ID Q16YC4_AEDAE Unreviewed; 1082 AA.
AC Q16YC4;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=AAEL008591-PA {ECO:0000313|EMBL:EAT39602.1};
GN ORFNames=AAEL008591 {ECO:0000313|EMBL:EAT39602.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT39602.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT39602.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT39602.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT39602.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT39602.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT39602.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT39602.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CH477519; EAT39602.1; -; Genomic_DNA.
DR RefSeq; XP_001653323.1; XM_001653273.1.
DR AlphaFoldDB; Q16YC4; -.
DR STRING; 7159.Q16YC4; -.
DR PaxDb; 7159-AAEL008591-PA; -.
DR VEuPathDB; VectorBase:AAEL008591; -.
DR eggNOG; KOG4441; Eukaryota.
DR HOGENOM; CLU_004193_2_0_1; -.
DR OMA; CMENIGD; -.
DR PhylomeDB; Q16YC4; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR CDD; cd18445; BACK_KLHL2_like; 1.
DR CDD; cd18235; BTB_POZ_KLHL2-like; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF475; RING CANAL KELCH PROTEIN; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 96..162
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 51..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 865..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..733
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..893
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..1000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1019..1035
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1043..1064
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1082 AA; 119045 MW; A5F6EF39C701A90C CRC64;
MISFIQYTLN IMSNLSNSHN SNTGSSQNSA AEGTMERGSC ILVRYASQNS LDESSQKQLP
RSNGKDKTVG GAYRNNVHTQ RSFEAMNNMR EQNLLCDVIL VADGMEIPAH KMVLASCSPY
FYAMFTGFEE SRQDRITLQG VDHRALQLLI EYVYTSVVEV TEDNVQVLLT AANLLQLTDV
RDACCDYLQT QLDPSNCLGI RDFADIHGCI DLLNYAETYI EQHFSEVVQF DEFLNLTSEQ
VVNLIKSDRL SVPSEEKVYE CVISWLQYDI CTRQSFLADL MEHVRLPLLS QEYLVQRVEK
EQLLKGDLQC KDFIIEALKY HLLKGELKTT FKTPRTIPRQ PVGLPKVLLV IGGQAPKAIR
SVECYDLREE RWYQVAEMPT RRCRAGLAVL GDRVYAIGGF NGSLRVRTVD VYDPVQDQWS
TCNSMEARRS TLGVAVLNGC IFAVGGFDGS SGLSSAEMFD PRTQEWRLIA SMSTRRSSVG
VGVVNGLLYA VGGYDGASRQ CLASVERYNP ALDTWTQVSE MTDRRSGAGV GVLDNILYAV
GGHDGPLVRK SVEAYNAETN TWHKVADMAF CRRNAGVVAH KGMLFVVGGD DGTSNLASVE
VYTPETNTWR LLPASMSIGR SYAGVAMIDK PIQNNNQNND DENSQAEGLN SEAGAVGYNQ
ASNNNNNNNV NNNNNVHYEN IYESIEQYAA AANAGVAAVA PAVAQNPSGI IPQGNPLLGM
PSNQPPQPGP GPSSLSMGPR SNNVQPGVVP GPPPPPSMLQ MQQQYLSLAY RNELYDRTAG
YDVPRGGGVP RNNYYQNQQS MATGPRYQNL HLDLNRPRYS HNSMRAPRQR SFDDTESYQY
HRYQNQNFAK FDNVYERVRE EPAYQNTGYV NRARSESPAR SGTNRREERN GGDPFRNWAF
NFEDNSFRPA SSVPRPREIR RITDGTFRAT DYQQDNERLG LSREAPKTPP TIVVNASASP
STSRSNSASP PKSKESSVSP VQPERGGTPA SSSSDSEIFV MDSVASDAGG PAEDSSACGG
AGASSSMQCM ENIGDMGDTN ATKDKEGASS QETSESSNFE DNAAESSGSD DDVVDEKNVD
IT
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