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Database: UniProt
Entry: Q0VFR6_XENTR
LinkDB: Q0VFR6_XENTR
Original site: Q0VFR6_XENTR 
ID   Q0VFR6_XENTR            Unreviewed;       288 AA.
AC   Q0VFR6;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   24-JAN-2024, entry version 119.
DE   RecName: Full=Syntaxin-1A {ECO:0000256|ARBA:ARBA00040530};
GN   Name=stx1a {ECO:0000313|EMBL:AAI18730.1,
GN   ECO:0000313|Ensembl:ENSXETP00000059342,
GN   ECO:0000313|RefSeq:NP_001072191.1,
GN   ECO:0000313|Xenbase:XB-GENE-976753};
GN   Synonyms=hpc-1 {ECO:0000313|RefSeq:NP_001072191.1}, p35-1
GN   {ECO:0000313|RefSeq:NP_001072191.1}, stx1
GN   {ECO:0000313|RefSeq:NP_001072191.1}, sx1a
GN   {ECO:0000313|RefSeq:NP_001072191.1}, syntaxin1a
GN   {ECO:0000313|RefSeq:NP_001072191.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI18730.1};
RN   [1] {ECO:0000313|RefSeq:NP_001072191.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12454917; DOI=10.1002/dvdy.10174;
RA   Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA   Richardson P.;
RT   "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT   initiative.";
RL   Dev. Dyn. 225:384-391(2002).
RN   [2] {ECO:0000313|EMBL:AAI18730.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAI18730.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|RefSeq:NP_001072191.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=19331362;
RA   Feinshreiber L., Chikvashvili D., Michaelevski I., Lotan I.;
RT   "Syntaxin modulates Kv1.1 through dual action on channel surface expression
RT   and conductance.";
RL   Biochemistry 48:4109-4114(2009).
RN   [4] {ECO:0000313|Ensembl:ENSXETP00000059342}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000059342};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [5] {ECO:0000313|Ensembl:ENSXETP00000059342}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2020) to UniProtKB.
RN   [6] {ECO:0000313|RefSeq:NP_001072191.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
CC       {ECO:0000256|ARBA:ARBA00004143}; Single-pass type IV membrane protein
CC       {ECO:0000256|ARBA:ARBA00004143}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the syntaxin family.
CC       {ECO:0000256|ARBA:ARBA00009063, ECO:0000256|RuleBase:RU003858}.
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DR   EMBL; BC118729; AAI18730.1; -; mRNA.
DR   RefSeq; NP_001072191.1; NM_001078723.1.
DR   PaxDb; 8364-ENSXETP00000059342; -.
DR   DNASU; 779637; -.
DR   Ensembl; ENSXETT00000066319; ENSXETP00000059342; ENSXETG00000010345.
DR   GeneID; 779637; -.
DR   KEGG; xtr:779637; -.
DR   CTD; 6804; -.
DR   Xenbase; XB-GENE-976753; stx1a.
DR   eggNOG; KOG0810; Eukaryota.
DR   HOGENOM; CLU_042423_2_2_1; -.
DR   OMA; RWICFIL; -.
DR   OrthoDB; 2876074at2759; -.
DR   TreeFam; TF313763; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Bgee; ENSXETG00000010345; Expressed in brain and 14 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005484; F:SNAP receptor activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   CDD; cd15880; SNARE_syntaxin1; 1.
DR   CDD; cd00179; SynN; 1.
DR   Gene3D; 1.20.5.110; -; 1.
DR   Gene3D; 1.20.58.70; -; 1.
DR   InterPro; IPR010989; SNARE.
DR   InterPro; IPR045242; Syntaxin.
DR   InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR   InterPro; IPR006011; Syntaxin_N.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   PANTHER; PTHR19957; SYNTAXIN; 1.
DR   PANTHER; PTHR19957:SF84; SYNTAXIN-1A; 1.
DR   Pfam; PF05739; SNARE; 1.
DR   Pfam; PF00804; Syntaxin; 1.
DR   SMART; SM00503; SynN; 1.
DR   SMART; SM00397; t_SNARE; 1.
DR   SUPFAM; SSF47661; t-snare proteins; 1.
DR   PROSITE; PS00914; SYNTAXIN; 1.
DR   PROSITE; PS50192; T_SNARE; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   TRANSMEM        266..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          192..254
FT                   /note="T-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000259|PROSITE:PS50192"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          68..106
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   288 AA;  33144 MW;  F0FFAAEF0B9E2067 CRC64;
     MKDRTRELRA AKDSDEDDEV TVSLDRDRFM DEFFEQVEEI RGFIDKIAEN VEEVKRKHSA
     ILASPNPDEK TKAELEELMS DIKKTANKVR SKLKGIEQSI EQEEAMNRSS ADLRIRKTQH
     STLSRKFVEV MSEYNATQSD YRERCKGRIQ RQLEITGRTT TSEELEDMLE SGNPAIFSSG
     IIMDSNITKQ ALNEIETRHS EIIKLENSIR ELHDMFMDMA MLVESQGEMI DRIEYNVEHS
     VDYVERAVSD TKKAVKYQSK ARRKKIMIII CCVVLGIVIA STFGGIFG
//
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