDCSTID TATSLAVKDH
IAKYFPSASF YDSPVSGGVV GAVKGTIAFF LGCAESDPNL ERLTYLMSLM GKQIIPCGGP
SLGLAAKLSN NYLSGIIAIA CSEAFDMGMR SGLDPRTLAK VYAAGTAQNT ICDKFCPVPH
VYPEAPSSGG WKQGFKVQLM RKDFGLAVDM AKRVGSHNVL GDAGLETYDN AANDPRCRDL
DSRVVYRYLG GEEDWQTKMQ SY
//
