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Database: UniProt
Entry: Q0VD28_BOVIN
LinkDB: Q0VD28_BOVIN
Original site: Q0VD28_BOVIN 
ID   Q0VD28_BOVIN            Unreviewed;       420 AA.
AC   Q0VD28;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   16-OCT-2019, entry version 111.
DE   SubName: Full=Potassium inwardly-rectifying channel, subfamily J, member 16 {ECO:0000313|EMBL:AAI19869.1};
DE   SubName: Full=Potassium voltage-gated channel subfamily J member 16 {ECO:0000313|Ensembl:ENSBTAP00000034572};
GN   Name=KCNJ16 {ECO:0000313|EMBL:AAI19869.1,
GN   ECO:0000313|Ensembl:ENSBTAP00000034572, ECO:0000313|VGNC:VGNC:30459};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI19869.1};
RN   [1] {ECO:0000313|EMBL:AAI19869.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=L1 Hereford {ECO:0000313|EMBL:AAI19869.1};
RC   TISSUE=Thalamus {ECO:0000313|EMBL:AAI19869.1};
RA   Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA   Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA   Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA   Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA   Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D.,
RA   Siddiqui A., Holt R., Jones S.J., Marra M.A.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000034572, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000034572,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [3] {ECO:0000313|Ensembl:ENSBTAP00000034572}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000034572};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; BC119868; AAI19869.1; -; mRNA.
DR   RefSeq; NP_001069762.1; NM_001076294.1.
DR   RefSeq; XP_005221400.1; XM_005221343.3.
DR   RefSeq; XP_005221401.1; XM_005221344.3.
DR   RefSeq; XP_010814951.1; XM_010816649.2.
DR   RefSeq; XP_010814952.1; XM_010816650.2.
DR   RefSeq; XP_015314503.1; XM_015459017.1.
DR   RefSeq; XP_015314504.1; XM_015459018.1.
DR   RefSeq; XP_015314505.1; XM_015459019.1.
DR   SMR; Q0VD28; -.
DR   STRING; 9913.ENSBTAP00000034572; -.
DR   Ensembl; ENSBTAT00000034686; ENSBTAP00000034572; ENSBTAG00000024903.
DR   GeneID; 613890; -.
DR   KEGG; bta:613890; -.
DR   CTD; 3773; -.
DR   VGNC; VGNC:30459; KCNJ16.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00970000193347; -.
DR   HOGENOM; HOG000237325; -.
DR   KO; K05009; -.
DR   OMA; SSYPIVN; -.
DR   OrthoDB; 956263at2759; -.
DR   TreeFam; TF313676; -.
DR   Reactome; R-BTA-1296041; Activation of G protein gated Potassium channels.
DR   Reactome; R-BTA-1296067; Potassium transport channels.
DR   Reactome; R-BTA-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000024903; Expressed in 6 organ(s), highest expression level in adult mammalian kidney.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR008061; K_chnl_inward-rec_Kir5.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF24; PTHR11767:SF24; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01678; KIR5CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     74     96       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    146    171       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       38    175       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      183    349       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      382    401       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        162    162       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   420 AA;  47729 MW;  C861F9C7556C6D84 CRC64;
     MSHYCSSYPI VSVDPKCPGY APEHLLAEKR RARRRLLHKD GSCNVYFKHI FGEWGSYVVD
     IFTTLVDTKW RHMFVIFSLS YILSWLTFGS VFWLIAFHHG DLQNDGPDAT PCVDNVHSFT
     GAFLFSLETQ TTIGYGYRCV TEECPVAVLT VILQSILSCV INTFIIGAAL AKMATARKRA
     QTIRFSYFAL VGMRDGKLCL MWRIGDFRPN HVVEGTVRAQ LLRYAEDGEG RMTMAFKDLR
     LLNDQIILVT PVTVVHEIDR DSPLYALDRK AVARDNFEIL VTFIYTGDST GTSHQSRSSY
     IPREILWGHR FHDVLEVKRK YYKVNCLQFE GSVEVYAPFC SAKQLDWKDQ QLHSVERAPP
     VRASAPPDAK VRRRSFSAVA IVSSSENPEE TTPSAPEECK EAPYQKALLT LNRISVESQM
//
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