ID Q17BJ8_AEDAE Unreviewed; 1582 AA.
AC Q17BJ8;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=AAEL004968-PA {ECO:0000313|EMBL:EAT43612.1};
DE Flags: Fragment;
GN ORFNames=AAEL004968 {ECO:0000313|EMBL:EAT43612.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT43612.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT43612.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT43612.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT43612.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT43612.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT43612.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT43612.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CH477321; EAT43612.1; -; Genomic_DNA.
DR RefSeq; XP_001650080.1; XM_001650030.1.
DR PaxDb; 7159-AAEL018040-PA; -.
DR VEuPathDB; VectorBase:AAEL018040; -.
DR eggNOG; KOG0059; Eukaryota.
DR OMA; TYIVREH; -.
DR PhylomeDB; Q17BJ8; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF185; ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 402..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 809..830
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 978..1000
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1021..1052
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1058..1079
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1091..1111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1174..1192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 447..676
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1239..1458
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 198..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1582
FT /evidence="ECO:0000313|EMBL:EAT43612.1"
SQ SEQUENCE 1582 AA; 180568 MW; E7818322BF29B19D CRC64;
TDDIVKFANQ TFVDMARLRD FFKALNTTVQ LLHTDDSFRG SFENLIELAK SPLVQMIVGG
NVNIELIEGM LNGILNDRTV AVTLETIASI FECFSADRFI KVESEKQLED EAFKLNQKKM
FFAGLIFENG TTENEVAYKI RMRIDDTPVT VENKNRFWFP DPEASFELDM RYHRGFIQIQ
HAVDMGIIKA LKKEKAESGK ERSSAASTSD EGLSLDDELG DEENETEGTT ATTTAGKSLY
LNLSQKINIS QSDLDKFSNK SSLDDYLDFN DDEANEEVDE EEPLVMDTAT IRSRRKRAPQ
FNLFSLFLGG GSPQKEEMTY NVDGEKFYTK QFPYPKFIKD HGNTMVIQLY ENRIHHLFKN
FPLSLSFSTA FCYAWRYIMR LELQQRSADF MALKGSIQEN DLAFGILMML LDAVIYYLIG
LIYERLTHED TTFYQVNRCK LDKSIGAELR NVDVIYENDK KVLDNVSITF KRDEVTCLLG
RNGAGKSTII KLLTGQVLPV VGDVTLPLDY DIISGLKNNA EKIGLCSQND ILIPNLTAKE
HLQLYARIKL TKGFETEVQR TLDNLKMGKY KHYRASELSG GFKRRLCIAI AFLGSPNLVI
LDEPCSSVDT KARKYIWELI QTLRKDRAVI LATHHLDEAE SLSDKVVVME NGKAILEQSH
EELKNRFTNT LYLELMLKTM TESDRSNLIS DLNKSLDERT NVQYELAKLP RNKLQYKLTY
TSADPSENEY LNQYQNKKLI LSYDLKNENL MNIFNAVNSR ESQSADIREP EIVSANGFHG
SKPTEHKLSS FQIICSLLHK RFLHFRRNFR LLICLLVLPT LFEIIAMYFM TIRPPGEHDQ
AIELSTALYR DSAEFYTRTG NGSEFQREID TGILSHCPDA DCYLFKNSEE AHRWILQTNY
EFADRRFGGL TARKEKHFVW YNNKGYHSMP VWLNLLDSAI LKAELENSSY SIRTINHPLK
IEEDELTISS ILQQVSDAGI SLILLLSFSL VLAGASVYIV NERVRGEKMQ QRLAGVKFCH
YWGVTYLWDA MIFLIAVALA VIVFQVFAIP AYVEKDQLSG ICLLLVFYGF ASIPAVHLFE
KLFNDASFAN MSLFCLNVIT ALGTLTIIIL FDILGESETS EHFRNFLNRA FLILPQHALA
DGLIELSKNY IQAEIFKRYY INTYKPLMTI LEPHLIALAI MGVIFTLLNV IIERKVIQRF
FQEAESSHTP VYELKTVRSE EAIMNGNGKK KSLTADQILS VDHLTKQYRS GDVVVNDVSF
KIHYGECFGL LGTNGAGKST IFSILAGEQL PSSGGFCFFS SNCLSYCPQN SFLDPLLTVE
EVIEFYGQLR NVDSIDKLVI ETLREYHLEP YKRILVKNLS GGNRRKLCVA VACFGNTDII
LMDEPTSDMD PVTRAIVYRT IERLNSQNRS VLLTSHSISE IDRICQRIAI LKDGYLLTVD
SPDKLTERYG NNYLVTIYLE DNREVDLIRT IKREFNVSED LIQNKNSLQF VCKVQPDSRR
HNNGGIEKLH KNSQVTINLN NNTIDSSPAV MESVSALVVK LHQFAENNRL RYTVSRCLLD
QVFENVLQNH EEEHSNDGFV EN
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