ID Q13PX4_PARXL Unreviewed; 509 AA.
AC Q13PX4;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Protein CyaE {ECO:0000256|PIRNR:PIRNR001892};
GN ORFNames=Bxe_B2121 {ECO:0000313|EMBL:ABE33865.1};
OS Paraburkholderia xenovorans (strain LB400).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE33865.1, ECO:0000313|Proteomes:UP000001817};
RN [1] {ECO:0000313|EMBL:ABE33865.1, ECO:0000313|Proteomes:UP000001817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LB400 {ECO:0000313|EMBL:ABE33865.1,
RC ECO:0000313|Proteomes:UP000001817};
RX PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V.,
RA Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J.,
RA Parnell J.J., Ramette A., Richardson P., Seeger M., Smith D., Spilker T.,
RA Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M.;
RT "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome
RT shaped for versatility.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC -!- FUNCTION: CyaE is necessary for transport of calmodulin-sensitive
CC adenylate cyclase-hemolysin (cyclolysin).
CC {ECO:0000256|PIRNR:PIRNR001892}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|PIRNR:PIRNR001892}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR001892}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613, ECO:0000256|PIRNR:PIRNR001892}.
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DR EMBL; CP000271; ABE33865.1; -; Genomic_DNA.
DR RefSeq; WP_011491220.1; NZ_CP008762.1.
DR AlphaFoldDB; Q13PX4; -.
DR STRING; 266265.Bxe_B2121; -.
DR KEGG; bxb:DR64_4450; -.
DR KEGG; bxe:Bxe_B2121; -.
DR PATRIC; fig|266265.5.peg.5609; -.
DR eggNOG; COG1538; Bacteria.
DR OrthoDB; 8553524at2; -.
DR Proteomes; UP000001817; Chromosome 2.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR028351; CyaE.
DR InterPro; IPR003423; OMP_efflux.
DR PANTHER; PTHR30026:SF20; OUTER MEMBRANE EFFLUX PROTEIN-RELATED; 1.
DR PANTHER; PTHR30026; OUTER MEMBRANE PROTEIN TOLC; 1.
DR Pfam; PF02321; OEP; 2.
DR PIRSF; PIRSF001892; CyaE; 1.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell outer membrane {ECO:0000256|PIRNR:PIRNR001892};
KW Cytolysis {ECO:0000256|PIRNR:PIRNR001892};
KW Hemolysis {ECO:0000256|PIRNR:PIRNR001892};
KW Membrane {ECO:0000256|PIRNR:PIRNR001892}; Signal {ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|PIRNR:PIRNR001892}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..509
FT /note="Protein CyaE"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004182507"
SQ SEQUENCE 509 AA; 52349 MW; 68D8025730249732 CRC64;
MRVRNGSIVA VVSSLLLTGC ATSALDMAPP RPDQPWSPAT TSSGEIIAGE RNQAGAANSY
VLPVNSALTN IPPPPAVDPT EVYSLSRLID VAESNNSATR IAWNDARRVA LAAGIAESTY
LPRITATAIG GFQGNSGSDS VQGVNFNNSG SANGTVSAVS LQWLLFDFGK RAAVVEAAKQ
ASVISNIAFN ATHQQVIYNV TLAFYTHAAA KARAATAAQS LSDAQAVQNA AEERYKHGIG
TVIEVAQARQ GTAQANLALV QATGGEQDAY LALLTAMGVS PLTHIKVADV AGRNLSPSMA
TSVEAIVSES LGRRPDVLGA YAARSASLAN IRAAQAEFMP KIFLSAIGSY NEGGLNLTAL
PSASQEPPTV NVNGHRFNGG IFVGLTIPIY DGGTRSAVLA QARADADSAD TRLTHVRDEA
VRQIVQADNA LRTSLSAYQA SKALAGAAQT TFDAALAAYH SGVGSITDLT LANSQLLQAR
NASTDAYSTA LSAAAMLALA TGTLGATPE
//
