ID Q16P14_AEDAE Unreviewed; 1154 AA.
AC Q16P14;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 24-JAN-2024, entry version 90.
DE RecName: Full=Protein tweety homolog {ECO:0000256|RuleBase:RU361114};
GN ORFNames=AAEL011800 {ECO:0000313|EMBL:EAT36087.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT36087.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT36087.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT36087.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT36087.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT36087.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT36087.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT36087.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable chloride channel. {ECO:0000256|RuleBase:RU361114}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the tweety family.
CC {ECO:0000256|ARBA:ARBA00009849, ECO:0000256|RuleBase:RU361114}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361114}.
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DR EMBL; CH477800; EAT36087.1; -; Genomic_DNA.
DR RefSeq; XP_001661912.1; XM_001661862.1.
DR AlphaFoldDB; Q16P14; -.
DR PaxDb; 7159-AAEL011800-PA; -.
DR VEuPathDB; VectorBase:AAEL019973; -.
DR VEuPathDB; VectorBase:AAEL019974; -.
DR eggNOG; KOG4433; Eukaryota.
DR HOGENOM; CLU_004342_0_0_1; -.
DR OMA; NANLCEE; -.
DR PhylomeDB; Q16P14; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR006990; Tweety.
DR PANTHER; PTHR12424:SF18; PROTEIN TWEETY-2; 1.
DR PANTHER; PTHR12424; TWEETY-RELATED; 1.
DR Pfam; PF04906; Tweety; 1.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|RuleBase:RU361114};
KW Chloride channel {ECO:0000256|RuleBase:RU361114};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU361114};
KW Ion transport {ECO:0000256|RuleBase:RU361114};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361114};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361114};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361114};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361114}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 54..71
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 184..205
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT TRANSMEM 212..236
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361114"
FT REGION 608..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 301..328
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 617..664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..935
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1052..1125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1154 AA; 129141 MW; 91B27B7979C5720E CRC64;
MAKLIACGSL GILASIPAAL LIISLVFLLL YLLTRCCDRK PRKPKSHGCQ KCTLVFFAIV
CCAAIGLGLY GNDDLHNGVL QIFGSGRKIE ELILSVRNQT EMVKYNLKTK VVLSELEAKF
EKPPQMYNQT AQYLLQDTVK MVKDNTTMAI NALETVVYLT RPSHSEMTLN SLLNTYEFYE
ELRWPATLGF LTFLLLLCII LVIGATRSSR CALIFFSVCG LLAVTVCWLL SGIYLASAVA
LGDFCMKPND FICSQVRTNF LLVSVGTNRY VLRLNESKDY LDRAKEALDI MNRIAINLYP
RFEMSSKINR LSEELDDSKR QLIALSARAD RRAVMEHYAN ATRGLCEGGL FGLTLMLLAS
LVSAAILSLL VCVDSHTWIY LTKKRPYEDK SETAPLFPAG AATASPASAQ ITAGTMTVNR
TLLHAQAATS NGTTGGTLIP SSGRNGTTHG LRGLASYSGD ESPPPDYNVV VHDNRHGFFI
LASGHHTLGR LPSQQSHLAG PNNGKYATLS KQCSNKLGEF GTPTISHSNA PTAKRVLANE
PPVDTFADKK LTASTATLAD KDPRDISNNG FNRFDPKYVS IGPKAVRTSS NQTMVNLNKC
ATLRAHGRYA SGGRGTSPSP HLKSVQQPMV AHSQFNKPQT QHTQLQDKPE RQATTQPKLN
ISTVSKDYNQ SYSCATLPYK KPSGFADGPT TSILKKESNL DSKHQHPTVY SIDTSHHQPA
PQPTQHHRSL SSTNQLYHET GAGSTFASPP PSSASTATTK SNISIINQPL PEIPTAAQQN
SSSLKNNQQP LCAATLNQYR SLQRPSKQSS LSVKEVQQKP SIPPKVTPPM LPPKNRHKDE
SLYQSRTSSV SSSTGRPQQP LPQPPSHQSS SSSLQSYGHV VSASGKTNFN AIQLQLQNQL
HFKQYHQLTQ QPWQREQLSM QQQHAAASGY QTHDSRYEQK SNRNRSYSGS SEREQQQQQQ
HHQQQLQQQQ QQYQKPSGEK QKQSYQTLPK NHHHHSSNTT SFSTQTQPQP LQQPVPHHHH
HPLPPQQQQQ QQQSQQAVTQ QPQQPKSILS KSRSNEARER EREHRERERE RERERDRDRD
RDRDRDRDRD RDRDRDRDRD RDRERERSSH RGHSHEYHHD SRSVDSNKNP NVYYRSLQRG
GLQANNDLYS VTEL
//
