ID Q16NK5_AEDAE Unreviewed; 601 AA.
AC Q16NK5;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
DE Flags: Fragment;
GN ORFNames=AAEL011944 {ECO:0000313|EMBL:EAT35934.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT35934.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT35934.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT35934.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT35934.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT35934.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT35934.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT35934.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
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DR EMBL; CH477820; EAT35934.1; -; Genomic_DNA.
DR RefSeq; XP_001662099.1; XM_001662049.2.
DR AlphaFoldDB; Q16NK5; -.
DR STRING; 7159.Q16NK5; -.
DR ESTHER; aedae-q16nk5; Carb_B_Arthropoda.
DR PaxDb; 7159-AAEL011944-PA; -.
DR GeneID; 5575613; -.
DR KEGG; aag:5575613; -.
DR VEuPathDB; VectorBase:AAEL011944; -.
DR eggNOG; KOG1516; Eukaryota.
DR OMA; AHIDEVY; -.
DR OrthoDB; 3035890at2759; -.
DR PhylomeDB; Q16NK5; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019826; Carboxylesterase_B_AS.
DR PANTHER; PTHR43142; CARBOXYLIC ESTER HYDROLASE; 1.
DR PANTHER; PTHR43142:SF1; CARBOXYLIC ESTER HYDROLASE; 1.
DR Pfam; PF00135; COesterase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW Serine esterase {ECO:0000256|ARBA:ARBA00022487}.
FT DOMAIN 35..532
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 601
FT /evidence="ECO:0000313|EMBL:EAT35934.1"
SQ SEQUENCE 601 AA; 67881 MW; BFE9928CB536E097 CRC64;
MVMRSALKKG WQNANTGSES QSHVARSCMP PSRVAVKVSQ GYIYGVRDAT TNGEHYYYFK
GIPYAKPPVG NLRFMSPVPI DKFPVTYLDC TAERGNCMGM DVISKEITGS EDGLYLNVYT
PVLPRSDGVS QNLPVMVYVH GGGLIGGHAD SSMYHPNYLL QEGVLVVTVN YRLGILGFLC
LPEAGIEGNA RLKDQRMALQ WVSQNISKFG GDPNNVTLFG ASSGAIAVNM HCLSKESKKY
FHKAIMQSGS IYLEWGHQEK PEQKARKMAE LLGASPTTDE EVYQVLKNAP ARKLFELQFK
AVTEREELVE KLFQIPFLPV VEREQSSDAI ITKHPTEIMR DPDGVGIPII QGYNEYDGMM
VLLDAVKNPN MYNLQPERFI PRTLNVDCYA PEARKLAMEI KKAYFGDQDV SRETVMQLVE
LFTDKYILSY RISFELWAKY QTKAKMFGYR FSFDGLLNKG KAIMSFGSLK GTCHIDEVYY
IFSSPILRTE VPKTSKAYEM RNKMVHMWGN FARCSDPTPD GDMELSFKWN PVPQIPVDLE
DVRCTLLSIS APDEIGMAEM PERERMEYWT ELYRKYNGHV TNILVPTVPL LDSVDLNNNS
V
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