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Database: UniProt
Entry: Q11EL7_CHESB
LinkDB: Q11EL7_CHESB
Original site: Q11EL7_CHESB 
ID   Q11EL7_CHESB            Unreviewed;       457 AA.
AC   Q11EL7;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   08-MAY-2019, entry version 82.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   OrderedLocusNames=Meso_2782 {ECO:0000313|EMBL:ABG64158.1};
OS   Chelativorans sp. (strain BNC1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Phyllobacteriaceae; Chelativorans.
OX   NCBI_TaxID=266779 {ECO:0000313|EMBL:ABG64158.1, ECO:0000313|Proteomes:UP000001820};
RN   [1] {ECO:0000313|Proteomes:UP000001820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BNC1 {ECO:0000313|Proteomes:UP000001820};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R.,
RA   Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Richardson P.;
RT   "Complete sequence of chromosome of Mesorhizobium sp. BNC1.";
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
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DR   EMBL; CP000390; ABG64158.1; -; Genomic_DNA.
DR   RefSeq; WP_011582099.1; NC_008254.1.
DR   STRING; 266779.Meso_2782; -.
DR   EnsemblBacteria; ABG64158; ABG64158; Meso_2782.
DR   KEGG; mes:Meso_2782; -.
DR   eggNOG; ENOG4105C6Y; Bacteria.
DR   eggNOG; COG1004; LUCA.
DR   HOGENOM; HOG000153773; -.
DR   KO; K00012; -.
DR   OMA; RDLFHHD; -.
DR   OrthoDB; 647136at2; -.
DR   BioCyc; CSP266779:GI09-2799-MONOMER; -.
DR   Proteomes; UP000001820; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001820};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001820}.
FT   DOMAIN      315    416       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    262    262       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      30     30       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      35     35       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      86     86       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     121    121       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     154    154       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     265    265       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     329    329       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   457 AA;  49672 MW;  71E11E2A8430AEB1 CRC64;
     MQMTMIGAGY VGLTTGTCLA NLGHNVRCFD IDAARIGRLQ NFDIPIYEPG LQEAMRSAAK
     AGRLSFSDQL RESVAQADAV FIAVGTPSKP DGGIDLSHVL AAAQQMAPHL KRGSTVIIKS
     TVVVGTARRV REIIARERGA FDIRVASNPE FLREGSAMRD FMEPDRIVLG ADDTRSRNAL
     RAIYRSFERA GVPMVITTTG NAELIKYSAN AFLALKIGFI NDVADLCEKT GGDIGDVARG
     IGLDPRIGES FLLPGPGFGG SCFPKDTRAF AATGREFGAP QKLVETLITR NDQRKLLLAR
     RILKEGRFTP GSAVTVLGLS FKANTDDVRE AAALTIIPAL QEAGLRVIAH DPKAMANARK
     RLRDVTWVNC PYSACKETSA VVVLTEWDEY RQLDLGRIAR TLSGDALFDY RNLFEPRSVI
     QHGLRYFSLG RAASLRQKAG VSPIDTWDRR VAAPGHA
//
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