ID Q12UC0_METBU Unreviewed; 344 AA.
AC Q12UC0;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Methylamine-specific methylcobamide:CoM methyltransferase {ECO:0000313|EMBL:ABE52956.1};
DE EC=2.1.1.- {ECO:0000313|EMBL:ABE52956.1};
GN Name=mtbA {ECO:0000313|EMBL:ABE52956.1};
GN OrderedLocusNames=Mbur_2082 {ECO:0000313|EMBL:ABE52956.1};
OS Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 /
OS ACE-M).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanococcoides.
OX NCBI_TaxID=259564 {ECO:0000313|EMBL:ABE52956.1, ECO:0000313|Proteomes:UP000001979};
RN [1] {ECO:0000313|Proteomes:UP000001979}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6242 / NBRC 107633 / OCM 468 / ACE-M
RC {ECO:0000313|Proteomes:UP000001979};
RX PubMed=19404327; DOI=10.1038/ismej.2009.45;
RA Allen M.A., Lauro F.M., Williams T.J., Burg D., Siddiqui K.S.,
RA De Francisci D., Chong K.W., Pilak O., Chew H.H., De Maere M.Z., Ting L.,
RA Katrib M., Ng C., Sowers K.R., Galperin M.Y., Anderson I.J., Ivanova N.,
RA Dalin E., Martinez M., Lapidus A., Hauser L., Land M., Thomas T.,
RA Cavicchioli R.;
RT "The genome sequence of the psychrophilic archaeon, Methanococcoides
RT burtonii: the role of genome evolution in cold adaptation.";
RL ISME J. 3:1012-1035(2009).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR EMBL; CP000300; ABE52956.1; -; Genomic_DNA.
DR RefSeq; WP_011500096.1; NC_007955.1.
DR AlphaFoldDB; Q12UC0; -.
DR STRING; 259564.Mbur_2082; -.
DR GeneID; 3997464; -.
DR KEGG; mbu:Mbur_2082; -.
DR HOGENOM; CLU_040933_2_1_2; -.
DR OrthoDB; 124836at2157; -.
DR Proteomes; UP000001979; Chromosome.
DR GO; GO:0043791; F:dimethylamine methyltransferase activity; IEA:InterPro.
DR GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:InterPro.
DR GO; GO:2001129; P:methane biosynthetic process from dimethylamine; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:InterPro.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:InterPro.
DR CDD; cd03307; Mta_CmuA_like; 1.
DR Gene3D; 3.20.20.210; -; 1.
DR InterPro; IPR048096; Methylcob_mtaseMtbA.
DR InterPro; IPR006360; Mtase_MtaA_CmuA.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR NCBIfam; NF041608; methylcob_mtaseMtbA; 1.
DR NCBIfam; TIGR01463; mtaA_cmuA; 1.
DR PANTHER; PTHR47099; METHYLCOBAMIDE:COM METHYLTRANSFERASE MTBA; 1.
DR PANTHER; PTHR47099:SF1; METHYLCOBAMIDE:COM METHYLTRANSFERASE MTBA; 1.
DR Pfam; PF01208; URO-D; 1.
DR SUPFAM; SSF51726; UROD/MetE-like; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methanogenesis {ECO:0000256|ARBA:ARBA00022994};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ABE52956.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABE52956.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 5..342
FT /note="Uroporphyrinogen decarboxylase (URO-D)"
FT /evidence="ECO:0000259|Pfam:PF01208"
SQ SEQUENCE 344 AA; 37112 MW; DF01A9BF112DD246 CRC64;
MTEYTPKTRL AAVLNQTEKV DRMPAICVTQ TGTVEQMEAC GIFWPEANYD AKMLAGLAAA
GHTEIGFEAI RVPFDITAEA EFFGCGIKDG TKVQQPSVIN HVVNSLDDLK PFEGYDINDS
SKRISTILES IKIVADEYGA ELPIIGSMIG PFSLAQHLTG DSWFMDIMTK EEYGLAIMEF
TTEFGIAYAN AQIDNGADTL SIIDPTASYS LIGGEFYKKF VVPFHAKLVE AMHARNVPVV
LHVCGDTTDG LAIMESAGVD AISVDQNVNA ATAVSKVEKA LIVGNLDPVN CLWNTSVETV
TAESERVLKE LDGKGLLAPG CGIVSQTPSA HLRAMVEVAK SYKY
//
