ID Q16Y69_AEDAE Unreviewed; 1472 AA.
AC Q16Y69;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=AAEL008647-PA {ECO:0000313|EMBL:EAT39570.1};
GN ORFNames=AAEL008647 {ECO:0000313|EMBL:EAT39570.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT39570.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT39570.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT39570.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT39570.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT39570.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT39570.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT39570.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CH477523; EAT39570.1; -; Genomic_DNA.
DR RefSeq; XP_001659384.1; XM_001659334.1.
DR STRING; 7159.Q16Y69; -.
DR PaxDb; 7159-AAEL008647-PA; -.
DR VEuPathDB; VectorBase:AAEL008647; -.
DR eggNOG; ENOG502QVZW; Eukaryota.
DR OMA; YPAGDRY; -.
DR PhylomeDB; Q16Y69; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01099; PAN_AP_HGF; 4.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 4.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR001507; ZP_dom.
DR PANTHER; PTHR47327:SF13; APPLE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47327; FI18240P1-RELATED; 1.
DR Pfam; PF00024; PAN_1; 4.
DR SMART; SM00473; PAN_AP; 4.
DR SMART; SM00241; ZP; 1.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 4.
DR PROSITE; PS50948; PAN; 5.
DR PROSITE; PS51034; ZP_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1472
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004185284"
FT TRANSMEM 1335..1360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..141
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 151..235
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 242..326
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 350..429
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 875..966
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 980..1222
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT REGION 434..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1212..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1272..1292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1393..1413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1443..1472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..590
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..659
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1472 AA; 166551 MW; C1C4CB20E4A503C3 CRC64;
MRKRQKLLPG MSDIAVIVIL ARLVLVLGQT TCNNGQGRVL YERLPNQQLQ GFDDDVVRDS
APPFRVLEKC QDLCLRDRTA SNNLGRACTS FDFQPGSRIA SFSGSAEYEE STCYLTREQA
APEGIGNLML VPNSVHFTEV CLSSSRPDRE CPSRRYVFER HPRKKLKLPV SDIKEVTAAN
RSDCEDKCLN EFSFVCRSAN YDSTLRSCSM SRFTRRTHPE LLEDDPNSDY LENTCLNAER
RCDGLVVYVK EENKRLGGPF EVEIFNNMTL EECQSLCLRA EKYFCRSIEF DDQTKQCILS
EEDSVSQKDD LSISSSPTHH FYDLVCLDNQ RGTDYPENSV TSHLFASGRR PDTAFQRYRN
SRLGGEFHSE ITGRSLSECL DECLRQTSFQ CRSAVYSDRF RTCRLSRYNQ RDGMRIIYDA
DYDYYENLMP HLVGGDSDST NGRPDPTDWR PPYGDRDRDR IPDDRAPGRF PPGERYPPGL
RPDYGGNRAD HVEHLAFVTL TSKTFPGGYP STDRYPGPTD RYPMGPGTDR YPADFDGRYP
PVYDNRFPGD RYGPTDRYPD REPDLYPGIP PMRYPPPDSR YPPDTRYPPT PDTRYPTDSR
YPPDSRYPVD NRYPKDPRYP TDPRYPTDSR YPPPTPDSRY PPMRPETRYP LAPTGTRYPP
PYMPQMYPNY QSGYPPPPRT PPDRGFTTDR YPPPLRPVDN NRYPAPDSRY PMEPIPAQGR
YPTSQHQIPL LPHKYNDGNQ MFHFSYDNPC YMLCVAIHQY KCENLEHPGT YGNSLPTLQQ
ILPYDRYDPY ERGYGDNRGY GPYYPPSGVG RIPPPMPLPA FPDRDRGYRR PGMPDGGGYP
FEIPYGPSSS GYDNTLGGGD GFGGFGPQRP YETRCDGYDS FKQMASKRKM RKQFIRRVIN
APSLGVCQQE CVAARDFMCR SFNYRESAPY ETEGNCELSD RDSRDLDIPS SQMFETDNSD
YYERSMGRGQ GDECLDVGQL CNEDGMEFTL KTPEGFVGRI YAYGFYDRCF FRGNGGTVNV
LRISGPGGYP ECGTQRYGDT MTNIIVVQFS DNVQTGRDKR FNLTCMFRGP GEAVVTSGYI
GAGSGSPIPI EYLPAENSMS NKVRLMILYQ GRPTTTIAVG DPLTFRLESQ DGYSHATDIF
ATNVVARDPY SGRSVQLIDN YGCPVDNLVF PELGRSRDND ALEARFNAFK IPESNFLVFE
ATVRTCRGGC QPAYCPGPSG RSEPSFGRRR RSVSENPTDF DGTAEPLTSS NTDDDDDEVS
IVNGTVIRDT KVLKNGTKDG EDSTGDDLEA NASEMPEQVR EMIEVFQSRE EMQQDTVARK
MVAPQETVCL THSEYYGLLS ALILLMILLI SITFASGLAY RRYWKVFMKN RALDRTSPVN
SFTPSALHNV SGSQFHASGR GTSSSRGEGN IRSPGLSLFG NGLQKTFATG NLSRMCQIPV
MNPISRTNGN KSEFDDPSEP IYTDPSLFER SR
//
