ID Q11IC2_CHESB Unreviewed; 768 AA.
AC Q11IC2;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=MscS Mechanosensitive ion channel {ECO:0000313|EMBL:ABG62853.1};
DE Flags: Precursor;
GN OrderedLocusNames=Meso_1457 {ECO:0000313|EMBL:ABG62853.1};
OS Chelativorans sp. (strain BNC1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Phyllobacteriaceae; Chelativorans.
OX NCBI_TaxID=266779 {ECO:0000313|EMBL:ABG62853.1};
RN [1] {ECO:0000313|EMBL:ABG62853.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BNC1 {ECO:0000313|EMBL:ABG62853.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.;
RT "Complete sequence of chromosome of Chelativorans sp. BNC1.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
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DR EMBL; CP000390; ABG62853.1; -; Genomic_DNA.
DR AlphaFoldDB; Q11IC2; -.
DR STRING; 266779.Meso_1457; -.
DR KEGG; mes:Meso_1457; -.
DR eggNOG; COG0668; Bacteria.
DR HOGENOM; CLU_013626_2_0_5; -.
DR OrthoDB; 9814206at2; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR045276; YbiO_bact.
DR PANTHER; PTHR30460:SF0; MODERATE CONDUCTANCE MECHANOSENSITIVE CHANNEL YBIO; 1.
DR PANTHER; PTHR30460; UNCHARACTERIZED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..768
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004180298"
FT TRANSMEM 115..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 491..531
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 533..599
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 603..689
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT REGION 712..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..768
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 82975 MW; 092C960817DF8509 CRC64;
MRILALLFLL ICASPVAAQS ANGASGAEAA ESPGDVEALI QILENDQART RLIQTLRQAE
TEEAAEEATP TGVLQIGEYA RAAVESSAAF ISAVVRLSGD ISDVLTGTTT VDFSIIWNAV
RTVIVVAVVT FSAFFLLRLG FLRIQRALAA AAAGSGPLRR SGLILASALF DTATVLLAWA
AGYVPAIYFD LADRAGGGQT LFLGAFLSVE LAKVVARVLL APRWPALRFL RIGDTTSAYW
YFWSSRLLSI LGYAFLFLAP LLASGVSYGA AQVLRAFVLF CALTMACIII MQNRDLVRSW
LMLGAERVKS EVISRALSIL ARFWNVVAIA YLILIFGLWL ADHEAALPFV LTATAQTFIA
IAIGTALTMA VTRIAAGGMH LPDDIRTRVP LLEQRLNAFV PNVLRVTRGV IVIGVIIASA
QIWLVADFLG WISSEVGQRI VTSILSAGII LIAGSLIYIV VQSWVEYRLD PPKGSKPSAR
ERTLLSLFRN AFTVALGVLT CMLVLSELGV NIAPLLAGAG ILGLAVGFGA QKLVQDIITG
AFIQFENAMN EGDVVTAGGV TGTVERLTIR SVSLRSLDGA YHLIPFSSVD SVSNFMKNFS
YHVANIGVDY GVSVPEVKRA MQDAFERLKK TEEGEHIIGE LEMHGVTEFG DSAIMVRARI
KTQAGRQWAI GRLYNEIIKE LFEERGIEIP FPHVTLNVSN EDLARLTKPL MDSTDSSEEA
MNSPAKAKPR APRNDGERPA VAAKRLRSRR PLQDGPPDDE HDLAEQQA
//
