ID Q17A99_AEDAE Unreviewed; 872 AA.
AC Q17A99;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 24-JAN-2024, entry version 110.
DE RecName: Full=AP-1 complex subunit gamma {ECO:0000256|PIRNR:PIRNR037094};
GN ORFNames=AAEL005364 {ECO:0000313|EMBL:EAT43192.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT43192.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT43192.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT43192.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT43192.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT43192.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT43192.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT43192.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000256|PIRNR:PIRNR037094}.
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DR EMBL; CH477337; EAT43192.1; -; Genomic_DNA.
DR RefSeq; XP_001650783.1; XM_001650733.1.
DR AlphaFoldDB; Q17A99; -.
DR STRING; 7159.Q17A99; -.
DR PaxDb; 7159-AAEL005364-PA; -.
DR VEuPathDB; VectorBase:AAEL005364; -.
DR eggNOG; KOG1062; Eukaryota.
DR HOGENOM; CLU_003824_0_0_1; -.
DR OMA; REPNTKK; -.
DR PhylomeDB; Q17A99; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0030121; C:AP-1 adaptor complex; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 2.60.40.1230; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR017107; AP1_complex_gsu.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008153; GAE_dom.
DR PANTHER; PTHR22780; ADAPTIN, ALPHA/GAMMA/EPSILON; 1.
DR PANTHER; PTHR22780:SF5; AP-1 COMPLEX SUBUNIT GAMMA; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR PIRSF; PIRSF037094; AP1_complex_gamma; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR PROSITE; PS50180; GAE; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR037094};
KW Golgi apparatus {ECO:0000256|PIRNR:PIRNR037094};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037094};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR037094};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037094}.
FT DOMAIN 754..867
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 653..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 872 AA; 97415 MW; 4E47F00994D5F203 CRC64;
MGFFLFREFR EIAEVNQKRI FPEDSDTTTD YTAITLVVFL FTTLYTERSA LLNSRNGTSL
RKPSPTRLRE LIRQIRAART AAEERAVVNT ECAYIRSTFR ETDCIWKCRN MAKLLYIHML
GYPAHFGQME TLKLAASSKF TDKRIGYLGA MLLLDERQDV HVLLTNCLKN DLNNSTQFIV
GTALCTLAAI ASPEMARDLS HEIERLIASS NAFLRKKAIL CAFRMVRRVP ELMEEYIPKC
SHFLNDKNHG ILISTITLVT EMCEQSPVVL NYFKSSIPTL VRTLKTLIVS GYSPEHVVNG
VSDPFLQVKI LRLLRILGHG DTAQSEIMND VLAQVATNTE TNKNAGNAIL YETVLTIMNV
ESENSLRVLA VNILGRFLLN SDKNIRFVGL LTLVRTVQRD MTAVQRHRIT ILECLTDSDS
SIQKCAMELS FTLVNSQNIE TIVRELLKYL ETAEAEMKGT CSSRIVLAAE MYSPSIHWHL
DVLLKVLTIS GNNIRDDVIA STIQLISNSP PKEQSYISGK MWKSITNMNQ LENRQPLVQV
AVWTLGEYGE SGSFDENELI DHYRQLLWAP QLSITTKQYI LVSLAKISVR MEHCTANIQN
IINAFRVHLN IDLQQRAVEF HQLFTSHNHL RAALLEKMPV LKISELTTSE YNSDFAGSAE
PTSASSPSEE STPQKQVSNQ DILLDLLGDS FGSGSSTSNT TTTPSPLQQS TPNEPPPATN
TILDLLGLGG MDQSGSFTAT VSPLPSGFGS PTEYSATTIL VYSQDNIDIR FIVKKEGDHA
VVTAKTTNNS LNMLEKFMLQ VAVPKAFTIQ MMVPSSTVML PGESVVQDIN VIRTNPAASS
PLRMKVRFSY DIGNYSVMEQ ADVNDFPPDL FI
//
