ID   Q16JP6_AEDAE            Unreviewed;       674 AA.
AC   Q16JP6;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   RecName: Full=MIF4G domain-containing protein {ECO:0000259|SMART:SM00543};
GN   Name=5577545 {ECO:0000313|EnsemblMetazoa:AAEL013249-PB};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL013249-PB, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EnsemblMetazoa:AAEL013249-PB, ECO:0000313|Proteomes:UP000008820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL013249-PB,
RC   ECO:0000313|Proteomes:UP000008820};
RG   Aedes aegypti Genome Working Group (AGWG);
RA   Matthews B.J.;
RT   "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AAEL013249-PB}
RP   IDENTIFICATION.
RC   STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL013249-PB};
RG   EnsemblMetazoa;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC       {ECO:0000256|ARBA:ARBA00005775}.
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DR   RefSeq; XP_001656561.1; XM_001656511.2.
DR   STRING; 7159.Q16JP6; -.
DR   PaxDb; 7159-AAEL013249-PA; -.
DR   EnsemblMetazoa; AAEL013249-RA; AAEL013249-PA; AAEL013249.
DR   EnsemblMetazoa; AAEL013249-RB; AAEL013249-PB; AAEL013249.
DR   GeneID; 5577545; -.
DR   KEGG; aag:5577545; -.
DR   VEuPathDB; VectorBase:AAEL013249; -.
DR   eggNOG; KOG0401; Eukaryota.
DR   HOGENOM; CLU_366916_0_0_1; -.
DR   OMA; NCIKILF; -.
DR   OrthoDB; 92033at2759; -.
DR   Proteomes; UP000008820; Chromosome 2.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:InterPro.
DR   Gene3D; 1.25.40.180; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045208; IF4G.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR   PANTHER; PTHR23253:SF9; EUKARYOTIC TRANSLATION INITIATION FACTOR 4G1, ISOFORM B-RELATED; 1.
DR   Pfam; PF02854; MIF4G; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820}.
FT   DOMAIN          235..474
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000259|SMART:SM00543"
FT   REGION          40..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          325..356
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          507..572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          598..674
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..71
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..92
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..355
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        518..542
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        598..614
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   674 AA;  74920 MW;  B71FBAC1D695646D CRC64;
     MADTVEPVVA DLQHQQPEED NNNQIDLADT VAKLSINGTA THDQQNNSCD ENEDNNNLDT
     STINNNVDGN HPSIGKRIRR TSEKLSGDEP GARKKYSLDQ LLSLKDTTIS REKPTTIPDA
     CRSILKSSHN PMMASSRNFG NQDNSLLPTF MRGMDGGGGM MNARPGPMKR APYQGRLSAK
     EMRSGGDDVD SGIIKVNLNI SEDVKLRECS NAWRPRFLQK QEELDEDSKK TQELFKKFRS
     VLNKLTPDNF NALVEQVKQY EIDTEERLDG CIKILFEKAI MEPNFTDTYA QMCKELGTII
     KIETSDNKQP NFKRKLITQC QKEFEKHHTD KEENASELEE SKKKAAEGEE KTEELNELQY
     ELEEKDAKIR RRAMGTIRFI GELFKQEQLT CKIMYTCINI LLSEEMLDEE ALECLCKLLT
     TIGGRMEKDS GQDSQSLQYY FDRLQEIADR KSTIQVSNRI RFMILDLMDL RKNNWQPRRA
     QAAPKTMDEI QKEVETEENK NRILNFVLSG SGGRGGGGRQ DGDRHHRYDG GSASKNKQRF
     VDDDGFVQPV SKNTSRQQLP MFDPKKLNLT QKSPEVTRLG SASMFQGWGK NNAFASLTDD
     QQQQQQQSSA GPPSFFGSGG FGGSSGGHSS GGGGGGGSKG GGGYGGGNKK SGGGGGGGGS
     GKKPMYNGRN SSRF
//