ID AKD1B_MOUSE Reviewed; 521 AA.
AC Q14DN9; Q8BZP7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2013, sequence version 3.
DT 27-MAR-2024, entry version 121.
DE RecName: Full=Ankyrin repeat and death domain-containing protein 1B;
GN Name=Ankdd1b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 93-521 (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 255-521 (ISOFORM 1), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-92 AND 126-217 (ISOFORMS 1/2).
RC STRAIN=C57BL/6J; TISSUE=Diencephalon, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q14DN9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14DN9-2; Sequence=VSP_046263;
CC -!- MISCELLANEOUS: [Isoform 2]: Sequence identified by Havana.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI12418.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; GL456167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC112417; AAI12418.1; ALT_INIT; mRNA.
DR EMBL; AK033960; BAC28528.1; -; mRNA.
DR EMBL; BB633264; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS88501.1; -. [Q14DN9-2]
DR RefSeq; NP_001036179.1; NM_001042714.1.
DR RefSeq; XP_006517745.1; XM_006517682.2.
DR AlphaFoldDB; Q14DN9; -.
DR SMR; Q14DN9; -.
DR PhosphoSitePlus; Q14DN9; -.
DR ProteomicsDB; 285799; -. [Q14DN9-1]
DR ProteomicsDB; 285800; -. [Q14DN9-2]
DR Antibodypedia; 71745; 56 antibodies from 12 providers.
DR Ensembl; ENSMUST00000055607.13; ENSMUSP00000061643.6; ENSMUSG00000047117.14. [Q14DN9-2]
DR Ensembl; ENSMUST00000239026.2; ENSMUSP00000159079.2; ENSMUSG00000047117.14. [Q14DN9-1]
DR GeneID; 271144; -.
DR KEGG; mmu:271144; -.
DR UCSC; uc007rmy.1; mouse. [Q14DN9-2]
DR AGR; MGI:2444730; -.
DR CTD; 728780; -.
DR MGI; MGI:2444730; Ankdd1b.
DR VEuPathDB; HostDB:ENSMUSG00000047117; -.
DR eggNOG; KOG4177; Eukaryota.
DR GeneTree; ENSGT00940000154170; -.
DR HOGENOM; CLU_000134_51_1_1; -.
DR InParanoid; Q14DN9; -.
DR OMA; SYQEHGN; -.
DR OrthoDB; 5479875at2759; -.
DR TreeFam; TF333615; -.
DR BioGRID-ORCS; 271144; 3 hits in 76 CRISPR screens.
DR PRO; PR:Q14DN9; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q14DN9; Protein.
DR Bgee; ENSMUSG00000047117; Expressed in mesodermal cell in embryo and 27 other cell types or tissues.
DR ExpressionAtlas; Q14DN9; baseline and differential.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR PANTHER; PTHR24125; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24125:SF5; REPEAT PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR SMART; SM00248; ANK; 10.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 8.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..521
FT /note="Ankyrin repeat and death domain-containing protein
FT 1B"
FT /id="PRO_0000332161"
FT REPEAT 60..89
FT /note="ANK 1"
FT REPEAT 93..122
FT /note="ANK 2"
FT REPEAT 126..155
FT /note="ANK 3"
FT REPEAT 159..190
FT /note="ANK 4"
FT REPEAT 194..223
FT /note="ANK 5"
FT REPEAT 227..256
FT /note="ANK 6"
FT REPEAT 260..289
FT /note="ANK 7"
FT REPEAT 293..322
FT /note="ANK 8"
FT REPEAT 326..355
FT /note="ANK 9"
FT REPEAT 359..388
FT /note="ANK 10"
FT DOMAIN 420..508
FT /note="Death"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
FT VAR_SEQ 259
FT /note="E -> ENGETPFLLAVVGGHEECSRVLLAGGSDVNIPNK (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_046263"
FT CONFLICT 153
FT /note="Q -> H (in Ref. 3; BB633264)"
FT /evidence="ECO:0000305"
FT CONFLICT 200
FT /note="H -> S (in Ref. 3; BB633264)"
FT /evidence="ECO:0000305"
FT CONFLICT 203
FT /note="A -> P (in Ref. 3; BB633264)"
FT /evidence="ECO:0000305"
FT CONFLICT 211
FT /note="I -> N (in Ref. 3; BB633264)"
FT /evidence="ECO:0000305"
FT CONFLICT 255..259
FT /note="NESNE -> ICSLQ (in Ref. 3; BAC28528)"
FT /evidence="ECO:0000305"
FT CONFLICT 313
FT /note="Missing (in Ref. 2; AAI12418)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 521 AA; 58456 MW; 72AE37B9DB204DE6 CRC64;
MNPESAQGHG ARAPMLQAAR GLKANLRDVA TRPWRSLARM PKPEVQDPET AAAGHEGLLA
IERSFQNAAK SSNLDLMEKL FEKKVNINAV NNMNRTALHF AVGRNSLSAV DFLLSHKARV
DVADKHGLTV IHLAAWSGSF EIMLMLVKAG ADQRAKNQEG MNALHLAAQN NNLHIVDYLI
HDLHLHDLNQ PNERGRKPFH LAAERGHVEM IEKLIFLNLH TSEKDKDGNT ALHLAAMHGH
SPAVQVLLTQ WSEVNESNEL NVSALQTATR NGHTALVNFL LGENADLQQQ KESKEPPLHL
AVINNRPAVV NSLLSARHDV DVLDQRRQTP LHVAADLGNV ELVETLLKAG CNLKITDKQG
KTALAVAARS QHSLVVDMLI KAERYYAWRE EHRESIQDSA VSSTLTFKQD HSLETRQIRT
LLWNLAYRQL KKKDWQRLAR LWSFTEDQIR AIEEQWSGND SFHEHGYRAL LIWLHGALLT
QLDPAKQLYE ELLCAGFPEL AEKIRQFKSK TDSSSKKCAV S
//
