ID   Q0W1G8_METAR            Unreviewed;       770 AA.
AC   Q0W1G8;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   27-MAR-2024, entry version 96.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   Name=polB-3 {ECO:0000313|EMBL:CAJ37775.1};
GN   ORFNames=RCIX2734 {ECO:0000313|EMBL:CAJ37775.1};
OS   Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=351160 {ECO:0000313|EMBL:CAJ37775.1, ECO:0000313|Proteomes:UP000000663};
RN   [1] {ECO:0000313|EMBL:CAJ37775.1, ECO:0000313|Proteomes:UP000000663}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22066 / NBRC 105507 / MRE50
RC   {ECO:0000313|Proteomes:UP000000663};
RX   PubMed=16857943; DOI=10.1126/science.1127062;
RA   Erkel C., Kube M., Reinhardt R., Liesack W.;
RT   "Genome of rice cluster I archaea -- the key methane producers in the rice
RT   rhizosphere.";
RL   Science 313:370-372(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632,
CC         ECO:0000256|RuleBase:RU000442};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM114193; CAJ37775.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0W1G8; -.
DR   STRING; 351160.RCIX2734; -.
DR   KEGG; rci:RCIX2734; -.
DR   PATRIC; fig|351160.9.peg.510; -.
DR   eggNOG; arCOG00329; Archaea.
DR   Proteomes; UP000000663; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd05531; POLBc_B2; 1.
DR   Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR   Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR   Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR   PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000663};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN          374..725
FT                   /note="DNA-directed DNA polymerase family B
FT                   multifunctional"
FT                   /evidence="ECO:0000259|Pfam:PF00136"
SQ   SEQUENCE   770 AA;  87033 MW;  33B60F0FB7BD0798 CRC64;
     MIVDLWHRPS TDSQHGAYLL WLRTADGIIC VEDREFRPSF SVIPSTQARL VEQVVAQHEN
     VARAETACRY PSIYAADQVP VIRAFMLDER RAEETMREIR ARAPAEVRFA EWKLLPELQW
     YYLRRIPPHS LVAIEAEGGV LQSIEYIGPA DSEALKVMAI YPAFTTRVPA NCRIQSITLR
     YGKEEVAISG REEDVLAEMQ RRLDACDPDA IAIFDADWET LPLLGLRAQD NNMRLRLGRL
     PDPTKLYPPR GAVRHWQAKQ VRTPGRILLD LWKDARTDAD LKRTGLDLDD VYGAEFHDRQ
     KSPASMVYDL ARERLPMLMS WCHRCLMPLD SVCREKHGFM NASSVNSTLI ESTVIPDEPE
     YPEGFKTPLT EQLKENGGLV ITPEAGLHEN VAIVDFSSLF PRIFVKHNIS PETINCRHPE
     CRAHGERVPF LDFHICRKRK GVYPVVFGKV LAERDAVKAK LKSLDPASEE YRKLEMLYKS
     LKMQLVSPYG YMQFALNNFR SVDGNRSIPA YGRHYLLRAR DIAEDAGFNV IYADTDSLFI
     QGGDRELYTA FCNRISADFG LELKLEHVCR WVLFLPEHPG GKKGLKKKYF ASVDGEVLVR
     GLEVRRQDRA AITKKVQEHV LEILASANDA TEFRAMIPKV AAYVRGEVAR IQAGNVTPEE
     LAIVRKLSHR PEEYKALPHH AVAAEALAAK GRSVRVGGKV EYIVTGTNKA TPLALAGNDP
     EYDVASYVEN TVHPIYMLLR EFGLKYEDLL PGPKQVGLDA FMGADSICQV
//