ID Q16LB5_AEDAE Unreviewed; 1622 AA.
AC Q16LB5;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE SubName: Full=AAEL012701-PA {ECO:0000313|EMBL:EAT35114.1};
GN ORFNames=AAEL012701 {ECO:0000313|EMBL:EAT35114.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT35114.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT35114.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT35114.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT35114.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT35114.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT35114.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT35114.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CH477911; EAT35114.1; -; Genomic_DNA.
DR RefSeq; XP_001662815.1; XM_001662765.1.
DR PaxDb; 7159-AAEL012701-PA; -.
DR GeneID; 5576678; -.
DR KEGG; aag:5576678; -.
DR VEuPathDB; VectorBase:AAEL012701; -.
DR eggNOG; KOG0059; Eukaryota.
DR HOGENOM; CLU_000604_19_1_1; -.
DR OMA; ANCIMIV; -.
DR OrthoDB; 3685672at2759; -.
DR PhylomeDB; Q16LB5; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF250; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 3; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 240..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 856..880
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1023..1043
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1063..1088
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1100..1124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1136..1159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1165..1182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1236..1253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 487..717
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1304..1534
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1622 AA; 182474 MW; E053DD42797B959C CRC64;
MTSNWDKFVL LLWKNFLIHK RHRWRTCFEI GLPILVFSIV LMLPSKPHTV GPKRYPSLSV
DGGDGIPDHL RQLAYSPNNA VVEEIVSKAC AILGISQCDG FNSGLEMQTA MVNSSYLCGV
DFGDHSKTLS KVSNATTFKL RFPSELRYSS YGEPPSDWNT KQLSAPFTVS NYNPESIDGG
PPHYWHEHFL AVQAAISRVL VAKMAPTVQL PRSMNVQRFP YPTTVDNDLF VLLPYMLSNW
LRLVFMYFFI NSVKYIALEK ERQLKESMKL MGLPGWIQWG AWFVELLLMT LIPVTAITIM
LKVSIFPYST SFLIWTFLTL YCSSLICLCF LLSVFFNKAT RAATLASLLW IASFVSLPSG
APYWSKIVYS LLPNPAMGFG MDDIVRLETA GVGLTWQTLF KQTEMKNPYS LSIAVAMLLS
NILLYLLLTI YLEQVMPGKY GVAKPWYFPF TKDFWSRQSS ADVDLLLEPT ERSKYFEEET
QFRASGVQIR NLRKVYGSGK VAVDGLSLNL YEGQITVLLG HNGAGKTTTM SMLTGMFSPS
SGTALINGYD IRRRMDEVRG SMGFCPQHNV LFDELTVHEH LQFAARLKGI RSDEVRSQVD
RYINRLGLME KARAEASTLS GGMKRKLSVG MAMCGNPKVV LLDEPSTGVD PTARHALWDF
LHEEKRDKTV LLSTHYMNEA DVLGDRIAIL ADGKLSASGS PFFLKNAFGV GYRLICVKGR
KYSEACLLET LRKHIPSVKI DHESASEVEV LLEKKYVQRY EAMLEEMERN MESCGVMSYG
VSFTTLEEVF MKAGTESHNR SHDEGSRLTD HSVHLDTRAA NEPNSLLISS NNLKSSALAQ
IKAQFLKKFL CTKRSWIQFC WTTFVVPVVI MILVAFPIQI RTNNSLPPLE MSLATYDNSF
SVVEGSNSKA VHEYQRLFQD GQELEVLKTD TESYILQKYN GSILEYNSRL LVGASFSNDF
FTGWFNAKNL HSAPLALNLM FNAVLRTVCP SCSITTVNHP LPRQNDKNGD NTDNGDFLHH
LNIIIAIMFI MAYVPSSYVT FYIRERVNRV KLLQVVSGLR TELYWFVSIL WDLVAFMVCC
LVILTMLFGY QVDGWSDPQA LSILLFIFLI FALATLPMIY LISFTISNPA SGYSRVLLII
GIGAIGLLLV RLLFIYIEFN KLADLIGYGF MFIPTISLGL VFDKFSTYTS TVTTCNNLCN
LLPNCTMDVL CKQLPKCCSP YSDLFSFTSN GMLRELSFML VTGVVCFLLI WAIERKLLHR
LWAKVYPSKD YRYTVPQPQM DSDVLLEKSR ISQMTDTDIA AHSLVLRNLT KNYGPISAVK
WLSLGTQPSE CFGLLGVNGA GKTTTFRMMT GDESISFGDV WINGVNVKSN LAQAYQHVGY
CPQFDGLLDE LTGLETLRIF AMLRGIPGIY IDSVVRSHAE ELGLTMHLDK PIREYSGGTK
RKLSTALALI GNPSVIFLDE PTSGMDPGAK RQLWNVINRL RDAGRTIILT THSMDECEAL
CTRLAIMVNG EFKCLGSTQH LKNKFSGGFL LHIKMLQAPS QVELQIRMAA VKAFVAERFR
DAVLKEELQN SLSYHIPRSE LTWSAMFGIM EASKEVLAIE EYSLGQTTLE QVFLVFANSN
SW
//
