ID Q16FA2_AEDAE Unreviewed; 359 AA.
AC Q16FA2;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=Innexin {ECO:0000256|RuleBase:RU010713};
GN Name=5565409 {ECO:0000313|EnsemblMetazoa:AAEL014847-PA};
GN Synonyms=inx {ECO:0000256|RuleBase:RU010713};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:AIF75096.1};
RN [1] {ECO:0000313|EMBL:AIF75096.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=LVP-IB12 F19 {ECO:0000313|EMBL:AIF75096.1};
RC TISSUE=Malpighian tubule {ECO:0000313|EMBL:AIF75096.1};
RX PubMed=25585357; DOI=10.1016/j.cbpb.2014.11.013;
RA Calkins T.L., Woods-Acevedo M.A., Hildebrandt O., Piermarini P.M.;
RT "The molecular and immunochemical expression of innexins in the yellow
RT fever mosquito, Aedes aegypti: insights into putative life stage- and
RT tissue-specific functions of gap junctions.";
RL Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 183:11-21(2015).
RN [2] {ECO:0000313|EnsemblMetazoa:AAEL014847-PA, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL014847-PA,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:AAEL014847-PA}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL014847-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- FUNCTION: Structural component of the gap junctions.
CC {ECO:0000256|RuleBase:RU010713}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU010713};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU010713}. Cell
CC junction, gap junction {ECO:0000256|RuleBase:RU010713}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00351, ECO:0000256|RuleBase:RU010713}.
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DR EMBL; KJ736824; AIF75096.1; -; mRNA.
DR RefSeq; XP_001649755.1; XM_001649705.1.
DR AlphaFoldDB; Q16FA2; -.
DR STRING; 7159.Q16FA2; -.
DR PaxDb; 7159-AAEL014847-PA; -.
DR EnsemblMetazoa; AAEL014847-RA; AAEL014847-PA; AAEL014847.
DR GeneID; 5565409; -.
DR KEGG; aag:5565409; -.
DR VEuPathDB; VectorBase:AAEL014847; -.
DR eggNOG; ENOG502QR27; Eukaryota.
DR HOGENOM; CLU_035763_1_1_1; -.
DR InParanoid; Q16FA2; -.
DR OMA; IVNEECK; -.
DR OrthoDB; 2873211at2759; -.
DR Proteomes; UP000008820; Chromosome 3.
DR GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR InterPro; IPR000990; Innexin.
DR PANTHER; PTHR11893; INNEXIN; 1.
DR PANTHER; PTHR11893:SF41; INNEXIN INX2; 1.
DR Pfam; PF00876; Innexin; 1.
DR PRINTS; PR01262; INNEXIN.
DR PROSITE; PS51013; PANNEXIN; 1.
PE 2: Evidence at transcript level;
KW Cell junction {ECO:0000256|RuleBase:RU010713};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Ion channel {ECO:0000256|RuleBase:RU010713};
KW Ion transport {ECO:0000256|RuleBase:RU010713};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00351};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU00351}; Transport {ECO:0000256|RuleBase:RU010713}.
FT TRANSMEM 30..48
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT TRANSMEM 108..130
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT TRANSMEM 176..197
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
FT TRANSMEM 267..291
FT /note="Helical"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT ECO:0000256|RuleBase:RU010713"
SQ SEQUENCE 359 AA; 42038 MW; B721AC7FEF1A153C CRC64;
MFDVFGSVKG LLKLDQVCID NNIFRLHYKA TVVILIAFSL LVTSRQYIGD PIDCIVDEIP
LNVMDTYCWI YSTFTIPNRL TGIAGKDIAQ PGVSSHVDGH DEVKYHKYYQ WVCFVLFFQA
MLFYVPRYLW KTWEAGRIKM LVLDLNMPVV NDECKDERKK ILVDYFVENI NRHNFYAIRF
FICEVLNFVN VLGQIYFMDF FLDGEFSTYG SDVVRFTEME PEERGDPMAR VFPKVTKCTF
HKYGPSGSVQ KFDGLCVLPL NIVNEKIYVF LWFWFIILTI LTGASLVYRF AVVFMPKVRL
YLLRARSRLS EHDEVEMISS KCQLGDWFIL YQLGKNIDPL IYKEIISDLS LKFEGKEMV
//
