ID Q16QK6_AEDAE Unreviewed; 1796 AA.
AC Q16QK6;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=AAEL011253-PA {ECO:0000313|EMBL:EAT36687.1};
GN ORFNames=AAEL011253 {ECO:0000313|EMBL:EAT36687.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT36687.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT36687.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT36687.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT36687.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT36687.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT36687.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT36687.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CH477745; EAT36687.1; -; Genomic_DNA.
DR RefSeq; XP_001661534.1; XM_001661484.1.
DR STRING; 7159.Q16QK6; -.
DR PaxDb; 7159-AAEL011253-PA; -.
DR VEuPathDB; VectorBase:AAEL011253; -.
DR eggNOG; KOG1452; Eukaryota.
DR eggNOG; KOG3528; Eukaryota.
DR HOGENOM; CLU_002292_0_0_1; -.
DR OMA; NQHGNHR; -.
DR PhylomeDB; Q16QK6; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00030; C2; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd04379; RhoGAP_SYD1; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46150; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR PANTHER; PTHR46150:SF3; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
FT DOMAIN 134..204
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 717..841
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 881..1081
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1165..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1217..1359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1416..1468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1636..1672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1696..1796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1224..1254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1262..1290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1309..1359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1416..1449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1640..1670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1696..1783
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1796 AA; 189968 MW; 4253B473B1683447 CRC64;
MPSSHQQQQQ PGQGIMQQRN QYGQLQQGGS GGEQRGMGGP GPGGGGSGSG SNKEPVLLQG
DFRKVSGISS EIFRQIEAVE NDHDPSTAAA LEAVERRGEM IVRILEPRCM GSRQAVEAGQ
KFLNKADARH TVQLVEIVKR PGQTLGLYIR EGNGADRSDG VFISRIALES AVYNSGCLRV
GDEILAVNLV DVTRMSLDDV VIIMSIPRRL VLAIRQRRGS RGANSPGPPQ MSRPEQKPPP
VVVIKRDLRD DDLDDSDRAP RSSRSTRVRR MGDGREMTQS HSRMGLGINS YSPQSEQLDL
YYGPRQGQSV ETPSWGYKPP PPPSVITEQP KGTHGFQTSH SYYQNAGTLE SLAEKVHSFY
PSANRRMSAG TGVTMSQSHQ RFPRSGSDQH LPRVEYADYQ SLGRHTLLRS SLKSDLVQAA
PIAGGTLDRY GRYEPPPSSR TPKYGPSPLG ATGSLQRRSR PALDYSSDTE ATIGPRPSYY
YYNHPAMANT IARGSTQALG GGPEYAKFNS LPRDRPGSRM GLRSRIGERL QDENDGNLSA
PEYSLPIRRD PRDLRQRLTA SPSIFTSDEY RAWLRRAPSS SAICEQMRAS RDILNQQRAH
RFSCSAENIH DVLKNTENIY SSRTALTGGT LDRHGLTGAG GPRMSSLPVR SMSSQHIGPS
SIRSPSVRRM RQLLELTQAG PGGVPGSAMA ALTGHQSPAP TPSTTLPRTH RQIDINPAEY
TKYKLDKPVV DAIGMSGMLW IHLLAGRGLR AMSETSQAQQ PMIRDLYCVL ECDRIHKART
VVRSGDLQFD WDESFELDLV CNKQLDVLVY SWDPQHRHKL CYRGALSLTT LLRQSPIHQL
ALKVEPRGTI YLRLRHTDPF QLYRRRGLPS LRGNVPALFG ADLETVVTRE SKGAPGSAPV
PIILRRCVEE VERRGLDIIG LYRLCGSATK KRLLREAFER NSRAVELTPE HVPDINVITG
VLKDYLRELP EPLFTKCLFQ MTVDALGVCL PDDPEGNAKL MLSILDCLPR ANRATLVFLL
DHLSLVVSAS ERNKMSAQAL ATVMGPPLML HSSSAGPNEE IDHAQPIAVL KYLLQIWPQP
QHGHVGGTSV GKSPALHPSL PSSLGAAPLS LSSSSLSLSS NTSHRSQLHQ PSSAAAAAAA
AASSSLSAAS GTAAAAAAEH ISRSVASSPS TTSLQHGPRP LSATPSSLQY QSVVAQLAQS
HRASPQAVPQ PHLLEGSAAS AEHGQSPRHV TPSPSSSSTS SASGSGSGTD TIKRGASPAS
VKFKESGSSY SLKSDTSRIL SSSGSLAKKY TPNGAGNGGE PIANGSSPYE HHPPSSSSST
LLGNGNGAIR KQQQHQRDGN GSTSSTINNG PNISSSSDLQ LPSRSVLFSS DYLSSTSTSS
TSVTTATTAA SVTKPMAPLS TLDVATFSLD EKNNLVVSPS PSSASESSHH SSNSSLRERS
PQPSPSLKRQ EPVDRTDSVT STSTGGSSLF SSLRSQTLGS YQFPSSTLKL SSQLSADSAT
SSADDGSTSS LLRKLTTSLS RSITSNTGTL PLSLGRQSAS SALYQQDISY SGGSSSGKST
SASLNYASPA GGSSLLSGGE GNGSSAVTTA AAVSSMSIYG TLPKNSSIYS YGGTSSSLLT
GTSSSYGISD RLRALTGSGS GSAGEDSSSG LGSSMTTTTT SSSSGVDSGA GSSAADLGAS
GYDYESSGFS STGLTSSYGA TSASPSVSMT TSAGSGLSSS YFSTGSGSSP FGGNGGETTS
SSGPPTYRVQ YSSTNPFLPS YNPPSDNGAG ATGNGVTSGR NGGLRSSDED DSFDMK
//
