ID Q12KW8_SHEDO Unreviewed; 1979 AA.
AC Q12KW8;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Beta-hydroxyacyl-(Acyl-carrier-protein) dehydratase, FabA/FabZ {ECO:0000313|EMBL:ABE55908.1};
GN OrderedLocusNames=Sden_2629 {ECO:0000313|EMBL:ABE55908.1};
OS Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=318161 {ECO:0000313|EMBL:ABE55908.1, ECO:0000313|Proteomes:UP000001982};
RN [1] {ECO:0000313|EMBL:ABE55908.1, ECO:0000313|Proteomes:UP000001982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OS217 / ATCC BAA-1090 / DSM 15013
RC {ECO:0000313|Proteomes:UP000001982};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Richardson P.;
RT "Complete sequence of Shewanella denitrificans OS217.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SIMILARITY: Belongs to the thioester dehydratase family. FabA
CC subfamily. {ECO:0000256|ARBA:ARBA00006714}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
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DR EMBL; CP000302; ABE55908.1; -; Genomic_DNA.
DR RefSeq; WP_011497059.1; NC_007954.1.
DR STRING; 318161.Sden_2629; -.
DR KEGG; sdn:Sden_2629; -.
DR eggNOG; COG0304; Bacteria.
DR eggNOG; COG0764; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_30_0_6; -.
DR OrthoDB; 9778690at2; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000001982; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0008693; F:(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity; IEA:InterPro.
DR GO; GO:0008659; F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0034017; F:trans-2-decenoyl-acyl-carrier-protein isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01287; FabA; 2.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 4.
DR InterPro; IPR010083; FabA.
DR InterPro; IPR013114; FabA_FabZ.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43074; OMEGA-3 POLYUNSATURATED FATTY ACID SYNTHASE PFAB-RELATED; 1.
DR PANTHER; PTHR43074:SF1; PKS_AT DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07977; FabA; 2.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 4.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Reference proteome {ECO:0000313|Proteomes:UP000001982};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 6..464
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1002..1022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1097..1119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1979 AA; 214577 MW; 03003B66380BBF5B CRC64;
MSSHKLPKIA IVGLANQYPD ADTPAKFWQN LLDKKDSRSQ ISQQKLNANP QDYTGVQGES
DRFYCDRGGY IQDFTFNANG YQIPASAFEG LDDSFLWATD TARNALTDAG IGLSDSRLSR
TGIVMGTLSF PTAKSNELFV PLYHDVVEKA LQLKLGQPNF VLQGFSNEQP LGQTRSINYR
NGRIAHNASK LVADALGLGA AQLSLDAACA SSVYALKLAC DYLHTGKADI MLAGAVSGAD
PFFINMGFSI FHAYPDHGIS APFDSNSKGL FAGEGAGVLV LKRLEDAERD GDHIYALVSG
IGLSNDGKGQ FVLSPNSKGQ VLSFERAYRE ADIAPASIEV IECHATGTPL GDKVELTSME
RFFEDKLSGS ATPLIGSAKS NLGHLLTAAG MPGIMKMIFA MRQGVLPPSI NISSPIASPN
QLFGQQTLPN EVLPWPDKAG NKARHAGVSV FGFGGCNAHL LIESYDNDAA KSPTNTLQGQ
STLDAANTEL HITGIAAHFG KASSINVLAQ KITQQESLMT TLPAKRWKGL ERHPEILAQH
GLLAVPEGGY IDAFDFDFLR FKVPPNEDDR LISQQLLLMK VADEAINDAK LKPGSKVAVL
VAMETELELH QFRGRVNLHS QIAQSLKAQG VALTDDEYQA LETIAMDSVL DAAKLNQYTS
FIGNIMASRI SSLWDFNGPA FTISAGEQSV NRCIDVAQNL FALGSIQEPL DAVIIAAVDL
SGSIENILLK NASLAASGIQ MSDISARPWT VGEGAGAIVL QADASASSYA SINSLQFAST
DKAETLIAQV SGRVLTHPNA LIEINLSPES QFDPLAQTLV NKLAVGRNVV SQAQDLMGHS
FAASGMASLL HSLIHLNGQL NTSNDTGTQS AHANVVSISE NQCSNLDVSL SQTQQQSLSQ
RLTTPLTQQL SDTITTGSKL SLIKQVSLGG RDIYQHILDT PIAAIESIKA KCAMILPKVL
RTERSPAPKI LPMTQPTVQT HSLLPTSTET TQTIMPNLKS ASTASASQSA TTMQSATPKL
SATSLPPAHL SPFQQNQWLA QQAHFAFLKS RDAGLKVADS LLKHQLAQAN GSPQAVNVLA
SALPTQVTAT AQATSTQVSL NQAAPEHSTP VHSTPDHSSV PAYTAPIPAD KPCIWNYADL
VEYAEGDIAK VFGPDYAIID SYSRRVRLPT TDYLLVSRVT KLDAVMNQYK PCSMTTEYDI
PVDAPYLVDG QIPWAVAVES GQCDLMLISY LGIDFENKGE RVYRLLDCTL TFLGDLPRGG
DTLRYDIKIN NFASNGDTLL FFFSYECFVG DTLILKMDGG CAGFFTDQEL ADGKGVIHTE
AEIKARQDAM NNPNKPRFEP LLHCAQTQFD YCQIHHLLNG DIGSCFGGEH VGHQLQTGLQ
PSLCFASEKF LMIERVSKLD VRGGAWGLGL IEGHKQLAPD HWYFPCHFKG DQVMAGSLMA
EGCGQLLQFF MLHLGMHTKV SNGRFQPLEN ASQKVRCRGQ VLPQHGELTY RMEVTEIGLS
PRPYAKANID ILLNGKAVVD FQHLGVMIKE ESECTRYTQA SLTSTAASQG LTSTDTSQTH
KAPLMAQIPD LSAPVNKGVI PLKHVEAPVV AADSKYANRV PDTVPFTPYH MFEFATGDIE
KCFGPDFSIY RGLIPPRTPC GDLQLTTRVV EINGKRGELK KPSSCIAEYE VPADAWYFKN
NSHQSVMPYS VLMEISLQPN GFISGYMGTT LGFPGQELFF RNLDGGGKLL RHVDLRGKTI
VNDSKLLSTV IAGSNIIQSF TFELSVDGEA FYTGSAVFGY FKGDALKNQL GIDNGRVTQP
WHVEHNVPAN ISVNLLDKTS RVFNAPVNQP HYRLAGGQLN FIDKAEIVET GGKYGKGYLA
ASRTIDPSDW FFQFHFHQDP VMPGSLGVEA VIELMQTYAI SKDLGKGFTN PKFGQILSDI
KWKYRGQINP LNKQMSLDVH ISAVKDEDGK RIIIGDANLS KDGLRIYEVK DIAICIEEA
//
