ID Q16QK8_AEDAE Unreviewed; 1907 AA.
AC Q16QK8;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=AAEL011258-PA {ECO:0000313|EMBL:EAT36685.1};
GN ORFNames=AAEL011258 {ECO:0000313|EMBL:EAT36685.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT36685.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT36685.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT36685.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT36685.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT36685.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT36685.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT36685.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; CH477745; EAT36685.1; -; Genomic_DNA.
DR RefSeq; XP_001661532.1; XM_001661482.1.
DR STRING; 7159.Q16QK8; -.
DR PaxDb; 7159-AAEL018215-PA; -.
DR VEuPathDB; VectorBase:AAEL018215; -.
DR eggNOG; KOG1998; Eukaryota.
DR HOGENOM; CLU_000595_2_0_1; -.
DR OMA; MRDFGHS; -.
DR PhylomeDB; Q16QK8; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF12; SPONGE, ISOFORM E; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 290..466
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1085..1494
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1551..1592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1648..1687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1701..1722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1743..1816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1556..1581
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1648..1670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1767..1805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1907 AA; 216866 MW; 6F680199A0CB3268 CRC64;
MPLHGDDDDN SIPTCTKLPI LDIKLGLDLV PRLGTLAVDP HKIGIVSLHQ VHVNSAENAK
AASNRGTLRR KAGKKILTHH LYFCMRDFGH RIGDDAEIYF YLYDGQRMRA LSERFLVRIA
KDGFSNYVET SHNCTVFTDL GSSDLNQDLY LIANVMRVGK MLHSESVKKG DKFISNHSYR
RPYGIGVLPL SEIGQFDQTV ESEEKEFSFK IFQCEEKDYH QLHELIIKKA SGKFQPINAT
TQGHYGLVVS LKLIHGGLGQ ARIEQPILFQ GTAITKKIGF PDVIMPGDVR NDLFLTLERG
EFERVGISTA KNIEITTLVL DENGRIIQEC IAIASGNPLQ AYYKSMVLYH NNSPAWNETI
RMFVPIDKFS KAHVRFEFRS CSTRDKSDPK LFGFSFSRLM EPGGATLADA LHELYVYKCE
DILKVQPNIY LRLPCSATDK HAHTLESNSP YHRSSKEAFF VKTVLCSTKL TQNGDLLSIL
QWRNHPHRIQ DSLQRVLRLH NEELIKFLQD VLDALFAMFS TDDGNSTPHS GLVFHVLVSI
FSLMQSSKFQ HFKPVMDAYI KDHFTAPLVY KGLLSSVQHL ADWMNTADNL EPILQCFSSL
EFIFKLIIQS RKLFAHASGG QYEDKFKHDL FAVFTSLNGM LLVASHSQIL PTQEALLSSI
GVVFEQLRTI ITKTELETLV KGMLDSVPKD AQPPLIQAKL KSIKDMVSGQ LFQDDELRSV
ILNIACKHLR IHLARRDELR LCSEILAEIL IKLHEAKVRT GEKPSNAIHH DLDTLFSNIF
PILMQTINVL GNGGNESLVC ALFAVMLGLL QLLEETHFQR MWDRLSTAGN NKELKDFIQQ
CLNIFKDILE QDWMIFSKDW LVMKISANEV LRKTLEEMAK PLVYRFLGMQ SFDSQLWWSY
FSVAVIFLTQ PSLQIEQYHE TKRRKLLSTH GDMRVAMGFQ ILSMWAQLGE HKLHFIPSMV
GPFLEVTLVP EPALRKATFT VFYDMMQCEQ VSRGSFRLVE SELIDKLDLL ISENKGDDEY
RELFSTILLE RVQAENPSWR ESGTAFISSV TRLLERLLDY RSVMQGDENR DKRMTCTVNL
LNFYNDEINR KEMYVRYIYK LLDLHLGAEN YIEAGLTLKL YADMLSWDSE NISDESNGPR
EWEQKEKIYK NIISYFDKGK CWEKGIPLCK ELAMFYERKR FDYNRLSDVL IQEAKFFQNI
LTQLRPEPEY FRVGYYGTGF PSFVRNKQFI YRGLEYERIG AFIQRLQIEF PAAQILDKKH
YPPDSSVLNS PEQRFHVVNV RPISDPSHLK SAKVTVPEKI SKYYEVNDVT KFQYDRPVHK
GVVDKDNEFK SLWIERTIYD TALPLPGILR WFEVTNASIH ELTPVEFACE SVSNVNKELS
DLIVQYRLEP KRNLNPFTMR LQGSVDANVN GGFNKYQDAF FTERFAKSPE GRDQSLHVQR
LKRLIFEQMQ ILRQALELHR SLASEEVLPL HNRLSEAFLE LEKSTAEWKT NINIPTKPLP
PLPIANVQPT VVSNTSSVVQ HYFSTEDHDE TYTYLSRKTL SLSGIVPMTA MTSSPIPAPQ
VPPRDSLTSS PSAPPLPPRG HTPDKRNSNP MPFTEFVEQQ QGSAPARPRS KKYSLYEISL
NESMNHSYGS PRSSSELKGH YDLGMFNRDS GISTSSQELN NLNSGSQQMH SSAHHHHHYH
QPISTAVGGA TGSLDEYNIS LNGNGGATTP RGHQKTNSNP ESFNSINVQE MAMNSINTSL
SRITISNGAP QPPPPPIPPK SAALHHQHSF TAGSNSTPHQ FHPHHQRQQS LNLSQNSSSD
GDAISLNDIS PAPPVPFNDT FSDSFSDECD STAVGPTANN NNSHFNYDAV AYCVPKMQQQ
QQQSINTNSL GRRSLNGAAA AVDDVVEVRN TTMVPLRHDD DDEEIFY
//
