ID Q0V986_XENTR Unreviewed; 448 AA.
AC Q0V986; F6V546;
DT 05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE SubName: Full=DMRT-like family A1 {ECO:0000313|EMBL:AAI21705.1, ECO:0000313|Ensembl:ENSXETP00000012020};
DE SubName: Full=Dmrt4 {ECO:0000313|EMBL:AEM44778.1};
DE SubName: Full=Doublesex- and mab-3-related transcription factor A1 {ECO:0000313|RefSeq:NP_001072447.1};
GN Name=dmrta1 {ECO:0000313|Ensembl:ENSXETP00000012020,
GN ECO:0000313|RefSeq:NP_001072447.1,
GN ECO:0000313|Xenbase:XB-GENE-984361};
GN Synonyms=dmo {ECO:0000313|RefSeq:NP_001072447.1}, dmrt4
GN {ECO:0000313|RefSeq:NP_001072447.1}, dmrt99b
GN {ECO:0000313|EMBL:AAI21705.1, ECO:0000313|RefSeq:NP_001072447.1},
GN XDmrt4 {ECO:0000313|RefSeq:NP_001072447.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI21705.1};
RN [1] {ECO:0000313|RefSeq:NP_001072447.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI21705.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=N6 {ECO:0000313|EMBL:AAI21705.1};
RC TISSUE=Oviduct {ECO:0000313|EMBL:AAI21705.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000012020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000012020};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|EMBL:AEM44778.1}
RP NUCLEOTIDE SEQUENCE.
RA Huang X., Zhu X.;
RT "Dmrt5 plays important roles during Xenopus tropicalis olfactory
RT neurogenesis.";
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Ensembl:ENSXETP00000012020}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [6] {ECO:0000313|RefSeq:NP_001072447.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00070}.
CC -!- SIMILARITY: Belongs to the DMRT family.
CC {ECO:0000256|ARBA:ARBA00006834}.
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DR EMBL; BC121704; AAI21705.1; -; mRNA.
DR EMBL; HQ171198; AEM44778.1; -; mRNA.
DR RefSeq; NP_001072447.1; NM_001078979.1.
DR STRING; 8364.ENSXETP00000015595; -.
DR PaxDb; 8364-ENSXETP00000012020; -.
DR PaxDb; 8364-ENSXETP00000027196; -.
DR DNASU; 779901; -.
DR Ensembl; ENSXETT00000012020; ENSXETP00000012020; ENSXETG00000005462.
DR GeneID; 779901; -.
DR KEGG; xtr:779901; -.
DR AGR; Xenbase:XB-GENE-984361; -.
DR CTD; 63951; -.
DR Xenbase; XB-GENE-984361; dmrta1.
DR eggNOG; KOG3815; Eukaryota.
DR HOGENOM; CLU_038477_1_0_1; -.
DR OMA; ELQFMYT; -.
DR OrthoDB; 5401440at2759; -.
DR TreeFam; TF317837; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Bgee; ENSXETG00000005462; Expressed in neurula embryo and 1 other cell type or tissue.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd14417; CUE_DMA_DMRTA1; 1.
DR Gene3D; 4.10.1040.10; DM DNA-binding domain; 1.
DR InterPro; IPR001275; DM_DNA-bd.
DR InterPro; IPR036407; DM_DNA-bd_sf.
DR InterPro; IPR005173; DMA.
DR InterPro; IPR026607; DMRT.
DR InterPro; IPR046472; DMRT5_1_DMB_dom.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR12322; DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT; 1.
DR PANTHER; PTHR12322:SF71; DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR A1; 1.
DR Pfam; PF00751; DM; 1.
DR Pfam; PF03474; DMA; 1.
DR Pfam; PF20624; DMRT5_DMB; 1.
DR SMART; SM00301; DM; 1.
DR SUPFAM; SSF82927; Cysteine-rich DNA binding domain, (DM domain); 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS40000; DM_1; 1.
DR PROSITE; PS50809; DM_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00070};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00070};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00070}; Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00070}.
FT DOMAIN 83..130
FT /note="DM"
FT /evidence="ECO:0000259|PROSITE:PS50809"
FT DNA_BIND 83..130
FT /note="DM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00070"
FT REGION 165..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 448 AA; 49140 MW; 99FA686187AB779F CRC64;
MDCKSPNINP RPLLHPGLLS STPSLPSSSV LSMPPNVPMP ASFLRPPTLL LRAAAANATC
SPRVTVSLDR GSGNALYPRT PKCARCRNHG VVSALKGHKR FCRWRDCSCA KCTLIAERQR
VMAAQVALRR QQAQEECEVR DVQHFLYPGG ERETPGTRAQ TLQIISREEN KDETSEKTEQ
TYERIPTSSI FSHSLPQPSP SGIVNACHIL KSAGPENSNK DECIQSSGSE ERSEGADSPR
SLSSCDLESG NECEWPKDLS ASSSKIPVVP SRQRDPLEIL RKVFPNQKQS SLQSILQYCK
GDVVQAIEFV LNGKEDKKDA KDTESSLGPD RNAFTKESAL NLTGLGIGGF GTKSAFSPLH
TNQSCVGSDS NIFSSRLGFT PLRLAYSTSN RIPGFISPYL TSGLVPPFPF RPGLDYSFPG
MLRDPSYYQH KDNVNLTGLY SRLNHENQ
//
