ID Q16KN3_AEDAE Unreviewed; 889 AA.
AC Q16KN3;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 24-JAN-2024, entry version 96.
DE SubName: Full=AAEL012930-PB {ECO:0000313|EMBL:EAT34868.1};
DE Flags: Fragment;
GN ORFNames=AAEL012930 {ECO:0000313|EMBL:EAT34868.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT34868.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT34868.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT34868.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT34868.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT34868.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT34868.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT34868.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CNOT2/3/5 family.
CC {ECO:0000256|ARBA:ARBA00007682}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH477949; EAT34868.1; -; Genomic_DNA.
DR RefSeq; XP_001663118.1; XM_001663068.1.
DR AlphaFoldDB; Q16KN3; -.
DR STRING; 7159.Q16KN3; -.
DR PaxDb; 7159-AAEL012930-PB; -.
DR VEuPathDB; VectorBase:AAEL012930; -.
DR eggNOG; KOG2150; Eukaryota.
DR OMA; YKPQTPY; -.
DR PhylomeDB; Q16KN3; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0030015; C:CCR4-NOT core complex; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:2000036; P:regulation of stem cell population maintenance; IEA:UniProt.
DR Gene3D; 2.30.30.1020; CCR4-NOT complex subunit 2/3/5, C-terminal domain; 1.
DR InterPro; IPR038635; CCR4-NOT_su2/3/5_C_sf.
DR InterPro; IPR012270; CCR4-NOT_su3/5.
DR InterPro; IPR040168; Not2/3/5.
DR InterPro; IPR007282; NOT2/3/5_C.
DR InterPro; IPR007207; Not_N.
DR PANTHER; PTHR23326; CCR4 NOT-RELATED; 1.
DR PANTHER; PTHR23326:SF1; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3; 1.
DR Pfam; PF04153; NOT2_3_5_C; 1.
DR Pfam; PF04065; Not3; 1.
DR PIRSF; PIRSF005290; NOT_su_3_5; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 9..237
FT /note="CCR4-Not complex component Not N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04065"
FT DOMAIN 759..883
FT /note="NOT2/NOT3/NOT5 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04153"
FT REGION 244..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 50..77
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 250..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 889
FT /evidence="ECO:0000313|EMBL:EAT34868.1"
SQ SEQUENCE 889 AA; 96811 MW; 2AE8051E66C271FF CRC64;
LFLSFLNTGE IDRCLKKVTE GVETFEDIWQ KVHNATNSNQ KVRQYLLICT EKYEADLKKE
IKKLQRLRDQ IKSWIASGEI KDKSALLENR RLIETQMERF KVVERETKTK AYSKEGLGAA
QKMDPAQREK EEISSWLTTS ISSLQIQIDQ FECEVESLIA GKKKKLDKDK QEKMDELKGK
LERHKFHVTK LETLLRMLDN DGVEVEQIKK IKEDVEYYIE SSQEPDFEEN EYIYDDIIGL
DEVEISGMGP GGTESNNSNE TAGSPSSLIS GTSPSQSPPV KPTAIRPNKV DISALSATAG
SIAVSNSSST NNTSSSKPGL ISSTPSKNHA NAAAVVAGAV VPNIAGIVAP QAPPGGHVQT
IIGPAFAAVA KQHPKNGTLH PTSVTSSSTT SSVSSGQPSS AVAPNASGAA VSNLSQIVNA
SQPTLSQQLQ QALQQQQQQQ QTNLASSLLT NAASVVAGGN VPPQPTPQQS QQLPQQVPGQ
NSIPLPHGGA LTSASSGIEN NHVMTTSSAS TISSSGANII NNCVSPSNSA VSSRASPSLM
SPPQQQLLNG PTTLGKNATN HAVSMHIAST HPMSTLKNIA QEVINRTSGG LESSPSPVAS
STLVQQQASQ AGTQTQQQPP TVQQQPQRQP DTRQPGGQPV QSGQQQPGAQ QQQPPQQTQP
QQQPQQQQPF TLVDPANSAN SLIPTSSSTA ISNGPNAIIN TSTSIVANTA NPNVTSASMK
VSGTNEAHIP PLLGVAPLGP SPLQKEHQIQ FQMMEAAYYH LPTPSDSERL KSYLQRQPVQ
TPPHYPQQPL PHSDTVEFFQ RLSPETLFFV FYYMEGTKAQ YLAAKALKKQ SWRFHTKYMM
WFQRHEEPKI INEEFEQGTY IYFDYEKWGQ RKKEGFTFEY KYLEDRDLN
//
