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Database: UniProt
Entry: Q0UYR9_PHANO
LinkDB: Q0UYR9_PHANO
Original site: Q0UYR9_PHANO 
ID   Q0UYR9_PHANO            Unreviewed;       709 AA.
AC   Q0UYR9;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-FEB-2008, sequence version 2.
DT   24-JAN-2024, entry version 72.
DE   RecName: Full=uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00013109};
DE            EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109};
DE   AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing] {ECO:0000256|ARBA:ARBA00032649};
DE   AltName: Full=Uroporphyrinogen-III cosynthase {ECO:0000256|ARBA:ARBA00031702};
GN   ORFNames=SNOG_03095 {ECO:0000313|EMBL:EAT89826.2};
OS   Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS   blotch fungus) (Parastagonospora nodorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC   Parastagonospora.
OX   NCBI_TaxID=321614 {ECO:0000313|EMBL:EAT89826.2, ECO:0000313|Proteomes:UP000001055};
RN   [1] {ECO:0000313|Proteomes:UP000001055}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173
RC   {ECO:0000313|Proteomes:UP000001055};
RX   PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA   Hane J.K., Lowe R.G., Solomon P.S., Tan K.C., Schoch C.L., Spatafora J.W.,
RA   Crous P.W., Kodira C., Birren B.W., Galagan J.E., Torriani S.F.,
RA   McDonald B.A., Oliver R.P.;
RT   "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT   analysis of the wheat pathogen Stagonospora nodorum.";
RL   Plant Cell 19:3347-3368(2007).
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC       {ECO:0000256|ARBA:ARBA00004772}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC       {ECO:0000256|ARBA:ARBA00008133}.
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DR   EMBL; CH445328; EAT89826.2; -; Genomic_DNA.
DR   RefSeq; XP_001793680.1; XM_001793628.1.
DR   AlphaFoldDB; Q0UYR9; -.
DR   STRING; 321614.Q0UYR9; -.
DR   EnsemblFungi; SNOT_03095; SNOT_03095; SNOG_03095.
DR   GeneID; 5970537; -.
DR   KEGG; pno:SNOG_03095; -.
DR   VEuPathDB; FungiDB:JI435_030950; -.
DR   eggNOG; KOG4132; Eukaryota.
DR   HOGENOM; CLU_405526_0_0_1; -.
DR   InParanoid; Q0UYR9; -.
DR   OrthoDB; 5481306at2759; -.
DR   UniPathway; UPA00251; UER00320.
DR   Proteomes; UP000001055; Unassembled WGS sequence.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IBA:GO_Central.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IBA:GO_Central.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR12390; UROPORPHYRINOGEN III SYNTHASE; 1.
DR   PANTHER; PTHR12390:SF0; UROPORPHYRINOGEN-III SYNTHASE; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001055}.
FT   DOMAIN          28..296
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
FT   REGION          284..436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          652..678
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        316..341
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..415
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        653..678
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   709 AA;  78748 MW;  2C2C1423EE0E317F CRC64;
     MAEQSRGKIP ILLLKTKSAP RDTYEELFRN LDDHRYTPVF VPVLEHRFRR DALDEVRKHV
     TGRGFVPKAK GGLATYGALI FTSQRAVEAF ADIVEELRKA GNHVDDLLPD SLPLYVVGPA
     TARGLRSLDL KCPILGDETG NGEALATYML EHYNNLYPGA GKPSLLFLVG DKRRDIIPKT
     LQAEELGDER RCRVDELVIY ETGEMQSFKE EFSTLWRKNA DAGCERQWVV VFSPTGCKAM
     LESLDLLDKQ TGRAKSSARN GLNIATIGPT TRDYLQHEFG FQPDVCAERP SPEGIADGTR
     SSPRNAGSSP AKNDDAVAGS KRKPEAEPSP NRGRKASKKQ ATLEETGITN EDSEMKDATN
     GGDAKESEAE TKDDAPKAQE DEENTSDEKD VSDGTAKVET TKDDVKAEAN DDAAKPDAAN
     GEGAVEQSSQ REKEVPSNIL EKGLIYFFTR NRVGIDDAES VGDLQRTFFV LRPLPTGAKL
     GEGAIPDLKN NRLFALPKKT FPKSHTDRFM AFVEKANTTI QDLKDNFFKG SEYETKTQGT
     RQVDPVTPVA EGVYAITRTE DRTTHLVYST TIPSDLGEVQ EDLGIKDQGS FIISVKNPER
     SGPASAQLAQ KPDFSKEIIE EFRGLAWSEV KPKYIDHEYC QILLIGEQLD SGVEPTTKDK
     KHDKETPQEE LEKLEHEDEL RVEHLHGDDS IFDDLKISKK DYPKVPTTW
//
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