ID Q13IB6_PARXL Unreviewed; 370 AA.
AC Q13IB6;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=Bxe_C0249 {ECO:0000313|EMBL:ABE36173.1};
OS Paraburkholderia xenovorans (strain LB400).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE36173.1, ECO:0000313|Proteomes:UP000001817};
RN [1] {ECO:0000313|EMBL:ABE36173.1, ECO:0000313|Proteomes:UP000001817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LB400 {ECO:0000313|EMBL:ABE36173.1,
RC ECO:0000313|Proteomes:UP000001817};
RX PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V.,
RA Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J.,
RA Parnell J.J., Ramette A., Richardson P., Seeger M., Smith D., Spilker T.,
RA Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M.;
RT "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome
RT shaped for versatility.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000272; ABE36173.1; -; Genomic_DNA.
DR RefSeq; WP_011493433.1; NZ_CP008761.1.
DR AlphaFoldDB; Q13IB6; -.
DR STRING; 266265.Bxe_C0249; -.
DR KEGG; bxb:DR64_8181; -.
DR KEGG; bxe:Bxe_C0249; -.
DR PATRIC; fig|266265.5.peg.8031; -.
DR eggNOG; COG1024; Bacteria.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000001817; Chromosome 3.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lyase {ECO:0000313|EMBL:ABE36173.1}.
FT DOMAIN 22..355
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 370 AA; 40860 MW; 51D22578D0DE9710 CRC64;
MNVNQQAETA AQELVIQEIN HVGVVTLNRP KAHNALTHAM VLALTERLSQ WKDDPAIYGV
VIRGAGDRAF CAGGDIRALY QSYRDGSPLY RDFFVDEYRL DHMLHQYPKP CVAVMDGLVM
GGGMGIAQGA ALRVVTSRSQ IAMPETAIGL FPDVGASYFL AKMPVELGLY LGITGVTLNA
ADALFAGLAD TFAESNHLND LDGLLSAITW TREPLADLRN AIRTGHRADS GRPSLEALMP
AIQHHFDPAR SIGQVIDSLD AERDPRYGEW ASTTAETLRQ RSPLMMCVTR EQLLRGRHAE
LADCFRMELG MVYRAFDDGD VIEGIRALLI DKDKAPRWRA ATVDEVTQPM VSRFFDSPWS
RDGHPLRDLA
//
