ID   CF157_XENTR             Reviewed;         519 AA.
AC   Q0VFN8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=Cilia- and flagella-associated protein 157 {ECO:0000305};
GN   Name=cfap157 {ECO:0000250|UniProtKB:Q5JU67};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specifically required during spermatogenesis for flagellum
CC       morphogenesis and sperm motility. {ECO:0000250|UniProtKB:Q0VFX2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250|UniProtKB:Q0VFX2}.
CC   -!- SIMILARITY: Belongs to the CFAP157 family. {ECO:0000305}.
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DR   EMBL; BC118759; AAI18760.1; -; mRNA.
DR   RefSeq; NP_001072774.1; NM_001079306.1.
DR   AlphaFoldDB; Q0VFN8; -.
DR   SMR; Q0VFN8; -.
DR   PaxDb; 8364-ENSXETP00000009700; -.
DR   DNASU; 780234; -.
DR   GeneID; 780234; -.
DR   KEGG; xtr:780234; -.
DR   AGR; Xenbase:XB-GENE-5795998; -.
DR   CTD; 286207; -.
DR   Xenbase; XB-GENE-5795998; cfap157.
DR   eggNOG; ENOG502QQK8; Eukaryota.
DR   InParanoid; Q0VFN8; -.
DR   OrthoDB; 5404426at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR   GO; GO:0007288; P:sperm axoneme assembly; ISS:UniProtKB.
DR   InterPro; IPR038844; CFAP157.
DR   PANTHER; PTHR31954; CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157; 1.
DR   PANTHER; PTHR31954:SF1; CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 157; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..519
FT                   /note="Cilia- and flagella-associated protein 157"
FT                   /id="PRO_0000307229"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          28..185
FT                   /evidence="ECO:0000255"
FT   COILED          241..356
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   519 AA;  59576 MW;  92B7D30ABD5D5D0F CRC64;
     MPPKKKGKRG PSAKTKEKET VRVASEGVTE QTKDFYTVQI RDLEKRLERY QSKWDEICAK
     EQLKEAQYEQ LSNDKKEIVS FLKRTLNQRM DEIADLNDQL LGLQQAKDAE KDAYESQLTQ
     VRHELQDTKE RLTSENMLLA GKLASLEEFR VQKEELMGKF AALEEKVKEQ EQEHKEAMYI
     LEKKVVLDKD RLKKEMVQRV STVAAEFRRV SNNQMAETTK RAIRENVSIS LQLDKMSDKS
     IELISENDLL KDRNSELTKQ LEMLEENEKE LVKNNLSNQK VIRMLTDKCQ QQQEILTLLE
     HTQHALNELQ SQHHNLKDES QQLKQKLVSL EDDLQRVTQE KEGLSRQLEE EKQRTLAVDM
     ILSQAAAFLK DMLLTHSEDE TEGMQLERRN KMLQQLQLLL DSSATLGLGS SLHEFETKQG
     HSLKSLKTNR QPVSPVLKGP GVTAHYRIGD LGLVPRQDVS NAVLSKTAML SKITRLGPLR
     GTHGISKELL SWTQEEKQIK HSALPEISPG APSKLLMAK
//