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Database: UniProt
Entry: Q11VN4_CYTH3
LinkDB: Q11VN4_CYTH3
Original site: Q11VN4_CYTH3 
ID   Q11VN4_CYTH3            Unreviewed;       248 AA.
AC   Q11VN4;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   03-JUL-2019, entry version 90.
DE   RecName: Full=Urease subunit beta {ECO:0000256|HAMAP-Rule:MF_01954};
DE            EC=3.5.1.5 {ECO:0000256|HAMAP-Rule:MF_01954};
DE   AltName: Full=Urea amidohydrolase subunit beta {ECO:0000256|HAMAP-Rule:MF_01954};
GN   Name=ureA {ECO:0000313|EMBL:ABG58532.1};
GN   Synonyms=ureB {ECO:0000256|HAMAP-Rule:MF_01954};
GN   OrderedLocusNames=CHU_1260 {ECO:0000313|EMBL:ABG58532.1};
OS   Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469).
OC   Bacteria; Bacteroidetes; Cytophagia; Cytophagales; Cytophagaceae;
OC   Cytophaga.
OX   NCBI_TaxID=269798 {ECO:0000313|EMBL:ABG58532.1, ECO:0000313|Proteomes:UP000001822};
RN   [1] {ECO:0000313|EMBL:ABG58532.1, ECO:0000313|Proteomes:UP000001822}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33406 / NCIMB 9469 {ECO:0000313|Proteomes:UP000001822};
RX   PubMed=17400776; DOI=10.1128/AEM.00225-07;
RA   Xie G., Bruce D.C., Challacombe J.F., Chertkov O., Detter J.C.,
RA   Gilna P., Han C.S., Lucas S., Misra M., Myers G.L., Richardson P.,
RA   Tapia R., Thayer N., Thompson L.S., Brettin T.S., Henrissat B.,
RA   Wilson D.B., McBride M.J.;
RT   "Genome sequence of the cellulolytic gliding bacterium Cytophaga
RT   hutchinsonii.";
RL   Appl. Environ. Microbiol. 73:3536-3546(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+);
CC         Xref=Rhea:RHEA:20557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16199, ChEBI:CHEBI:16526, ChEBI:CHEBI:28938;
CC         EC=3.5.1.5; Evidence={ECO:0000256|HAMAP-Rule:MF_01954,
CC         ECO:0000256|SAAS:SAAS01115730};
CC   -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3)
CC       from urea (urease route): step 1/1. {ECO:0000256|HAMAP-
CC       Rule:MF_01954, ECO:0000256|SAAS:SAAS00108095}.
CC   -!- SUBUNIT: Heterotrimer of UreA (gamma), UreB (beta) and UreC
CC       (alpha) subunits. Three heterotrimers associate to form the active
CC       enzyme. {ECO:0000256|HAMAP-Rule:MF_01954}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01954}.
CC   -!- SIMILARITY: Belongs to the urease beta subunit family.
CC       {ECO:0000256|HAMAP-Rule:MF_01954}.
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DR   EMBL; CP000383; ABG58532.1; -; Genomic_DNA.
DR   RefSeq; WP_011584647.1; NZ_FPJX01000009.1.
DR   STRING; 269798.CHU_1260; -.
DR   EnsemblBacteria; ABG58532; ABG58532; CHU_1260.
DR   KEGG; chu:CHU_1260; -.
DR   eggNOG; ENOG4108YZ9; Bacteria.
DR   eggNOG; COG0831; LUCA.
DR   eggNOG; COG0832; LUCA.
DR   HOGENOM; HOG000075053; -.
DR   KO; K14048; -.
DR   OMA; SVTSHFH; -.
DR   OrthoDB; 1755809at2; -.
DR   BioCyc; CHUT269798:G1G6N-1236-MONOMER; -.
DR   UniPathway; UPA00258; UER00370.
DR   Proteomes; UP000001822; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00407; Urease_beta; 1.
DR   CDD; cd00390; Urease_gamma; 1.
DR   Gene3D; 2.10.150.10; -; 1.
DR   Gene3D; 3.30.280.10; -; 1.
DR   HAMAP; MF_01954; Urease_beta; 1.
DR   InterPro; IPR002019; Urease_beta.
DR   InterPro; IPR036461; Urease_betasu_sf.
DR   InterPro; IPR008223; Urease_gamma-beta_su.
DR   InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR   InterPro; IPR036463; Urease_gamma_sf.
DR   Pfam; PF00699; Urease_beta; 1.
DR   Pfam; PF00547; Urease_gamma; 1.
DR   PIRSF; PIRSF001225; Urease_gammabeta; 1.
DR   SUPFAM; SSF51278; SSF51278; 1.
DR   SUPFAM; SSF54111; SSF54111; 1.
DR   TIGRFAMs; TIGR00192; urease_beta; 1.
DR   TIGRFAMs; TIGR00193; urease_gam; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001822};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01954};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01954,
KW   ECO:0000256|SAAS:SAAS00108092, ECO:0000313|EMBL:ABG58532.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001822}.
SQ   SEQUENCE   248 AA;  26887 MW;  916A7D32EC025709 CRC64;
     MRLAPKDIEK LMLHNAGVLA QKRYARGILL NYPETIALLS AQLLEFIREG YSVAELMDLG
     MKILGVDDVM DGVAQMVDEV QIEGTFPDGT KLVTVHHPVC NQNLSNGYAL YGSGLTKSAS
     KLLIDNTINP TPGAKEYAAG TIELNAGRKT KILDVINSGD RPVQVGSHYI FSETNAALKF
     DRVGAIGYRL DIPAGTAVRF EPGEKKTVQV VEIAGQQIVY GGNGLIDGGI TEDDIPQIKQ
     RMQEKGFI
//
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