ID Q143S2_PARXL Unreviewed; 429 AA.
AC Q143S2;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=Bxe_A3571 {ECO:0000313|EMBL:ABE29417.1};
OS Paraburkholderia xenovorans (strain LB400).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE29417.1, ECO:0000313|Proteomes:UP000001817};
RN [1] {ECO:0000313|EMBL:ABE29417.1, ECO:0000313|Proteomes:UP000001817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LB400 {ECO:0000313|EMBL:ABE29417.1,
RC ECO:0000313|Proteomes:UP000001817};
RX PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V.,
RA Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J.,
RA Parnell J.J., Ramette A., Richardson P., Seeger M., Smith D., Spilker T.,
RA Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M.;
RT "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome
RT shaped for versatility.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; CP000270; ABE29417.1; -; Genomic_DNA.
DR RefSeq; WP_011487187.1; NZ_CP008760.1.
DR AlphaFoldDB; Q143S2; -.
DR STRING; 266265.Bxe_A3571; -.
DR KEGG; bxb:DR64_1270; -.
DR KEGG; bxe:Bxe_A3571; -.
DR PATRIC; fig|266265.5.peg.893; -.
DR eggNOG; COG1024; Bacteria.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000001817; Chromosome 1.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lyase {ECO:0000313|EMBL:ABE29417.1}.
FT DOMAIN 34..374
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 429 AA; 46810 MW; 1437A2CB49447244 CRC64;
MNATPDFQSS SKPISPETGS TGSEVLFQVV NRVAVITLNR PAALNALSHL MVRDLANLLE
RVRNDDRIVA LVLRGGDPKG FCAGGDVRAL YQLARRGERD GENGWLQFFV DEYQLDHALH
RFPKPVVALL DGVTMGGGMG LGQAAQIRVV TTRTKIAMPE TRIGMVPDVG ATRFLAAMPL
ETELYVGLTG VTLSGADAVA CGLADLCVPG EWFDDFEGRL ERMRIEGNVL EALRAVFAPV
GVEGIPKATL PEYTPLISRH FDRRAGIEQI VSTLSAGLAR HPPQPEADWL LATLDALTQY
SPTMLMVTRE ALLRGRQMTL AECFRMELGI VSRAIGEGEF CEGVRAHLVD KDRKPRWAPA
KLAEVRAERV QHFLSSPWRN NTHPLAGLRD CDWPARETAK PGRGQCAGAN GEDSLCLSHS
GEMGRVRGM
//
