ID   Q12U47_METBU            Unreviewed;       460 AA.
AC   Q12U47;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=Sodium/alanine symporter {ECO:0000313|EMBL:ABE53029.1};
GN   OrderedLocusNames=Mbur_2159 {ECO:0000313|EMBL:ABE53029.1};
OS   Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 /
OS   ACE-M).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanococcoides.
OX   NCBI_TaxID=259564 {ECO:0000313|EMBL:ABE53029.1, ECO:0000313|Proteomes:UP000001979};
RN   [1] {ECO:0000313|Proteomes:UP000001979}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6242 / NBRC 107633 / OCM 468 / ACE-M
RC   {ECO:0000313|Proteomes:UP000001979};
RX   PubMed=19404327; DOI=10.1038/ismej.2009.45;
RA   Allen M.A., Lauro F.M., Williams T.J., Burg D., Siddiqui K.S.,
RA   De Francisci D., Chong K.W., Pilak O., Chew H.H., De Maere M.Z., Ting L.,
RA   Katrib M., Ng C., Sowers K.R., Galperin M.Y., Anderson I.J., Ivanova N.,
RA   Dalin E., Martinez M., Lapidus A., Hauser L., Land M., Thomas T.,
RA   Cavicchioli R.;
RT   "The genome sequence of the psychrophilic archaeon, Methanococcoides
RT   burtonii: the role of genome evolution in cold adaptation.";
RL   ISME J. 3:1012-1035(2009).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363064};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU363064}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the alanine or glycine:cation symporter (AGCS)
CC       (TC 2.A.25) family. {ECO:0000256|RuleBase:RU363064}.
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DR   EMBL; CP000300; ABE53029.1; -; Genomic_DNA.
DR   RefSeq; WP_011500167.1; NC_007955.1.
DR   AlphaFoldDB; Q12U47; -.
DR   STRING; 259564.Mbur_2159; -.
DR   GeneID; 3997016; -.
DR   KEGG; mbu:Mbur_2159; -.
DR   HOGENOM; CLU_024867_1_2_2; -.
DR   OrthoDB; 77152at2157; -.
DR   Proteomes; UP000001979; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005283; F:amino acid:sodium symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR001463; Na/Ala_symport.
DR   NCBIfam; TIGR00835; agcS; 1.
DR   PANTHER; PTHR30330; AGSS FAMILY TRANSPORTER, SODIUM-ALANINE; 1.
DR   PANTHER; PTHR30330:SF3; TRANSCRIPTIONAL REGULATOR, LRP FAMILY-RELATED; 1.
DR   Pfam; PF01235; Na_Ala_symp; 1.
DR   PRINTS; PR00175; NAALASMPORT.
DR   PROSITE; PS00873; NA_ALANINE_SYMP; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU363064};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363064};
KW   Symport {ECO:0000256|RuleBase:RU363064};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363064}.
FT   TRANSMEM        20..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        73..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        102..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        153..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        196..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        253..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        319..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        360..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        390..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        419..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
SQ   SEQUENCE   460 AA;  49104 MW;  91F27415E39F8223 CRC64;
     MDLLNLFAAE TGILKSIDEI VWGIPLLSLL VGTGIYLTLS LGFIQIFKLP LALRYVVKPN
     ISDRKYTGDI SSFAALMTAL AATIGTGNIV GVATAIKIGG PGALFWMWLA AFFGMATKYA
     ESMLAVKYRN IDENGQMSGG PMYYITKGLA GKFYARPLAA FFAFSGIGVA FFGIGIFPQV
     NAIADSAAIT FNVPPIYTAA VVTVLVALVT IGGIKSIARV AQVVVPFMAI TYVLGCLLII
     FTNLDMLPDT IRLIITSAFT QTAATGGFLG ASMLLAVQMG IARGVFSNES GLGSAPIAAA
     AAKVKEPARQ GLISMTGTFF DTIIVCTMTG IVLVMTGSWT SEYEGAYMTS YAFSTGLENV
     GAYIVGIGLI FFAFTTILGW NYYGERCVEF LVGVKGILPY KIVYILLVGG GVFLTLETIW
     ILADIVNALM VIPNLIALLA LRKVIVNETR KYFEGLEKEN
//