GenomeNet

Database: UniProt
Entry: Q17DT0
LinkDB: Q17DT0
Original site: Q17DT0 
ID   UBA5_AEDAE              Reviewed;         397 AA.
AC   Q17DT0;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   16-JAN-2019, entry version 76.
DE   RecName: Full=Ubiquitin-like modifier-activating enzyme 5;
DE            Short=Ubiquitin-activating enzyme 5;
GN   ORFNames=AAEL004076;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
RA   Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
RA   Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
RA   Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
RA   Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
RA   DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
RA   Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
RA   Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
RA   Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
RA   Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
RA   Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
RA   White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
RA   Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
RA   Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
RA   Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: E1-like enzyme which activates UFM1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA5
CC       subfamily. {ECO:0000305}.
DR   EMBL; CH477291; EAT44584.1; -; Genomic_DNA.
DR   RefSeq; XP_001648375.1; XM_001648325.1.
DR   ProteinModelPortal; Q17DT0; -.
DR   SMR; Q17DT0; -.
DR   STRING; 7159.AAEL004076-PA; -.
DR   EnsemblMetazoa; AAEL004076-RA; AAEL004076-PA; AAEL004076.
DR   EnsemblMetazoa; AAEL004076-RB; AAEL004076-PB; AAEL004076.
DR   eggNOG; KOG2336; Eukaryota.
DR   eggNOG; COG0476; LUCA.
DR   HOGENOM; HOG000256352; -.
DR   InParanoid; Q17DT0; -.
DR   OMA; ETHNYNI; -.
DR   OrthoDB; 1092362at2759; -.
DR   PhylomeDB; Q17DT0; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; SSF69572; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Ubl conjugation pathway; Zinc.
FT   CHAIN         1    397       Ubiquitin-like modifier-activating enzyme
FT                                5.
FT                                /FTId=PRO_0000391938.
FT   ACT_SITE    243    243       Glycyl thioester intermediate.
FT                                {ECO:0000250}.
FT   METAL       219    219       Zinc. {ECO:0000250}.
FT   METAL       222    222       Zinc. {ECO:0000250}.
FT   METAL       296    296       Zinc. {ECO:0000250}.
FT   METAL       301    301       Zinc. {ECO:0000250}.
FT   BINDING      76     76       ATP; via amide nitrogen. {ECO:0000250}.
FT   BINDING      97     97       ATP. {ECO:0000250}.
FT   BINDING     120    120       ATP. {ECO:0000250}.
FT   BINDING     143    143       ATP. {ECO:0000250}.
FT   BINDING     177    177       ATP. {ECO:0000250}.
SQ   SEQUENCE   397 AA;  43423 MW;  CDFE75D56B78B9BD CRC64;
     MATMEELKLQ IETLQSELCK LKATSAGGAR EKIEKMSSEV VDSNPYSRLM ALQRMGIVSE
     YERIRQKSVA VVGVGGVGSV TADMLTRCGI GKLILFDYDK VELANMNRLF FTPDQAGLSK
     VEAAAKTLNF INPDVKILTN NYNITTVESF DKFLNAIKTG GIEEGTPVDL VLSCVDNFEA
     RMAINTACNE LSLNWFESGV SENAVSGHIQ FIRPGDTACF ACAPPLVVAE NIDEKTLKRE
     GVCAASLPTT MGIVAGMLVQ NTLKYLLNFG TVSDYLGYNA LIDFFPKMSL KPNPTCDDRF
     CIDRQKDYAA RPKEERVEEV PEEETPLHEE NLYGIELVAE DDTQGSQPST GTTHSISTGL
     KLAYEPPAST KHSETTSTTA VSDDVSLDEL MAQMKSM
//
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