ID Q16K19_AEDAE Unreviewed; 1041 AA.
AC Q16K19;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=AAEL013142-PA {ECO:0000313|EMBL:EAT34626.1};
GN ORFNames=AAEL013142 {ECO:0000313|EMBL:EAT34626.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT34626.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT34626.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT34626.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT34626.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT34626.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT34626.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT34626.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00011003}.
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DR EMBL; CH477981; EAT34626.1; -; Genomic_DNA.
DR RefSeq; XP_001656381.1; XM_001656331.1.
DR AlphaFoldDB; Q16K19; -.
DR STRING; 7159.Q16K19; -.
DR PaxDb; 7159-AAEL013142-PA; -.
DR VEuPathDB; VectorBase:AAEL013142; -.
DR eggNOG; KOG2750; Eukaryota.
DR HOGENOM; CLU_293767_0_0_1; -.
DR OMA; DCQPLGV; -.
DR PhylomeDB; Q16K19; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P; 1.
DR PANTHER; PTHR12755:SF3; POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9; 1.
DR Pfam; PF16575; CLP1_P; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 709..858
FT /note="Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop"
FT /evidence="ECO:0000259|Pfam:PF16575"
FT REGION 1..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..182
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..279
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..378
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..440
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1041 AA; 117851 MW; 562EAAF1F342E9D0 CRC64;
MNKSRQESKA RNPSASFSKP GKALHHRNNK SAKAWKKGKS APEDEPADLE FKRMTNGMAN
RKNQMKSKAK SAQPIKPNVS KNLNKPEQNK PVKSQTEPKS KSESSQKRKA QNINGHGTKS
KKQKKHSSPE SDSDADDYID RFFGDISDDD AQVPAEESSE EDDLSESEDS ESEEDLEEES
TMSLEQLVDY YGHRRDAEQK TGKKRKQSHP AKGNNGGEWV EEDNDVELVY KDSDDEQGGN
SSRALVPAGD VRNVEYDEED DEEDLSSGDD EEDDDKFLEQ IMEPFDLEAY LRGENDFGEE
SDSSDEEEDL YGSDYTDSDS FEEDSEDASG EDQSDLDDHE FSSDYDSDED DASLEEDDDE
EFPSYWDESY DSEDDEDYVA EGVDDLYICR GTARVYNIDD NEVTFNSDVE TAQIVELPVE
DRRSRSVGSS ETESHEDAGN DGECPILVPI YDASGNIIDS PEKLEELKIN HAHGEKKQKS
RTSSVLIEMP ANHKETCNEA ETPELDQQDK MEEDVEQQNG ATEMYRFYDA IDMRLSLLIL
KETLYFSGHL TIQPLIGGLE VMGYNLSPGE CRSAFAVRGF HSLNLTPRVQ ATPSSKDAMG
KVMTRLEKHF HEADLKEIVN TFDSSDSVLV LLQADCNNKR IDTVDKYLSE DFLFPKVEYL
KKGTFFRTEY LLNVEFYLEH VDKSTSLYRP DPEWAKIVAK NNSKILVMGG KGSGKSTLCQ
YLINKNVEKF KKVVLIDLDI GQPIQHIPET ISITIIDRPL LGVATFNPIP PVKSWLFGSL
DIVSSLIFYT QNVHQLVRYC EQHKSELANI PWIINTMGYA TDFGEELMST ILRMLAPTDV
IQLVSTNKLL AIPNFQNRFT SEFINQYNYN ILRSEVKEYL QRKASFKHYE LNVCYPKKGF
SLNAPKRRNL MLLAHLADIL QDSSSEWFNE VKPFCAPLNQ LQVLITREDQ TLGDDQLPSV
LNATLVYLCR KDDAGLYECL GIGIVRGVDK NNNVYLLQSL PEARLAQVNV LAICSSSLPN
AVFLRQSTRI QGTIPYVYNI D
//
