ID   Q16H69_AEDAE            Unreviewed;       495 AA.
AC   Q16H69;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 2.
DT   27-MAR-2024, entry version 101.
DE   RecName: Full=Serpin domain-containing protein {ECO:0000259|SMART:SM00093};
GN   Name=5563808 {ECO:0000313|EnsemblMetazoa:AAEL014138-PA};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL014138-PA, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EnsemblMetazoa:AAEL014138-PA, ECO:0000313|Proteomes:UP000008820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL014138-PA,
RC   ECO:0000313|Proteomes:UP000008820};
RG   Aedes aegypti Genome Working Group (AGWG);
RA   Matthews B.J.;
RT   "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AAEL014138-PA}
RP   IDENTIFICATION.
RC   STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL014138-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the serpin family.
CC       {ECO:0000256|RuleBase:RU000411}.
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DR   RefSeq; XP_001648088.2; XM_001648038.2.
DR   AlphaFoldDB; Q16H69; -.
DR   STRING; 7159.Q16H69; -.
DR   PaxDb; 7159-AAEL014138-PA; -.
DR   EnsemblMetazoa; AAEL014138-RA; AAEL014138-PA; AAEL014138.
DR   GeneID; 5563808; -.
DR   KEGG; aag:5563808; -.
DR   VEuPathDB; VectorBase:AAEL014138; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   HOGENOM; CLU_023330_7_1_1; -.
DR   InParanoid; Q16H69; -.
DR   OrthoDB; 3218836at2759; -.
DR   Proteomes; UP000008820; Chromosome 2.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd19597; serpin28D-like_insects; 1.
DR   Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR   Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461:SF342; SERINE PROTEASE INHIBITOR 28DC; 1.
DR   PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; Serpins; 1.
PE   3: Inferred from homology;
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900}.
FT   DOMAIN          96..493
FT                   /note="Serpin"
FT                   /evidence="ECO:0000259|SMART:SM00093"
SQ   SEQUENCE   495 AA;  55197 MW;  8BEE0BD2CB4B3B90 CRC64;
     MITRYSHVVT VVVIALASHL VNAQNRAGWV QNPPENAVYL QQQSQQPTVS QSRPIYFPQG
     QTINPARVST APPPPAPSFS QGQTKFQYDA ASFAVTELAR QVGAVLGQQS NAGVFSPVSI
     ACALSLLLLG ARDETRRELM QVLNFNPNDQ DPNGIHRQYG RLLQEIASTA PDAIPVAWRR
     NDRCSDEDDD DYKQESQITH LANAVFVQKD LKIDNSFIHW SRAFYNSSIK NLDFANNPQK
     SAFQINRWAH ENTFGKISQI VPNSVNPDTQ MIVANALYFK GLWKEVFEKQ ATGYKKFYPD
     GHANPSTAKD VLTMAAIGCF PYFDSPQYDA RIVGLPYQGD KTALYIIIPN NSSRQRMQQF
     QQRLTAKDIG AMVSQMTVRK ALVQIPKMKI SNTINLRDVL QKLRLRTIFS PSTSNLSAML
     DNSSGHERLY ASEIIHKVEL DVNEVGTEGG AITASTIFRS LPSVQIRVDT PFLMLVGHDA
     TRLPLFYGSI YDPTG
//