ID Q13NX7_PARXL Unreviewed; 350 AA.
AC Q13NX7;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE SubName: Full=Zinc-containing alcohol dehydrogenase superfamily {ECO:0000313|EMBL:ABE34212.1};
DE EC=1.1.1.2 {ECO:0000313|EMBL:ABE34212.1};
GN ORFNames=Bxe_B1754 {ECO:0000313|EMBL:ABE34212.1};
OS Paraburkholderia xenovorans (strain LB400).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE34212.1, ECO:0000313|Proteomes:UP000001817};
RN [1] {ECO:0000313|EMBL:ABE34212.1, ECO:0000313|Proteomes:UP000001817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LB400 {ECO:0000313|EMBL:ABE34212.1,
RC ECO:0000313|Proteomes:UP000001817};
RX PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V.,
RA Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J.,
RA Parnell J.J., Ramette A., Richardson P., Seeger M., Smith D., Spilker T.,
RA Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M.;
RT "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome
RT shaped for versatility.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000271; ABE34212.1; -; Genomic_DNA.
DR RefSeq; WP_011491556.1; NZ_CP008762.1.
DR AlphaFoldDB; Q13NX7; -.
DR STRING; 266265.Bxe_B1754; -.
DR KEGG; bxb:DR64_7059; -.
DR KEGG; bxe:Bxe_B1754; -.
DR PATRIC; fig|266265.5.peg.5992; -.
DR eggNOG; COG1064; Bacteria.
DR OrthoDB; 9771084at2; -.
DR Proteomes; UP000001817; Chromosome 2.
DR GO; GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05283; CAD1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR047109; CAD-like.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR PANTHER; PTHR42683:SF85; CINNAMYL ALCOHOL DEHYDROGENASE 6-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ABE34212.1}; Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 8..343
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 350 AA; 37963 MW; C0C32B11493C8069 CRC64;
MSTTYAYAAT DATAPLAPFE IQRRELRAHD VQMEVLFCGV CHSDLHQARN EWKNTVFPVV
PGHEIVGRVT AVGPDVTKHK VGDLVGVGCL VDSCRTCASC EEGLEQYCEN GFVGTYNGVD
RVDGQITYGG YSTQLVVDEE FTLSVPDNLD PAGVAPLLCA GITTYSPLRT WGAGPGKKVG
IVGLGGLGHM GVKLAHAMGA HVVLFTTSPS KIEDAKRLGA HEVVISKNAA EMEAHLNSFD
FILNTVAAQH DLNPFLNLLK RDGTMTLVGA PEHDHPSPQV FNLIFKRRRL AGSLIGGIAE
TQEMLDFCGE HGITSDIEVI PMQGINEAYE RMLKSDVKYR FVIDLDSLRK
//
