GenomeNet

Database: UniProt
Entry: Q16YE7
LinkDB: Q16YE7
Original site: Q16YE7 
ID   CUE_AEDAE               Reviewed;         664 AA.
AC   Q16YE7;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   16-JAN-2019, entry version 77.
DE   RecName: Full=Protein cueball {ECO:0000250|UniProtKB:Q95RU0};
DE   Flags: Precursor;
GN   Name=cue {ECO:0000250|UniProtKB:Q95RU0}; ORFNames=AAEL008564;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1] {ECO:0000312|EMBL:EAT39657.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
RA   Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
RA   Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
RA   Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
RA   Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
RA   DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
RA   Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
RA   Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
RA   Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
RA   Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
RA   Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
RA   White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
RA   Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
RA   Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
RA   Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Has a role in spermatogenesis and oogenesis.
CC       {ECO:0000250|UniProtKB:Q95RU0}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass
CC       type I membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cueball family. {ECO:0000305}.
DR   EMBL; CH477517; EAT39657.1; -; Genomic_DNA.
DR   RefSeq; XP_001653297.1; XM_001653247.1.
DR   ProteinModelPortal; Q16YE7; -.
DR   STRING; 7159.AAEL008564-PA; -.
DR   EnsemblMetazoa; AAEL008564-RA; AAEL008564-PA; AAEL008564.
DR   GeneID; 5570793; -.
DR   KEGG; aag:5570793; -.
DR   VectorBase; AAEL008564-RA; AAEL008564-PA; AAEL008564.
DR   eggNOG; KOG1215; Eukaryota.
DR   eggNOG; ENOG410XP34; LUCA.
DR   HOGENOM; HOG000045594; -.
DR   InParanoid; Q16YE7; -.
DR   OMA; ETPCFDP; -.
DR   OrthoDB; 520442at2759; -.
DR   PhylomeDB; Q16YE7; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 2.120.10.30; -; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   SMART; SM00181; EGF; 4.
DR   SMART; SM00135; LY; 5.
DR   PROSITE; PS00022; EGF_1; 5.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 3.
PE   3: Inferred from homology;
KW   Cell membrane; Complete proteome; Differentiation; Disulfide bond;
KW   EGF-like domain; Glycoprotein; Membrane; Oogenesis;
KW   Reference proteome; Repeat; Signal; Spermatogenesis; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     21       {ECO:0000255}.
FT   CHAIN        22    664       Protein cueball. {ECO:0000255}.
FT                                /FTId=PRO_0000386566.
FT   TOPO_DOM     22    552       Extracellular. {ECO:0000255}.
FT   TRANSMEM    553    573       Helical. {ECO:0000255}.
FT   TOPO_DOM    574    664       Cytoplasmic. {ECO:0000255}.
FT   REPEAT      115    157       LDL-receptor class B 1. {ECO:0000255}.
FT   REPEAT      168    211       LDL-receptor class B 2. {ECO:0000255}.
FT   REPEAT      212    257       LDL-receptor class B 3. {ECO:0000255}.
FT   DOMAIN      367    399       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      402    438       EGF-like 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      473    510       EGF-like 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   CARBOHYD     40     40       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    140    140       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    188    188       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    431    431       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    491    491       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    551    551       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    371    380       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    375    390       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    406    416       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    410    426       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    428    437       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    477    487       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    481    498       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    500    509       {ECO:0000255|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   664 AA;  75077 MW;  F0169CE54C27EB20 CRC64;
     MRNLGIAVTF AVLLVIGYVT ALEWDAVVTT DSGILFFDKN WTQISSGGHQ FHHISAFAYD
     EVKRKLYFSD LKDPSFRIFS LDTKPEEEYH KVAKLLPKSD QTGYITGLAF DHLERKLYWT
     EKGTHSVYSV EVDKLGAPAN ATDGLINLVA QVEENHDLAA LTIDECRRHL YWTNSYLQTS
     SIVRAAMNGT VLDDHKEDVY EPRGISVDHY NNRIYWVEKK YGRAFTVESA NLEVQDRQTF
     LRGEDKIPTH VSPNSQYLYW IDQEDGEVHE TMKSDSKVTR VVYKGSRPSA LIIRSGLLVE
     YQKNNPSCKA VVSEIIDNVR KESSEVKDVA QAVTSKPEMI TCLNKGILNH NTNSCICLPE
     YQGTFCEIPI CNNFCVHGEC VVGADSRPMC KCHAEFEGER CDRNICDGYC LNNGRCALSA
     TGQRSCTCSK NFSGARCETA ICTSDYCYNG ECFVENEVPE CKCNVGYRGD RCEEYTCNNY
     CLHDGTCILN NDTMLVECRC GSEYTGKRCE IPKRFCSLDN GNPEMQQYCE GVAIAKNLVE
     PQVTYCKNSF NRTVVYVSLA FTASLVTLVT ILCTVRRMYE RNRPRITKRF KVTNNTQMTS
     RPATQCEITI ENCCNMNVCE TPCFDTKILQ KSATKAEDKQ FLLDDIESIA GSYRKLPSCV
     AEKN
//
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