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Database: UniProt
Entry: Q0W339_METAR
LinkDB: Q0W339_METAR
Original site: Q0W339_METAR 
ID   Q0W339_METAR            Unreviewed;       556 AA.
AC   Q0W339;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   28-FEB-2018, entry version 68.
DE   RecName: Full=Methyl-coenzyme M reductase subunit alpha {ECO:0000256|PIRNR:PIRNR000262};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000262};
GN   Name=mcrA {ECO:0000313|EMBL:CAJ37204.1};
GN   ORFNames=RCIX2063 {ECO:0000313|EMBL:CAJ37204.1};
OS   Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanocellales;
OC   Methanocellaceae; Methanocella.
OX   NCBI_TaxID=351160 {ECO:0000313|EMBL:CAJ37204.1, ECO:0000313|Proteomes:UP000000663};
RN   [1] {ECO:0000313|EMBL:CAJ37204.1, ECO:0000313|Proteomes:UP000000663}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22066 / NBRC 105507 / MRE50
RC   {ECO:0000313|Proteomes:UP000000663};
RX   PubMed=16857943; DOI=10.1126/science.1127062;
RA   Erkel C., Kube M., Reinhardt R., Liesack W.;
RT   "Genome of rice cluster I archaea -- the key methane producers in the
RT   rice rhizosphere.";
RL   Science 313:370-372(2006).
CC   -!- FUNCTION: Reduction of methyl-coenzyme M (2-(methylthio)
CC       ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate
CC       to methane and a heterodisulfide. {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CATALYTIC ACTIVITY: Methyl-CoM + CoB = CoM-S-S-CoB + methane.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- COFACTOR:
CC       Name=coenzyme F430; Xref=ChEBI:CHEBI:60540;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000262};
CC       Note=Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme
CC       F430 is a yellow nickel porphinoid.
CC       {ECO:0000256|PIRNR:PIRNR000262};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction;
CC       methane from methyl-coenzyme M: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
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DR   EMBL; AM114193; CAJ37204.1; -; Genomic_DNA.
DR   RefSeq; WP_012035370.1; NC_009464.1.
DR   ProteinModelPortal; Q0W339; -.
DR   STRING; 351160.RCIX2063; -.
DR   EnsemblBacteria; CAJ37204; CAJ37204; RCIX2063.
DR   GeneID; 5144274; -.
DR   KEGG; rci:RCIX2063; -.
DR   PATRIC; fig|351160.9.peg.1075; -.
DR   eggNOG; arCOG04857; Archaea.
DR   eggNOG; COG4058; LUCA.
DR   HOGENOM; HOG000225809; -.
DR   KO; K00399; -.
DR   OMA; GRVCDGG; -.
DR   OrthoDB; POG093Z00ZI; -.
DR   BioCyc; MARV351160:G1GJJ-1075-MONOMER; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000000663; Chromosome.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.840.10; -; 1.
DR   Gene3D; 3.30.70.470; -; 1.
DR   Gene3D; 3.90.390.10; -; 1.
DR   InterPro; IPR016212; Me_CoM_Rdtase_asu.
DR   InterPro; IPR008924; Me_CoM_Rdtase_asu/bsu_C.
DR   InterPro; IPR009047; Me_CoM_Rdtase_asu_C.
DR   InterPro; IPR003183; Me_CoM_Rdtase_asu_N.
DR   InterPro; IPR015811; Me_CoM_Rdtase_asu_N_sub1.
DR   InterPro; IPR015823; Me_CoM_Rdtase_asu_N_sub2.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   Pfam; PF02249; MCR_alpha; 1.
DR   Pfam; PF02745; MCR_alpha_N; 1.
DR   PIRSF; PIRSF000262; MCR_alpha; 1.
DR   SUPFAM; SSF48081; SSF48081; 1.
DR   SUPFAM; SSF55088; SSF55088; 1.
DR   TIGRFAMs; TIGR03256; met_CoM_red_alp; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000663};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000256|PIRSR:PIRSR000262-1};
KW   Methanogenesis {ECO:0000256|PIRNR:PIRNR000262};
KW   Nickel {ECO:0000256|PIRNR:PIRNR000262, ECO:0000256|PIRSR:PIRSR000262-
KW   1}; Reference proteome {ECO:0000313|Proteomes:UP000000663};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000313|EMBL:CAJ37204.1}.
FT   DOMAIN        7    274       MCR_alpha_N. {ECO:0000259|Pfam:PF02745}.
FT   DOMAIN      322    447       MCR_alpha. {ECO:0000259|Pfam:PF02249}.
FT   METAL       153    153       Nickel. {ECO:0000256|PIRSR:PIRSR000262-
FT                                1}.
FT   MOD_RES     263    263       Pros-methylhistidine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
FT   MOD_RES     277    277       5-methylarginine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
SQ   SEQUENCE   556 AA;  60896 MW;  AF5A7C49E3699E34 CRC64;
     MAVKETQKRF IKAMKKKFAE EPTAQVTKFK YEGYTQSKRK VEFKKTGDAI AKKRGISMYN
     PMVHMGGIPL GQRQLMNYVV SGTDIAVEGD DLHFVNNAAM QQFWDEIRRT VIVGLDTAHA
     TLEKRLGKTV TPETISNYLA VLNHAMPGAA VVQEHMVETH PGLTDDCFVK VFTGDDELAD
     SIDKQYVLDI NKAFPKEQAA QLKKAIGKQL FQAVHIPTIV VRTCDGGTTS RWSAMQIGMS
     FIDAYKMCAG EAAVADLAFA AKHASVVEMG NLLPARRARG PNEPGGVSFG FLADIVQTHR
     KYPDDPVKSS LETVASGCML YDQIWLGSYM SGGVGFTQYA TAAYTDDILD DFCYYGYDYI
     KGKYGIAKAK PTMDVVNDIG TEVTLYGIEQ YEKYPTTLED HFGGSQRATV LSAAAGVTTS
     LATGNANAGL SAWYLSMYLH KEAWGRLGFF GYDLQDQCGA TNVFSCRSDE GAIDELRGPN
     YPNYAMNVGH QGGYTGIAGA AHYGRGDAWV ASPLIKIAFA DKSLAFDFTE PRKEFARGAI
     REFMPAGERS LVIPAK
//
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