ID Q16F49_AEDAE Unreviewed; 1088 AA.
AC Q16F49;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 121.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=AAEL014900 {ECO:0000313|EMBL:EAT32859.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT32859.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT32859.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT32859.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT32859.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT32859.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT32859.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT32859.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CH478512; EAT32859.1; -; Genomic_DNA.
DR RefSeq; XP_001649972.1; XM_001649922.1.
DR AlphaFoldDB; Q16F49; -.
DR STRING; 7159.Q16F49; -.
DR PaxDb; 7159-AAEL014900-PA; -.
DR VEuPathDB; VectorBase:AAEL014900; -.
DR eggNOG; KOG0892; Eukaryota.
DR HOGENOM; CLU_000178_3_1_1; -.
DR OMA; RQHFAIN; -.
DR PhylomeDB; Q16F49; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 26..630
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 734..1045
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 1056..1088
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 1088 AA; 124192 MW; 5E1BEF2050DE9296 CRC64;
MLTIVECIRM NNQNHSKHTI NLNWLQIAEA SLHCQAYFKA ILYGELWCMT QRDEGVESDV
ISRNPQLMSI MKTAHLSVGI VDAAKAFLDP IASRSEYYQL ERRFHQSLLY YDVASSSKST
FERSAYVQTL KASSFYGLAN TVANSESMDF ECAWRLADWN IALDDRANQG KQNVDWQHVF
EKQHYKALKC LELKDEIATE SAVLEARKAL AEMLKVGSME STQNIYPYLS KLRQLQQIED
FMNVQFYRVI DGETELLQKW DQQDTLPYSD FSYMEANLTQ RIAILKTARV RAMRKWVPDA
LNQTLFHLIH EARISGHFDV ATANICAMSQ QTLSETVKAL LMLEDAQLNW ANGDKFLSKR
LVNEVVAGGK CKDIMVNAAA YRIYGTFLAE THAEDVHNLY KKFFKHSQTL VEEGLRHASQ
HDKGTAIDYQ RKCLDSDRNF VILHTVAKYA DREFVRLKKH FTSSEFKSKK MNLEHMKAEL
IMLESEQAKL KESDREKMTN LRRAKISTKQ NATRDEESIN TMMSNMEDYL KLALFYYSAY
TRKTSIESDL AVFRIVALWL GNHSEKIADT VKESLKVIPT FKFVPVLPQL APRLDNHKEG
VGRMVWETLE RCAVDHPHHT LPHILAQVHA FADVERKDVP KDDERLLGAQ SLYHKLLKNK
KISAIVDQTT DMSLALIEMA NKILGTAKGF SDYKMTAKDA LRKCQGLDKV HCPTVELKVQ
ESGDYNEIIG VHKWDDLIHG VGGINAPKKL VCHCSDGHNR IQLLKGRDDM RQDAVMQQVF
CILNVLLRND KEAGKQKLAV RTYKVVPLSK QSGILEWCSN TIPIGSWLIP AHSRYRPKDL
TALDARKAFA ELAKSSLRTK QEKFLKICQQ LSPVFQHFFL ERFLTSGMWF ERRLAYTKSV
AVSSIIGYIL GIGDRHVQNI LVDEKTAEVI HIDFGIAFEL GKNLPTPETI PFRLTRDIVA
GMGISGIEGV FKKSCEKTLE ILRNNHAPIM TILEVLLYDP LYTWNVLANK KAARKQISEL
YGGEGGQDAR SEVVNISAER ALLRVSDKLN GKEDEKFTSV EGQVERLIFT ASSNLNLCQL
FQGWQPYL
//
