ID Q16N85_AEDAE Unreviewed; 1688 AA.
AC Q16N85;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Enhancer of polycomb-like protein {ECO:0000256|RuleBase:RU361124};
GN ORFNames=AAEL012057 {ECO:0000313|EMBL:EAT35803.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT35803.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT35803.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT35803.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT35803.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT35803.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT35803.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT35803.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. Involved in gene silencing by neighboring
CC heterochromatin, blockage of the silencing spreading along the
CC chromosome, and required for cell cycle progression through G2/M.
CC {ECO:0000256|ARBA:ARBA00025513}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU361124}.
CC -!- SIMILARITY: Belongs to the enhancer of polycomb family.
CC {ECO:0000256|ARBA:ARBA00008035, ECO:0000256|RuleBase:RU361124}.
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DR EMBL; CH477834; EAT35803.1; -; Genomic_DNA.
DR RefSeq; XP_001662169.1; XM_001662119.1.
DR STRING; 7159.Q16N85; -.
DR PaxDb; 7159-AAEL012057-PA; -.
DR VEuPathDB; VectorBase:AAEL012057; -.
DR eggNOG; KOG2261; Eukaryota.
DR OMA; NDIQSNW; -.
DR PhylomeDB; Q16N85; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR024943; Enhancer_polycomb.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR PANTHER; PTHR14898; ENHANCER OF POLYCOMB; 1.
DR PANTHER; PTHR14898:SF0; ENHANCER OF POLYCOMB-LIKE PROTEIN; 1.
DR Pfam; PF10513; EPL1; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361124};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361124};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361124}.
FT DOMAIN 7..141
FT /note="Enhancer of polycomb-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10513"
FT REGION 299..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1289..1309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1464..1490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1688 AA; 182002 MW; 698375C5E054D8DF CRC64;
MSKLSFRARA LDPSKPMPIY LAEELPDLPE YSAINRAVPQ MPSGMEKEEE SEHHLQRAIC
TGLIIPTPEV FEATDSEFYE KYYPTDYKMP KQMIHMQPLN LEQDVPDYDM DSADEQWVNT
QGKRLDLDPL KFETMMDRLE KSSGQTVVTL NEAKALLKQD DELSIAVYDY WLNKRLKTQH
PLILSVKTET RGNTTPNNPY LAFRRRTEKM QTRKNRKNDE SSYEKMLKLR RDLSRAVTLL
EMIKRREKIK REQLHLGIEI YEKRYQTQDF NGQLLSEFTA NATKASRPAF APIYSNQYSS
HHSAMSGSAG AGTSGSGAYH GPSSSSSHYH HVGGTSSSKR DSESLSSSRK EKRQYKKRKH
KIQKERSSAS SSTVTGSSAV GLGSSAVGTG GVGGYHHYQY HPAGTGVSGL SGIAASSGVG
GRGDAAVGTG LGSGTVDPAL SSDEEELANL QGATAPEEEY AYAFRRSKLS QYHRPITKGF
GDWPWVSKEE NGKADLRYRF ALTSLRHPRP RCIGFARRRI GRGGRVIIDR VSTDLDDLWS
RLDYKIIESE TTPAAAVAME PEEESIVIPV PSSAGASALT APTATATSNP TTASATTAIS
QMERKWNELE SALAVKSGVK RTRQLVIKEE TDMDDLFMAN FGLARRIKTD GLVKMEEEDV
VNSRLIGEEV EVKQEKCSDE RTSVAVAAGG TSSSTNSINN SLQNRAVSQY QQQLLQRSLR
ALQRKTAAPG LMSSASPDAS SSSRWNDELG LSESTPSADS KAIASVYTEL LNDIQSSWLH
FRPKTPEPML QMEDGLLDDD PLFQTDANRI ALELQALDAE LPGDIFNSTE SVYRTKNFAL
DSLVEPHPLG LESAAVTKDA TDELGIKLET CSNSDNNLSG DSLNDLNLSL SESNEDEKML
DKILQECQID DMKSLNQTSN FWNGILEDGI LNQLETADET GAGTGGDVKE DPLTINELVS
PSPVEGLPVH KIGYCSELVG YDRLASVERY KSKRRKILKR CNYLVGSSFF AVRNPPSEEI
FKKLSDGDGN VPLEGEKAEG AAEAAPTADS EVKVEEESDS VSATIPADQI KIEPPDELLA
ACSPSASSQS APHLQTNTSV PPVGSTYQQH SLSAPQIKLE PINYLQAVSH STAVAATASP
ATASTSFLIT SPSVQVVSQA TTTVLNPLVA SSQTTVPVVT AQHQQQQHPQ HSTLTGQITL
AGNAGSASSS GTSTPTGSYI VQHTTPIVLS QQQMQQIATS GGNIVTVSGN QMLTATKQAL
QQGQQQQHIQ LQHATHSHQG ETYVLTTATP TGQSPLKKQI NGPNDKTVKQ NVINPKLHTL
INQKLAASGQ KASDLSKKQF EMITKALVSQ KMIVKSATAA NHGSSAATAA AAQVVQQQQL
QQQQQGTSGT GTYNTIQNAA GLPITILSAT SQNPQQATQN KIILTSSPQL IQQAAGQLMA
AAAAASPHGK ISINSNLLQQ QQGQQLTQFQ TTDGGQGQTT SGTTGGQQQQ NVKFEKAVNM
LFDADKNRIV YANIKNSRGQ FLAQLNPKVV NIIQPIQQQK LINSVGAMQQ QQQQQTAANV
QSILGASPTG TTTFVNSKGG IQRIPSVSIR AQQLQQQQQQ QQQGQQQLDS HGTATVAVAT
NNATNSIKFI QVTPAVASAA SSVVSENQAV SSSGSGGLVV PSSSGAVVGT AGSGTNTAAP
TSINITNR
//
