ID Q0VCC9_BOVIN Unreviewed; 209 AA.
AC Q0VCC9; F1MXT7;
DT 05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE SubName: Full=MAD4 {ECO:0000313|EMBL:ABQ13040.1};
DE SubName: Full=MAX dimerization protein 4 {ECO:0000313|EMBL:AAI20231.1, ECO:0000313|Ensembl:ENSBTAP00000020233.4};
GN Name=MXD4 {ECO:0000313|EMBL:AAI20231.1,
GN ECO:0000313|Ensembl:ENSBTAP00000020233.4,
GN ECO:0000313|VGNC:VGNC:31772};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI20231.1};
RN [1] {ECO:0000313|EMBL:ABQ13040.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2] {ECO:0000313|EMBL:AAI20231.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hereford {ECO:0000313|EMBL:AAI20231.1};
RC TISSUE=Fetal medulla {ECO:0000313|EMBL:AAI20231.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ABQ13040.1}
RP NUCLEOTIDE SEQUENCE.
RA Song W.-J., Kurnit D.M.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSBTAP00000020233.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000020233.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Ensembl:ENSBTAP00000020233.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000020233.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; BC120230; AAI20231.1; -; mRNA.
DR EMBL; BT030600; ABQ13040.1; -; mRNA.
DR RefSeq; NP_001069724.1; NM_001076256.1.
DR PaxDb; 9913-ENSBTAP00000020233; -.
DR Ensembl; ENSBTAT00000020233.5; ENSBTAP00000020233.4; ENSBTAG00000015209.5.
DR GeneID; 541116; -.
DR KEGG; bta:541116; -.
DR CTD; 10608; -.
DR VEuPathDB; HostDB:ENSBTAG00000015209; -.
DR VGNC; VGNC:31772; MXD4.
DR eggNOG; KOG2483; Eukaryota.
DR GeneTree; ENSGT00940000160120; -.
DR HOGENOM; CLU_082604_2_0_1; -.
DR OrthoDB; 5402993at2759; -.
DR TreeFam; TF315654; -.
DR Proteomes; UP000009136; Chromosome 6.
DR Bgee; ENSBTAG00000015209; Expressed in neutrophil and 107 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd18929; bHLHzip_Mad4; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR11969:SF4; MAX DIMERIZATION PROTEIN 4; 1.
DR PANTHER; PTHR11969; MAX DIMERIZATION, MAD; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 53..105
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 138..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 102..136
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 138..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 209 AA; 23539 MW; 9A461B03DA984235 CRC64;
MELNSLLILL EAAEYLERRD REAEHGYASV LPFDGDFARK KTKAAGLVRK APNNRSSHNE
LEKHRRAKLR LYLEQLKQLV PLGPDSTRHT TLSLLKRAKM HIKKLEEQDR RALSIKEQLQ
REHRFLKRRL EQLSAQSLER VRTDSTGSAV STDDSEQEVD VEGMEFGPGE LDSVGSGSDV
DDHYSLRGGG CSHGSFGPPC RRPGRPGLS
//
