ID Q12YH9_METBU Unreviewed; 154 AA.
AC Q12YH9;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Riboflavin synthase {ECO:0000256|ARBA:ARBA00013950, ECO:0000256|PIRNR:PIRNR015750};
DE EC=2.5.1.9 {ECO:0000256|ARBA:ARBA00012827, ECO:0000256|PIRNR:PIRNR015750};
GN OrderedLocusNames=Mbur_0515 {ECO:0000313|EMBL:ABE51497.1};
OS Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 /
OS ACE-M).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanococcoides.
OX NCBI_TaxID=259564 {ECO:0000313|EMBL:ABE51497.1, ECO:0000313|Proteomes:UP000001979};
RN [1] {ECO:0000313|Proteomes:UP000001979}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6242 / NBRC 107633 / OCM 468 / ACE-M
RC {ECO:0000313|Proteomes:UP000001979};
RX PubMed=19404327; DOI=10.1038/ismej.2009.45;
RA Allen M.A., Lauro F.M., Williams T.J., Burg D., Siddiqui K.S.,
RA De Francisci D., Chong K.W., Pilak O., Chew H.H., De Maere M.Z., Ting L.,
RA Katrib M., Ng C., Sowers K.R., Galperin M.Y., Anderson I.J., Ivanova N.,
RA Dalin E., Martinez M., Lapidus A., Hauser L., Land M., Thomas T.,
RA Cavicchioli R.;
RT "The genome sequence of the psychrophilic archaeon, Methanococcoides
RT burtonii: the role of genome evolution in cold adaptation.";
RL ISME J. 3:1012-1035(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-
CC ribitylamino)uracil + riboflavin; Xref=Rhea:RHEA:20772,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15934, ChEBI:CHEBI:57986,
CC ChEBI:CHEBI:58201; EC=2.5.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000968,
CC ECO:0000256|PIRNR:PIRNR015750};
CC -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; riboflavin
CC from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-
CC ribitylamino)uracil: step 2/2. {ECO:0000256|ARBA:ARBA00004887}.
CC -!- SIMILARITY: Belongs to the DMRL synthase family.
CC {ECO:0000256|ARBA:ARBA00007424, ECO:0000256|PIRNR:PIRNR015750}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000300; ABE51497.1; -; Genomic_DNA.
DR RefSeq; WP_011498659.1; NC_007955.1.
DR AlphaFoldDB; Q12YH9; -.
DR STRING; 259564.Mbur_0515; -.
DR GeneID; 3998617; -.
DR KEGG; mbu:Mbur_0515; -.
DR HOGENOM; CLU_1682776_0_0_2; -.
DR OrthoDB; 23911at2157; -.
DR UniPathway; UPA00275; UER00405.
DR Proteomes; UP000001979; Chromosome.
DR GO; GO:0009349; C:riboflavin synthase complex; IEA:InterPro.
DR GO; GO:0004746; F:riboflavin synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd09210; Riboflavin_synthase_archaeal; 1.
DR Gene3D; 3.40.50.960; Lumazine/riboflavin synthase; 1.
DR InterPro; IPR002180; LS/RS.
DR InterPro; IPR036467; LS/RS_sf.
DR InterPro; IPR006399; Ribfl_synth_arc.
DR NCBIfam; TIGR01506; ribC_arch; 1.
DR Pfam; PF00885; DMRL_synthase; 1.
DR PIRSF; PIRSF015750; Ribfl_synth_arc; 1.
DR SUPFAM; SSF52121; Lumazine synthase; 1.
PE 3: Inferred from homology;
KW Riboflavin biosynthesis {ECO:0000256|ARBA:ARBA00022619,
KW ECO:0000256|PIRNR:PIRNR015750};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR015750}.
SQ SEQUENCE 154 AA; 16983 MW; 1DE87F6400C08B01 CRC64;
MKTIGIVDTT FARFNMGSAA VDEIQQNVSA KIKRITVPGV KDLPVASKKL IEEEGCDIVI
ALGMPGAKEQ DKICAHEAST GIIQAQLMTN THIIEVFVHE DEGKDEKELA FLMEMRSREH
ALNVVNMLFH PEKLVKQAGT GQRQGFEDVG TLKH
//
