ID BAG7_YEAST Reviewed; 409 AA.
AC Q12128; D6W2J2;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 24-JAN-2024, entry version 162.
DE RecName: Full=Rho-GTPase-activating protein BAG7;
GN Name=BAG7; OrderedLocusNames=YOR134W; ORFNames=O3320, YOR3320W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8904341;
RX DOI=10.1002/(sici)1097-0061(19960315)12:3<281::aid-yea904>3.0.co;2-o;
RA Wiemann S., Rechmann S., Benes V., Voss H., Schwager C., Vlcek C.,
RA Stegemann J., Zimmermann J., Erfle H., Paces V., Ansorge W.;
RT "Sequencing and analysis of 51 kb on the right arm of chromosome XV from
RT Saccharomyces cerevisiae reveals 30 open reading frames.";
RL Yeast 12:281-288(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9200815;
RX DOI=10.1002/(sici)1097-0061(19970615)13:7<655::aid-yea120>3.0.co;2-i;
RA Voss H., Benes V., Andrade M.A., Valencia A., Rechmann S., Teodoru C.,
RA Schwager C., Paces V., Sander C., Ansorge W.;
RT "DNA sequencing and analysis of 130 kb from yeast chromosome XV.";
RL Yeast 13:655-672(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP FUNCTION, AND INTERACTION WITH RHO1.
RX PubMed=11591390; DOI=10.1016/s0014-5793(01)02906-4;
RA Roumanie O., Weinachter C., Larrieu I., Crouzet M., Doignon F.;
RT "Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins
RT from Saccharomyces cerevisiae.";
RL FEBS Lett. 506:149-156(2001).
CC -!- FUNCTION: Acts in signal transduction. Activates RHO1.
CC {ECO:0000269|PubMed:11591390}.
CC -!- SUBUNIT: Interacts with RHO1. {ECO:0000269|PubMed:11591390}.
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DR EMBL; X94335; CAA64053.1; -; Genomic_DNA.
DR EMBL; X90518; CAA62109.1; -; Genomic_DNA.
DR EMBL; Z75042; CAA99333.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA10908.1; -; Genomic_DNA.
DR PIR; S60988; S60988.
DR RefSeq; NP_014777.3; NM_001183553.3.
DR AlphaFoldDB; Q12128; -.
DR SMR; Q12128; -.
DR BioGRID; 34530; 57.
DR DIP; DIP-5208N; -.
DR IntAct; Q12128; 1.
DR STRING; 4932.YOR134W; -.
DR iPTMnet; Q12128; -.
DR MaxQB; Q12128; -.
DR PaxDb; 4932-YOR134W; -.
DR PeptideAtlas; Q12128; -.
DR EnsemblFungi; YOR134W_mRNA; YOR134W; YOR134W.
DR GeneID; 854302; -.
DR KEGG; sce:YOR134W; -.
DR AGR; SGD:S000005660; -.
DR SGD; S000005660; BAG7.
DR VEuPathDB; FungiDB:YOR134W; -.
DR eggNOG; KOG2710; Eukaryota.
DR GeneTree; ENSGT00950000183110; -.
DR HOGENOM; CLU_678279_0_0_1; -.
DR InParanoid; Q12128; -.
DR OMA; PEMAIDS; -.
DR OrthoDB; 25175at2759; -.
DR BioCyc; YEAST:G3O-33658-MONOMER; -.
DR Reactome; R-SCE-8980692; RHOA GTPase cycle.
DR Reactome; R-SCE-9013148; CDC42 GTPase cycle.
DR Reactome; R-SCE-9013149; RAC1 GTPase cycle.
DR BioGRID-ORCS; 854302; 0 hits in 10 CRISPR screens.
DR PRO; PR:Q12128; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q12128; Protein.
DR GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IDA:SGD.
DR GO; GO:0035024; P:negative regulation of Rho protein signal transduction; IGI:SGD.
DR GO; GO:0060237; P:regulation of fungal-type cell wall organization; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04396; RhoGAP_fSAC7_BAG7; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR PANTHER; PTHR15228:SF25; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 1: Evidence at protein level;
KW GTPase activation; Reference proteome.
FT CHAIN 1..409
FT /note="Rho-GTPase-activating protein BAG7"
FT /id="PRO_0000064810"
FT DOMAIN 76..235
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 409 AA; 46216 MW; 2B0BB821CD948E27 CRC64;
MFNMNLLSTP SSEEGSPQNR SSSMSSVEGK KDRDTFTNLQ NEFDGKVFGV SLEESLKVAQ
EEVIIQKSTN EIGSIPVVIA KSGKYLKENA LDTTGIFRIA GSNKRVRELQ AVFSKPPDYG
RKFEGWCDFN VHDIATLLKR YLNSLSEPLV PLALYDIFRN PILENPKINE HKEQIIKDYE
DIYMLLPQQN RHLILYLAAL LNLFARNEKK NLMSASNLAA IVQPSLLSHP KDEMCPKEYE
ASRTVIEFLI LHASDIIPNT EKANKDTMPH AGTVAKFNNI TVPEMAIDSD EEDFVHPSID
DHMLPRSRAL SDSNNFTIHH HHHHHHALFP SPIDFDNNGL SVPRSFKGRT LSAESLSPRL
SKLLGNVGNS SNTGIKDPTE RVPRGEHKTK HKQRQSWLRR LTSPSRTQP
//
