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Database: UniProt
Entry: Q16UP4_AEDAE
LinkDB: Q16UP4_AEDAE
Original site: Q16UP4_AEDAE 
ID   Q16UP4_AEDAE            Unreviewed;      2080 AA.
AC   Q16UP4;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   05-JUN-2019, entry version 102.
DE   SubName: Full=AAEL009851-PA {ECO:0000313|EMBL:EAT38236.1};
DE   SubName: Full=DNA polymerase zeta catalytic subunit {ECO:0000313|VectorBase:AAEL009851-PA};
GN   ORFNames=AAEL009851 {ECO:0000313|EMBL:EAT38236.1};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT38236.1, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EMBL:EAT38236.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT38236.1};
RA   Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA   Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA   Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G.,
RA   Utterback T., Rogers Y.-H., Kravitz S., Fraser C.M.;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EAT38236.1, ECO:0000313|Proteomes:UP000008820, ECO:0000313|VectorBase:AAEL009851-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT38236.1}, and Liverpool/LVPib12
RC   {ECO:0000313|Proteomes:UP000008820,
RC   ECO:0000313|VectorBase:AAEL009851-PA};
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
RA   Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
RA   Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
RA   Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
RA   Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
RA   DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
RA   Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
RA   Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
RA   Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
RA   Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
RA   Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
RA   White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
RA   Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
RA   Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
RA   Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
RN   [3] {ECO:0000313|EMBL:EAT38236.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT38236.1};
RG   VectorBase;
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|VectorBase:AAEL009851-PA}
RP   IDENTIFICATION.
RC   STRAIN=Liverpool/LVPib12 {ECO:0000313|VectorBase:AAEL009851-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   EMBL; CH477617; EAT38236.1; -; Genomic_DNA.
DR   RefSeq; XP_001660448.1; XM_001660398.1.
DR   STRING; 7159.AAEL009851-PA; -.
DR   VectorBase; AAEL009851-RA; AAEL009851-PA; AAEL009851.
DR   eggNOG; KOG0968; Eukaryota.
DR   eggNOG; COG0417; LUCA.
DR   HOGENOM; HOG000047231; -.
DR   InParanoid; Q16UP4; -.
DR   OMA; HESHVPY; -.
DR   OrthoDB; 20210at2759; -.
DR   PhylomeDB; Q16UP4; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0016035; C:zeta DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0019985; P:translesion synthesis; IEA:InterPro.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR030559; PolZ_Rev3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   PANTHER; PTHR45812; PTHR45812; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 2.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008820};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820}.
FT   DOMAIN       52    196       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN     1215   1424       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN     1490   1939       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1991   2057       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION      402    424       Disordered. {ECO:0000256|MobiDB-lite:
FT                                Q16UP4}.
FT   REGION      485    538       Disordered. {ECO:0000256|MobiDB-lite:
FT                                Q16UP4}.
FT   REGION      646    686       Disordered. {ECO:0000256|MobiDB-lite:
FT                                Q16UP4}.
FT   REGION      703    727       Disordered. {ECO:0000256|MobiDB-lite:
FT                                Q16UP4}.
FT   REGION      741    797       Disordered. {ECO:0000256|MobiDB-lite:
FT                                Q16UP4}.
FT   REGION      849    901       Disordered. {ECO:0000256|MobiDB-lite:
FT                                Q16UP4}.
FT   COILED      371    391       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    512    529       Polar. {ECO:0000256|MobiDB-lite:Q16UP4}.
FT   COMPBIAS    646    674       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                Q16UP4}.
FT   COMPBIAS    754    770       Basic. {ECO:0000256|MobiDB-lite:Q16UP4}.
FT   COMPBIAS    774    796       Pro-rich. {ECO:0000256|MobiDB-lite:
FT                                Q16UP4}.
FT   COMPBIAS    852    867       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                Q16UP4}.
SQ   SEQUENCE   2080 AA;  235924 MW;  540D81406FCAA48D CRC64;
     MVRRGGQHVT SIRIVSVDHY MHKPEPRFDT CYSEFRGSNV KQVPVIRLFG STADGTHSCV
     HIHGVFPYLY VPFDGNTADR TAVDRLMYQI ASSLDKAINV SLGNANSAAT HVFRIALVKG
     IPIYGYHRKE HQFFKIYMYN PYLIRKANNL LMNGVILSRV FQTFESHVPY ILQFFIDYNL
     YGMSLLDVLE SAIRPRTETG EEGHLQKMST SEYEIDILAG DILNRHTLEQ EKRSEYANPG
     IASIWNDEIA RRKLLGMEQP EALSLSQSGK VEIVTESDRF FRSVLASKLT GSNNANRPVE
     GEETRLKPPV SFYPSEVADD ERLLEASCVQ DHKHFSQYSS FNMSNTVYDF DGSQVDEDRI
     VSMSQNPDAT FAEEDHQLLD IMRELEEHEN RDVENDSLLA PLTQQNERRI TSTGGSGLSL
     SQSSNKRLNA TLSGDLEMLS LMGDDKKNDD GIQVQLQDNS TLDSDDEFLL DYTMKMDPKT
     AEDLLNDSDD DILNSSVIPQ LDGADDGQLP MLRSKRTSQN RSPSGALSNG KLNGHDEPGI
     KRLKHVLVTK MSNEFEMHNV PTLTNGVHKV KPLSKPRKKI KLDQSNTTIP SETRSSVKPQ
     LFLELQRVAR FFTIDACLLR SIHLKYSPPP STVRPSANFF LVHTEPDHGG HPKRLSPRKF
     PQCRSTERQK PFPPKRKTTR YAKKSAVPNQ NNCFRCYECE SMPESPVKKP AKTPNASPLK
     ERDPSPFDVC KLAREYDLAN NYDPQEGLSR GPVRRGRSRG RGRGSRRGRP VRKQPSPEPV
     PEPEPEPDPE QQIPPQPEPE IDVILSQKFQ SIIKLSPKVL ITALSQSEVT NLQVKKADPT
     SMETIEISSE SEVIHISDEE SRSSGEQKRL SIPEISQEAA QVANRSPIST KAMTEDDEGE
     DEDLNIKSFY EHTLVFDDFD ELGSGSDGSM MELGCDNHVE DDTKVISTLQ EKPPSMADAL
     KAIQEFTIPQ VIHQEPFYSN PVDVTGRKEV GHIVLNIGGN SLNDMEEFHS VVSDMNSINN
     FRHKKLSAIY GDSLSAILGD SSRPDAGKMR ELLATEQSVI VVPAAKPPSK HEAKVWLKAM
     EKIKTEEAVP VEQDSPIKIK KMQAIMVGEG TTSTQEAQSI KIDHDSTLNL SSLITADNPV
     DSSARSTLVS KIFSMNTKSS PAMRLDHENG SPSVSSGKEH LELLSYSARR KRRKTMKARL
     SLKHSGNISA VTPNNNTYGF KVNYENLQKA KATCEYNFLT IMSVEVHIQT RGELRPNPEI
     DPISAIFYRI HNDVPEDHRR APSVCGIILN HEHGLAATDR LDPYKYNKCN YMADVVTVSN
     ERELYEKFLM LISFWDPDIF AGYEIEQASW GYIIQRGYSL EMNLMKMLSR VPTAEKVHVS
     EEEEQELLEM HEYSAGLKIP GRILLDIWRL MRHEIALTSY TFENIVFHIL HRRVSCHAFK
     QLTRLWNKPY SKWIVLEYYL ERVNGNLELL HQLDLIGRTA ELAKLFGIQF YEVLSRGSQF
     RVESMMLRIA KPRNFVSVSP SIQQRAHMRA PEYLPLILEP ESRFYADPLI VLDFQSLYPS
     MIIAYNYCFS TCLGRVEHLG QSEPFEFGAS HLRLSPRMLK VLVEKNLITI SPCGIAFVKS
     SVREGILPRM LNEILTTRLM VKGSMKLHKE NSILQRVLHS RQLGLKLIAN VTYGYTAANF
     SGRMPCVEVG DSVVSKGRET LERAIKMVET SERWGAKVVY GDTDSLFVLC PGRTKEQAFK
     IGAEIADAVT KDNPPPVKLK LEKVYQPSIL QTKKRYVGYM YETPDQEKPV YEAKGIETVR
     RDGCPVVSKM LEKVLRILFE TRDVSKVKEY TCRQFSKILE GRVNLQDFIY AKEFRGEDGY
     KPGACVPALE LTRRWKVVDP RREPRRGQRV PYVIINGPPL VPLIRLVRSP DELLADNGLK
     INSNYYIGKA IIPPLNRCLL LIGADVNQWY NDMPRKYQLL HNTGGKRSSL ASELQLPKKS
     TISQYFSTTS CIGDCGNQSH SGVCTECRKR PQRTVTYVMD KINRLERRVE LCEKMCRSCC
     QRNFETACIS LDCPVLFVLN QRTREYAQVQ YYRDLLEQMF
//
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