ID Q148E6_BOVIN Unreviewed; 511 AA.
AC Q148E6; F1MD72;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 27-MAR-2024, entry version 121.
DE SubName: Full=Cytochrome P450, family 4, subfamily B, polypeptide 1 {ECO:0000313|EMBL:AAI18399.1, ECO:0000313|Ensembl:ENSBTAP00000015892.4};
GN Name=CYP4B1 {ECO:0000313|EMBL:AAI18399.1,
GN ECO:0000313|Ensembl:ENSBTAP00000015892.4};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI18399.1};
RN [1] {ECO:0000313|EMBL:AAI18399.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hereford {ECO:0000313|EMBL:AAI18399.1};
RC TISSUE=Fetal lung {ECO:0000313|EMBL:AAI18399.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000015892.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000015892.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000015892.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000015892.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; BC118398; AAI18399.1; -; mRNA.
DR RefSeq; NP_001069670.1; NM_001076202.2.
DR STRING; 9913.ENSBTAP00000015892; -.
DR PaxDb; 9913-ENSBTAP00000015892; -.
DR Ensembl; ENSBTAT00000015892.5; ENSBTAP00000015892.4; ENSBTAG00000011976.5.
DR GeneID; 540149; -.
DR KEGG; bta:540149; -.
DR CTD; 1580; -.
DR VEuPathDB; HostDB:ENSBTAG00000011976; -.
DR eggNOG; KOG0157; Eukaryota.
DR GeneTree; ENSGT00940000161441; -.
DR HOGENOM; CLU_001570_5_1_1; -.
DR OMA; PLQWMKT; -.
DR OrthoDB; 1611592at2759; -.
DR TreeFam; TF105088; -.
DR Reactome; R-BTA-211935; Fatty acids.
DR Reactome; R-BTA-211958; Miscellaneous substrates.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000011976; Expressed in lung and 78 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd20678; CYP4B-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24291:SF149; CYTOCHROME P450 4B1; 1.
DR PANTHER; PTHR24291; CYTOCHROME P450 FAMILY 4; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 2: Evidence at transcript level;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 511 AA; 59290 MW; D71D0ACE8779E437 CRC64;
MVPVLLSLSL SHLSLWAFAL VSVLVFLKLT RLLLRRQMLA RAMDRFSGPP THWLFGHALE
IQQTGSLDKV VSWTHEFPYA HQLWVGQFLG FLNIYDPDYA KAVYSRGDPK APDFYDFFLQ
WIGKGLLVLQ GPKWFQHRKL LTPGFHYDVL KPYVALFAES TRVMLDKWEK KAREQKSFDI
YSDVGHMALD SLMKCTFGKG TSGLNDRDNN YYLSVKELTL LMQQRIDSFQ YHNDFIYFLT
PHGRRFLRAC QVAHDHTDQV IRERKAALQD EKERERIQSK RHLDFLDILL GAWDEEGIKL
SDEDLRAEVD TFMFEGHDTT TSAISWVLYC MSLYPEHQRR CREEIQEILG DRDTLKWDDL
AEMTYLTMCI KESFRLYPPV PQVYRQLSQP VNFVDGRSLP EGSLISLHIY ALHRNSTVWP
DPEVFDPLRF SPENVAGRHS FAFIPFSAGP RNCIGQQFAM AEVKVVTALC LLRFEFSPDP
SRLPIKMPQL VLRSKNGIHL HLKPLGPGSE K
//
