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Database: UniProt
Entry: Q16XB8_AEDAE
LinkDB: Q16XB8_AEDAE
Original site: Q16XB8_AEDAE 
ID   Q16XB8_AEDAE            Unreviewed;       476 AA.
AC   Q16XB8;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   16-OCT-2019, entry version 101.
DE   SubName: Full=AAEL008928-PB {ECO:0000313|EMBL:EAT39258.1};
DE   SubName: Full=Inward-rectifying potassium channel {ECO:0000313|VectorBase:AAEL008928-PB};
DE   SubName: Full=Kir2A-c {ECO:0000313|EMBL:AIN76714.1};
GN   Name=5571227 {ECO:0000313|VectorBase:AAEL008928-PB};
GN   ORFNames=AAEL008928 {ECO:0000313|EMBL:EAT39258.1};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT39258.1, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EMBL:EAT39258.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT39258.1};
RA   Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA   Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA   Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G.,
RA   Utterback T., Rogers Y.-H., Kravitz S., Fraser C.M.;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EAT39258.1, ECO:0000313|Proteomes:UP000008820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT39258.1}, and Liverpool/LVPib12
RC   {ECO:0000313|Proteomes:UP000008820};
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
RA   Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
RA   Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
RA   Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
RA   Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
RA   DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
RA   Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
RA   Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
RA   Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
RA   Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
RA   Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
RA   White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
RA   Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
RA   Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
RA   Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
RN   [3] {ECO:0000313|EMBL:EAT39258.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:EAT39258.1};
RG   VectorBase;
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AIN76714.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Liverpool {ECO:0000313|EMBL:AIN76714.1};
RC   TISSUE=Midgut {ECO:0000313|EMBL:AIN76714.1};
RX   PubMed=24657620;
RA   Rouhier M.F., Piermarini P.M.;
RT   "Identification of life-stage and tissue-specific splice variants of
RT   an inward rectifying potassium (Kir) channel in the yellow fever
RT   mosquito Aedes aegypti.";
RL   Insect Biochem. Mol. Biol. 48:91-99(2014).
RN   [5] {ECO:0000313|VectorBase:AAEL008928-PB}
RP   IDENTIFICATION.
RC   STRAIN=LVP_AGWG {ECO:0000313|VectorBase:AAEL008928-PB};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; KF686746; AIN76714.1; -; mRNA.
DR   EMBL; CH477543; EAT39258.1; -; Genomic_DNA.
DR   RefSeq; XP_001653531.1; XM_001653481.1.
DR   STRING; 7159.AAEL008928-PB; -.
DR   EnsemblMetazoa; AAEL008928-RB; AAEL008928-PB; AAEL008928.
DR   GeneID; 5571227; -.
DR   KEGG; aag:5571227; -.
DR   VectorBase; AAEL008928-RB; AAEL008928-PB; AAEL008928.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   HOGENOM; HOG000237325; -.
DR   KO; K05330; -.
DR   OMA; VFSHYAT; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008820};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     63     86       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    106    125       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    146    169       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       29    174       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      181    352       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      433    476       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    438    461       Pro-rich. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   476 AA;  54690 MW;  64FB7D65181600C4 CRC64;
     MAVGSLRRNE SSRAFRPGTT RKYRKRAILK SGECNISTSK VSQQHLRFLQ DIFTTLVDAQ
     WRWTLLVFAF SFIGSWLFFA VIWWLIAFTH GDLEEMHLPD HQAEVGWTPC VYNIVSFTSC
     FLFSIETQHT IGYGVRTTTE ECPEAIFIMC FQSIYGVMIQ AFMVGIVFAK MTRPKHRTQT
     LLFSKNAVIC QRDGELSLMF RVGDMRKSHI IGASIRAQLI RTRTTKEGEI LSQYQTELDV
     GADGCGSDLF FIWPQIVVHK INENSPMYNM CASDLLQDRF EIVVILEGTV ESTGQSTQAR
     SSYVNSEILW GHRFEPVVFY NKDNQGYEIN YSKFDETQQV DTPLCSAREL AEFYKIQDDY
     RSNDNLDNIS SKTLLEKRWQ RKYETLMHSI SQFHLEDESG SMRLSPLPTY LTIQNIPRRN
     RSYLQLENNL RNLFDSPLTH PPPTPQDGPP SSTPPPAINE PPGYVAGQRA RSRTNS
//
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