ID ANKY2_BOVIN Reviewed; 442 AA.
AC Q0VCS9;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 24-JAN-2024, entry version 91.
DE RecName: Full=Ankyrin repeat and MYND domain-containing protein 2;
GN Name=ANKMY2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in the trafficking of signaling proteins to
CC the cilia. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the retinal-specific guanylyl cyclase GC1.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
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DR EMBL; BC120022; AAI20023.1; -; mRNA.
DR RefSeq; NP_001068852.1; NM_001075384.2.
DR RefSeq; XP_005205233.1; XM_005205176.3.
DR AlphaFoldDB; Q0VCS9; -.
DR SMR; Q0VCS9; -.
DR STRING; 9913.ENSBTAP00000014576; -.
DR PaxDb; 9913-ENSBTAP00000014576; -.
DR Ensembl; ENSBTAT00000014576.6; ENSBTAP00000014576.5; ENSBTAG00000010980.6.
DR GeneID; 509032; -.
DR KEGG; bta:509032; -.
DR CTD; 57037; -.
DR VEuPathDB; HostDB:ENSBTAG00000010980; -.
DR VGNC; VGNC:25906; ANKMY2.
DR eggNOG; KOG1710; Eukaryota.
DR GeneTree; ENSGT00390000016820; -.
DR HOGENOM; CLU_048951_0_0_1; -.
DR InParanoid; Q0VCS9; -.
DR OMA; NNYVTRS; -.
DR OrthoDB; 2882203at2759; -.
DR TreeFam; TF351374; -.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000010980; Expressed in prostate gland and 106 other cell types or tissues.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR24150; ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR24150:SF8; ANKYRIN REPEAT AND MYND DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; Cell projection; Cilium; Metal-binding; Reference proteome;
KW Repeat; Zinc; Zinc-finger.
FT CHAIN 1..442
FT /note="Ankyrin repeat and MYND domain-containing protein 2"
FT /id="PRO_0000263083"
FT REPEAT 45..74
FT /note="ANK 1"
FT REPEAT 79..108
FT /note="ANK 2"
FT REPEAT 159..188
FT /note="ANK 3"
FT ZN_FING 320..357
FT /note="MYND-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT REGION 401..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 320
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 323
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 332
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 335
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 341
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 345
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 353
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 357
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
SQ SEQUENCE 442 AA; 49408 MW; F4F35CD99A55A967 CRC64;
MVHIKKGELT QEEKELLEVI GKGTVQEAGT LLGSKNVRVN CLDENGMTPL MHAAYKGKLD
MCKLLLRHGA DVNCHQHEHG YTALMFAALS GNKDITWVML EAGAETDVVN SVGRTAAQMA
AFVGQHDCVT IINNFFPREK LDYYTKPQGL DKEPKLPPKL AGPLHKIITT TNLHPVKIVM
LINENPLLAE EAALNKCYKV MDLICEKCMK QRDMNEVLAM KMHYISCIFQ KCINFLKDRE
NKLDTLIKSL LKGRASDGFP VYQEKIIRES IRKFPYCEAT LLQQLVRSIA PVEIGSDPTA
FSVLTQAITG QVGFVDVEFC TTCGEKGASK RCSVCKMVIY CDQTCQKTHW FAHKKICKNL
KDIYEKQQLE AAKAKSEEEN NSKLDVNSNC VGEERLEEAE TRICQKNDNP KDSEEGEKES
LQSDAGLEGL QEAAVGPQVS EE
//
