ID Q16T32_AEDAE Unreviewed; 743 AA.
AC Q16T32;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AAEL010404-PB};
GN Name=5573309 {ECO:0000313|EnsemblMetazoa:AAEL010404-PB};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL010404-PB, ECO:0000313|Proteomes:UP000008820};
RN [1] {ECO:0000313|EnsemblMetazoa:AAEL010404-PB, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL010404-PB,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AAEL010404-PB}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL010404-PB};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR RefSeq; XP_001654529.1; XM_001654479.1.
DR AlphaFoldDB; Q16T32; -.
DR STRING; 7159.Q16T32; -.
DR PaxDb; 7159-AAEL010404-PA; -.
DR EnsemblMetazoa; AAEL010404-RA; AAEL010404-PA; AAEL010404.
DR EnsemblMetazoa; AAEL010404-RB; AAEL010404-PB; AAEL010404.
DR GeneID; 5573309; -.
DR KEGG; aag:5573309; -.
DR VEuPathDB; VectorBase:AAEL010404; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_015647_0_0_1; -.
DR InParanoid; Q16T32; -.
DR OMA; NWACVAL; -.
DR OrthoDB; 231434at2759; -.
DR Proteomes; UP000008820; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR PANTHER; PTHR13018:SF153; RE44586P; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 38..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 558..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 584..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..202
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 218..372
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 383..652
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
SQ SEQUENCE 743 AA; 84028 MW; 4791C14480FB49A3 CRC64;
METNETYFPY YGPDRNSCLV LNKTKILLNL YEGIPETLLL NVIAWVFLIL LFTLLRQQAW
DYGRLALVNS HGENKRWTQL FYAHGNVGGP GGVETSDASI NMDRGFFSWI IATWRLTREQ
ILTHSGPDAI HYLSFQRHLM TVMAIITFIS ITIILPINFS GTLSGDKNSF GHTTISNLDP
NSGSMWAHVL FAIAYVPMVV LIMRRASGRN AFKTAPTRTV MVMNIAPSDC EKGVIRTYLQ
QLFPDVGIED VQMAYNISSL IKAAEEYERI ADARIYCEVH RGRDREPIQA RIKCCTCQTV
DALEYYKEEE ARLAGQVSRL RASALNEPLG IAFVTLNSAQ EAQHVILHFK PGTYRNWDLA
YAPAPSDIFW ENLNIDTAQW YFKWIAVNLV LFLFLFFLTT PVIIVNQLDT LSLTKNTTSQ
ISKISPLISE FLPTLLLWSM SALMPVIVAY SDTWLSHWTR SRQNYVIMTK TFGYLLFMIL
ILPSLGLTSA EAFLQWTIHY NETYRWECIF LPDKGAFFVN YIITAAFIGT ALELIRFPDL
ICYIWKLATS KSRAETPYIR KSILITFPFG IHYAWMVMVF TMSTVYSLAC PLIMPFAMVY
IMLKHFVDKH NLFFAFAPSN MISQGSGGKI HSTAVTMTKV SVVLLLSIMA ALAWVRSGAL
EMRALILVLA LCVTLVMFTF MSPIKKCTTK PLSIVETEGP APVYVADVLI NRRMVSDSPS
HLSYGSDTTM DIVMNDAGRS VTA
//
