ID Q0UYR9_PHANO Unreviewed; 709 AA.
AC Q0UYR9;
DT 05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 2.
DT 24-JAN-2024, entry version 72.
DE RecName: Full=uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00013109};
DE EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109};
DE AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing] {ECO:0000256|ARBA:ARBA00032649};
DE AltName: Full=Uroporphyrinogen-III cosynthase {ECO:0000256|ARBA:ARBA00031702};
GN ORFNames=SNOG_03095 {ECO:0000313|EMBL:EAT89826.2};
OS Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS blotch fungus) (Parastagonospora nodorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC Parastagonospora.
OX NCBI_TaxID=321614 {ECO:0000313|EMBL:EAT89826.2, ECO:0000313|Proteomes:UP000001055};
RN [1] {ECO:0000313|Proteomes:UP000001055}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173
RC {ECO:0000313|Proteomes:UP000001055};
RX PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA Hane J.K., Lowe R.G., Solomon P.S., Tan K.C., Schoch C.L., Spatafora J.W.,
RA Crous P.W., Kodira C., Birren B.W., Galagan J.E., Torriani S.F.,
RA McDonald B.A., Oliver R.P.;
RT "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT analysis of the wheat pathogen Stagonospora nodorum.";
RL Plant Cell 19:3347-3368(2007).
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC {ECO:0000256|ARBA:ARBA00004772}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC {ECO:0000256|ARBA:ARBA00008133}.
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DR EMBL; CH445328; EAT89826.2; -; Genomic_DNA.
DR RefSeq; XP_001793680.1; XM_001793628.1.
DR AlphaFoldDB; Q0UYR9; -.
DR STRING; 321614.Q0UYR9; -.
DR EnsemblFungi; SNOT_03095; SNOT_03095; SNOG_03095.
DR GeneID; 5970537; -.
DR KEGG; pno:SNOG_03095; -.
DR VEuPathDB; FungiDB:JI435_030950; -.
DR eggNOG; KOG4132; Eukaryota.
DR HOGENOM; CLU_405526_0_0_1; -.
DR InParanoid; Q0UYR9; -.
DR OrthoDB; 5481306at2759; -.
DR UniPathway; UPA00251; UER00320.
DR Proteomes; UP000001055; Unassembled WGS sequence.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IBA:GO_Central.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IBA:GO_Central.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR12390; UROPORPHYRINOGEN III SYNTHASE; 1.
DR PANTHER; PTHR12390:SF0; UROPORPHYRINOGEN-III SYNTHASE; 1.
DR Pfam; PF02602; HEM4; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001055}.
FT DOMAIN 28..296
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
FT REGION 284..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..341
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..415
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 709 AA; 78748 MW; 2C2C1423EE0E317F CRC64;
MAEQSRGKIP ILLLKTKSAP RDTYEELFRN LDDHRYTPVF VPVLEHRFRR DALDEVRKHV
TGRGFVPKAK GGLATYGALI FTSQRAVEAF ADIVEELRKA GNHVDDLLPD SLPLYVVGPA
TARGLRSLDL KCPILGDETG NGEALATYML EHYNNLYPGA GKPSLLFLVG DKRRDIIPKT
LQAEELGDER RCRVDELVIY ETGEMQSFKE EFSTLWRKNA DAGCERQWVV VFSPTGCKAM
LESLDLLDKQ TGRAKSSARN GLNIATIGPT TRDYLQHEFG FQPDVCAERP SPEGIADGTR
SSPRNAGSSP AKNDDAVAGS KRKPEAEPSP NRGRKASKKQ ATLEETGITN EDSEMKDATN
GGDAKESEAE TKDDAPKAQE DEENTSDEKD VSDGTAKVET TKDDVKAEAN DDAAKPDAAN
GEGAVEQSSQ REKEVPSNIL EKGLIYFFTR NRVGIDDAES VGDLQRTFFV LRPLPTGAKL
GEGAIPDLKN NRLFALPKKT FPKSHTDRFM AFVEKANTTI QDLKDNFFKG SEYETKTQGT
RQVDPVTPVA EGVYAITRTE DRTTHLVYST TIPSDLGEVQ EDLGIKDQGS FIISVKNPER
SGPASAQLAQ KPDFSKEIIE EFRGLAWSEV KPKYIDHEYC QILLIGEQLD SGVEPTTKDK
KHDKETPQEE LEKLEHEDEL RVEHLHGDDS IFDDLKISKK DYPKVPTTW
//