ID Q0W6C2_METAR Unreviewed; 229 AA.
AC Q0W6C2;
DT 05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase {ECO:0000313|EMBL:CAJ36071.1};
DE EC=5.3.1.16 {ECO:0000313|EMBL:CAJ36071.1};
GN Name=hisA-1 {ECO:0000313|EMBL:CAJ36071.1};
GN ORFNames=RCIX677 {ECO:0000313|EMBL:CAJ36071.1};
OS Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanocellales; Methanocellaceae; Methanocella.
OX NCBI_TaxID=351160 {ECO:0000313|EMBL:CAJ36071.1, ECO:0000313|Proteomes:UP000000663};
RN [1] {ECO:0000313|EMBL:CAJ36071.1, ECO:0000313|Proteomes:UP000000663}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22066 / NBRC 105507 / MRE50
RC {ECO:0000313|Proteomes:UP000000663};
RX PubMed=16857943; DOI=10.1126/science.1127062;
RA Erkel C., Kube M., Reinhardt R., Liesack W.;
RT "Genome of rice cluster I archaea -- the key methane producers in the rice
RT rhizosphere.";
RL Science 313:370-372(2006).
CC -!- SIMILARITY: Belongs to the HisA/HisF family.
CC {ECO:0000256|ARBA:ARBA00009667, ECO:0000256|RuleBase:RU003657}.
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DR EMBL; AM114193; CAJ36071.1; -; Genomic_DNA.
DR RefSeq; WP_012036438.1; NC_009464.1.
DR AlphaFoldDB; Q0W6C2; -.
DR STRING; 351160.RCIX677; -.
DR GeneID; 5143384; -.
DR KEGG; rci:RCIX677; -.
DR eggNOG; arCOG00616; Archaea.
DR OrthoDB; 146815at2157; -.
DR Proteomes; UP000000663; Chromosome.
DR GO; GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd04723; HisA_HisF; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006062; His_biosynth.
DR InterPro; IPR044524; Isoase_HisA-like.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR43090; 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE; 1.
DR PANTHER; PTHR43090:SF2; 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE; 1.
DR Pfam; PF00977; His_biosynth; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|RuleBase:RU003657};
KW Histidine biosynthesis {ECO:0000256|RuleBase:RU003657};
KW Isomerase {ECO:0000313|EMBL:CAJ36071.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000663}.
SQ SEQUENCE 229 AA; 24493 MW; 2305EC34E83EDEB0 CRC64;
MFRCILACDL KGGVVVRGVR GEREKYRPIH EYSRLVTTSA PLEVIRTMRP KETYIADLDR
ITGAGDHLST ISDISAISST MVDAGISREE DAARLRKVSD SIIMGTETAS LSLIEALQAR
DVLVSVDMRH GQMMAADPAL PESPMMVVRR LNELDLGGII LLDIARVGSG EGIDLGLLSD
AASISRHPVI VGGGVRDVQD LEQMEKAGAA GAIIASAVHS LAIPLDLLR
//
