ID Q17792_CAEEL Unreviewed; 327 AA.
AC Q17792;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 3.
DT 27-MAR-2024, entry version 156.
DE SubName: Full=Homeobox domain-containing protein {ECO:0000313|EMBL:CAA90100.3};
GN Name=ceh-58 {ECO:0000313|EMBL:CAA90100.3,
GN ECO:0000313|WormBase:C07E3.6};
GN ORFNames=C07E3.6 {ECO:0000313|WormBase:C07E3.6}, CELE_C07E3.6
GN {ECO:0000313|EMBL:CAA90100.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA90100.3, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAA90100.3, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA90100.3,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR EMBL; BX284602; CAA90100.3; -; Genomic_DNA.
DR PIR; T19056; T19056.
DR RefSeq; NP_496234.3; NM_063833.5.
DR AlphaFoldDB; Q17792; -.
DR SMR; Q17792; -.
DR IntAct; Q17792; 2.
DR STRING; 6239.C07E3.6.1; -.
DR EPD; Q17792; -.
DR PaxDb; 6239-C07E3-6; -.
DR PeptideAtlas; Q17792; -.
DR EnsemblMetazoa; C07E3.6.1; C07E3.6.1; WBGene00007417.
DR GeneID; 182371; -.
DR KEGG; cel:CELE_C07E3.6; -.
DR UCSC; C07E3.6; c. elegans.
DR AGR; WB:WBGene00007417; -.
DR WormBase; C07E3.6; CE35825; WBGene00007417; ceh-58.
DR eggNOG; ENOG502TGJJ; Eukaryota.
DR HOGENOM; CLU_676588_0_0_1; -.
DR InParanoid; Q17792; -.
DR OMA; KRETMCK; -.
DR OrthoDB; 454859at2759; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00007417; Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR PANTHER; PTHR24324:SF5; HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX; 1.
DR PANTHER; PTHR24324; HOMEOBOX PROTEIN HHEX; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Proteomics identification {ECO:0007829|EPD:Q17792,
KW ECO:0007829|PeptideAtlas:Q17792};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 247..309
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 249..310
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 53..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 327 AA; 36201 MW; EC9DCD4497AFE7E9 CRC64;
MSAFQGNMFV LVNVDQHRDL IGPIINQLVA DYGTPVSIVD NIQKICPKCS CTPHANPDSS
SVPTTTSSDE HQEEPPTPKT IAPAPIATPV LKPLLPQRES IVSNGIHPVV VKRKQSIAEE
IDTPEIKKSR VVEPVKVKTE TIILDDDDGN VLDTVLAALQ NGNHEMQFTG SGGSSDDGAS
NSSNIYDVDD EDYGTSQWNP DFLTNFITSQ PNIFSVTGQN IKSSPSKNAG QTPNGKRQVP
PMLTVNGKTR RGRIVYSTQE LNILEKYYEE DPNACADPRK RETMCKTLSI DYHRLKVWFQ
NRRRKDKVRS QEEAATTFNG LDYSEDS
//
