ID KEFB_ALKAM Reviewed; 661 AA.
AC Q0ZAH7;
DT 19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 13-SEP-2023, entry version 72.
DE RecName: Full=Putative K(+) efflux antiporter KefB;
GN Name=kefB; Synonyms=napA;
OS Alkalimonas amylolytica.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alkalimonas.
OX NCBI_TaxID=152573;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND GENE NAME.
RC STRAIN=N10;
RX PubMed=17600061; DOI=10.1099/mic.0.2007/007450-0;
RA Wei Y., Liu J., Ma Y., Krulwich T.A.;
RT "Three putative cation/proton antiporters from the soda lake alkaliphile
RT Alkalimonas amylolytica N10 complement an alkali-sensitive Escherichia coli
RT mutant.";
RL Microbiology 153:2168-2179(2007).
CC -!- FUNCTION: May operate as a K(+)/H(+) antiporter.
CC {ECO:0000269|PubMed:17600061}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. KEA (TC 2.A.37.1) subfamily.
CC {ECO:0000305}.
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DR EMBL; DQ649019; ABG37986.1; -; Genomic_DNA.
DR AlphaFoldDB; Q0ZAH7; -.
DR SMR; Q0ZAH7; -.
DR STRING; 152573.SAMN04488051_10349; -.
DR TCDB; 2.A.37.1.3; the monovalent cation:proton antiporter-2 (cpa2) family.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR46157; K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR46157:SF4; K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Potassium;
KW Potassium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..661
FT /note="Putative K(+) efflux antiporter KefB"
FT /id="PRO_0000425722"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 412..534
FT /note="RCK N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT DOMAIN 571..656
FT /note="RCK C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
SQ SEQUENCE 661 AA; 71766 MW; D11E8222F2AA8B2E CRC64;
MLLDGTLIQL LFLLGFMVFM VMLFQRAHIP ASIAYLLVGV LLGAHTAGPV ISEGYIHKIA
EFGIVFLLFT IGLRFSWQQI YQLRHTILGL GTAQVGLTTL LVALLLWAMG VASVVAFVIG
AVFAQSSTTI ISKQLLEQGE DQSRHGRLGI SLSVFQDITA VPFIIVIPVL GVAMAQDIAS
TLGMALFKAV LATALVVLVG RYLLRHLFHR VSSSDSAELF TLTVLLVCLA AAWLTQSLGL
SMAFGAFLAG MVMGETEFKL QVEAAIRPFR DVLLGIFFVS IGMLLDPMLL PEIGHIALAG
ALLLLLIKIV LVTALVLATG VALETAFRTG LILAVGGEFG FALLALALEG GTLDSRSSQI
ILTSVLLSMM LAVFLIRYNL QLSRFVVGRW IGQAAVSSEP FDDIEQHGLQ QHVVIAGFGR
IGQGVAQFLQ KEQVPYIGLD LDAARVKNAR LADVPVFYAD STDPDTLIAV GLAKARLLVI
SHEDLSAALT TLRHARTLHP DLPVIVRTRD ESHVAELRQA GATEVIPETI EAGMMLTSHV
LLMLNVPARR VNQLVQEQRI NRYQLLRQQF RGSADLLKTQ QQEQLKAVLL AEGSPAIDQS
LQMLDLAQYG IQLTELVRAH NRIEQPSLDM VLQENDVLVL FGSAEALEQA SLVLTHRLAA
D
//
